Novel fluoro-silicone coating preventing pollution flashover is disclosed. The coating includes, by weight, 10-80 parts of a fluorinated acrylate monomer, 9-60 parts of an acrylate monomer, 7-43 partsof a silane coupling agent, 2-23 parts of polysiloxane, 0.2-1.8 parts of an initiator and 1-80 parts of a solvent. The coating has excellent hydrophobicity, hydrophobic mobility, weather fastness, chemical resistance, ageing resistance, self-cleaning performance, electric performance, tear strength, shearing strength, and flame retardant performance, and is suitable for an electrical power system. A preparing method disclosed is high in manufacturability, and material and object surfaces can be coated with the coating prepared by the method in dip-coating, spread-coating and spraying mannersand the like. The coating prepared is easy to dry, easy to shape, easy to clean and capable of repeated coating, and the drying time at room temperature is not longer than 10 min. The coating has advantages of simple construction process and easy operation and is safe and environmentally friendly.