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Calcium alginate composite microspheres for stabilizing water-in-oil type Pickering emulsion