38results about How to "Bioadhesive" patented technology

The invention discloses an acidic buffering sterilization gel for vagina gynaecologically. The gel consists of the following substances in parts by weight: 0.2-0.5 part of bactericide, 12-12.5 parts of glycerol, 83-84 parts of water, 1-1.5 parts of Carbomer, 1.5-2 parts of polycarbophil, 0.2-0.3 part of triethanolamine, 0.01-0.03 part of vitamin E, and 0.01-0.03 part of mint. The acidic bufferingsterilization gel has the advantages that: pathogenic bacteria can be quickly and effectively killed, inflammatory symptoms can be quickly and effectively relieved, normal pH value of the vagina is maintained, elasticity of the inner wall in the vagina can be kept, wetness of the vagina is maintained, and drug tolerance and drug resistance do not generate.

The invention discloses a thermosensitive in-situ gel preparation for norcantharidin injection and a preparation method and an application of the thermosensitive in-situ gel preparation. The thermosensitive in-situ gel preparation is prepared from a solvent and solute, wherein the solute is prepared from the following components by weight-to-volume ratio: 0.0025g / mL of norcantharidin, 0.19g / mL of poloxamer 407, 0.004g / mL of poloxamer 188, 0.0057g / mL of polypropylene, 0.0019g / mL of polyethylene glycol, 0.0008g / mL of hydroxypropyl methyl cellulose and 0.0002g / mL of chitosan. The gel temperature of the in-situ gel preparation is 34 DEG C, is close to the body temperature of a human body, and accords with the requirements of in vivo gel for injection; gel corrosion and drug release are carried out at a similar velocity; the drug is controlled to be slowly released by gel corrosion; the thermosensitive in-situ gel preparation has good drug slow-release and sustained-release effects; and the medication safety is good.

The invention discloses a superporous hydrogel composite, its preparation method and its application in pharmacy. The superporous hydrogel composite of the present invention contains a crosslinked polymer and carbomer, and has a superporous structure. The polymer is formed by polymerization of at least one unsaturated ethylenic monomer and a polyene crosslinking agent. The superporous hydrogel composite of the present invention is prepared by the following steps: mixing at least one unsaturated ethylenic monomer, a polyene crosslinking agent, carbomer and a foaming agent; Formation of superporous hydrogel composites under the condition of bubbles. The superporous hydrogel complex of the present invention can be used in gastric floating preparations and protein polypeptide oral drug delivery systems. Compared with the prior art, it has bioadhesive properties and protease inhibition.

The invention discloses an iron-based biochar material as well as preparation and application thereof. In the invention, by adopting nano alpha-Fe2O3 as a center substance and wrapping the nano alpha-Fe2O3 with aspergillus niger hyphe, the iron-based biochar material for arsenic-polluted soil remediation is prepared through anoxic high-temperature carbonization. The synthesized iron-based biochar material is uniformly mixed with soil according to certain proportion; and after a period of time, the fixed rate of the water-soluble state arsenic and effective-state arsenic in the arsenic-polluted soil reaches 59.6% and 66.2% respectively. The iron-based biochar material disclosed by the invention has the advantages of easiness in preparation, high efficiency without toxicity, biodegradability and no secondary pollution or damage of physicochemical properties of soil and is an environment-friendly fixing agent.

The invention discloses a composite denitrification biological tank which comprises a biological tank body, and the biological tank body is composed of a water distribution system, a gas backwashing system, a biological filler, a filler support, a backwashing wastewater drainage channel, a backwashing wastewater drainage pipe and a carbon source accurate adding control system. The water distribution system comprises a water inlet pipe, water distribution pipes, a water outlet pipe and a water outlet channel, the water inlet pipe communicated with the biological tank body is installed on one end face of the bottom of the biological tank body, the water distribution pipes are evenly arranged on the water inlet pipe located in the biological tank body at equal intervals, and a water outlet channel is arranged on the upper portion of the biological tank body. The water outlet pipe is mounted at the side end of the upper part of the biological tank body, is distributed away from one side of the water inlet pipe and can realize fluid communication with the water outlet channel; and the air backwashing system comprises a backwashing air pipe and an air inlet control valve, and the backwashing air pipe is mounted on one side, deviating from the water inlet pipe, of the biological tank body. Thecomposite denitrification biological tank has the advantages of high efficiency, stability, simplicity in management, low cost and low energy consumption.

The invention discloses calcium alginate composite microspheres for stabilizing water-in-oil type Pickering emulsions and a preparation method thereof, belonging to the technical field of material polymers. Alkylsilane-grafted inorganic nanoparticles are coated on the surface of calcium alginate microspheres to form calcium alginate composite microspheres. The particle size distribution of the microspheres is 2-8 μm; it has a core-shell structure, the core is hollow, and the shell has two layers. The total thickness of the two-layer shell is 1~1.5µm, calcium alginate is the inner shell, and inorganic nanoparticles are assembled to form the outermost shell; it overcomes the fact that chitosan coated on the surface of calcium alginate microspheres can only stabilize the oil-in-water type Pickering emulsion, as a drug carrier, can only encapsulate oil-soluble drugs but not water-soluble drugs. The use of improved emulsion polymerization to prepare calcium alginate composite microspheres also has the biocompatibility of calcium alginate, Adhesion and encapsulation of protein macromolecules can stabilize the water-in-oil Pickering emulsion very well. It can widely expand the application of Pickering emulsion as a drug carrier in the fields of biomedicine, cosmetics industry, food industry and enzyme engineering.

The invention discloses a micro-occluder for cerebral aneurysm, which comprises a main body of the occluder, a filling liquid, a delivery tube, and a push catheter. A limit block is connected, and the liquid outlet end of the check valve is provided with a blocking body, the blocking body is made of biogel material with elastic deformation properties, and the filling liquid passes through the push conduit and the check valve Enter the bluff body. The parts of the invention have less dependence on the process size, and are especially suitable for small cerebral aneurysms. The filling fluid enters the blocking body through the push catheter and the check valve, so that the biogel material with elastic deformation performance can be used during the filling of the filling fluid. Elastic deformation occurs under the action, so as to expand and expand, and play the role of blocking cerebral aneurysms. The material of the blocking fluid is biogel material, which has bioadhesiveness and can successfully adhere to cerebral aneurysms, thereby Increase the strength of brain aneurysms and reduce the risk of brain aneurysm rupture.

The invention discloses a thermosensitive in-situ gel preparation for norcantharidin injection and a preparation method and an application of the thermosensitive in-situ gel preparation. The thermosensitive in-situ gel preparation is prepared from a solvent and solute, wherein the solute is prepared from the following components by weight-to-volume ratio: 0.0025g / mL of norcantharidin, 0.19g / mL of poloxamer 407, 0.004g / mL of poloxamer 188, 0.0057g / mL of polypropylene, 0.0019g / mL of polyethylene glycol, 0.0008g / mL of hydroxypropyl methyl cellulose and 0.0002g / mL of chitosan. The gel temperature of the in-situ gel preparation is 34 DEG C, is close to the body temperature of a human body, and accords with the requirements of in vivo gel for injection; gel corrosion and drug release are carried out at a similar velocity; the drug is controlled to be slowly released by gel corrosion; the thermosensitive in-situ gel preparation has good drug slow-release and sustained-release effects; and the medication safety is good.

The invention discloses a disease-resistant type feed additive capable of promoting digestion and absorption and an application of the disease-resistant type feed additive, and belongs to the technical field of feed additives. The disease-resistant type feed additive capable of promoting digestion and absorption comprises the following raw materials of licorice roots, medicated leaven, endotheliumcorneum gigeriae galli, pumpkin seeds, azedarach, pseudobulbus cremastrae seu pleiones, umbellate rockjasmine herbs, rhizoma fagopyri cymosi roots, carboxymethyl-beta-cyclodextrin and sodium polyacrylate. The disease-resistant type feed additive capable of promoting digestion and absorption is applied to an ecological breeding feed for mutton sheep; after the ecological breeding feed for mutton sheep, prepared from the disease-resistant type feed additive capable of promoting digestion and absorption, is used, the average daily feed intake and the average daily gain of the mutton sheep and the digestibility of each nutrient substance can be effectively increased, and the prevalence rate can be reduced.

The invention relates to a cationic adhesion type mycophenolate mofetil nano eye drop, which comprises mycophenolate mofetil of which the mass percentage concentration is 1 percent, proper amount of osmotic pressure modifying agent and pH modifying agent. The eye drop is characterized in that the eye drop also comprises chitosan, Pluronic F-68 and phospholipid, wherein the mass percentage concentration of the phospholipids in the eye drop is between 0.2 and 2 percent; the mass percentage concentration of the Pluronic F-68 in the eye drop is between 0.5 and 4 percent; the mass percentage concentration of the chitosan in the eye drop is between 0.5 and 4 percent; the molecular weight of the chitosan is between 5,000 and 300,000; the deacetylation degree is more than 85 percent; and the grain diameter of the mycophenolate mofetil is between 10 and 700 nm. The eye drop has the characteristics that: the mycophenolate mofetil with nanometer grain diameter improves the medicament solubility,the safety and the effectiveness; mycophenolate mofetil medicament particles are charged with positive charges so as to be favorable for improving the cornea absorption of the medicament, improving the medicament effect, prolonging the medicament duration, and greatly improving the cornea adhesion.

A cationic adhesive-type natamycin nanometer eye drop comprises natamycin, a proper amount of osmoregulator and pH regulator. The eye drop is characterized by further comprising chitosan, pluronic F-68 and phospholipid, wherein, the mass percent concentration of the phospholipid in the eye drop is 0.01-2%, the mass percent concentration of the pluronic F-68 in the eye drop is 0.1-20%, and the masspercent concentration of the chitosan in the eye drop is 0.01-4%. The molecular weight of the chitosan is 5000-300000, and the deacetylation degree of the chitosan is greater than 85%. The natamycinnanometer eye drop is characterized by making a common natamycin suspension into suspension particles with the diameter ranging from 10nm to 1000nm, thus increasing solubility of the eye drop and enhancing safety and effectiveness. The natamycin particles of the common suspension are modified by the phospholipid and the chitosan to cause the particles to be positively charged, which is helpful toimprove absorption of the eye drop by cornea, enhances drug effect and prolongs the action time of the eye drop. And the chitosan has bioadhesion function, which enhances the adhesiveness between medicinal particles and the cornea.

The invention discloses a cadmium-contaminated soil remediation fixing agent based on microorganism assembly synthesis as well as preparation and an application method thereof. At present, multiple nano phosphate fixing agents for cadmium-contaminated soil remediation are easily dispersed and lost, underground water eutrophication is caused, and further secondary pollution is caused. Aiming at solving the problems, nano-hydroxyapatite is taken as a central substance, aspergillus niger hyphae are adopted for wrapping the nano-hydroxyapatite, and a cadmium-contaminated soil remediation fixing agent specific to high contamination and high acidity is prepared, so that the problem of excessive dispersion in practical application is solved. A synthesized product is uniformly mixed with cadmium-contaminated soil in a certain rate, and effective state cadmium content is reduced by 67-86%. The cadmium-contaminated soil remediation fixing agent disclosed by the invention is simple in preparation process, low in cost, efficient, non-toxic and biodegradable and has no secondary pollution, thereby being an environment-friendly fixing agent.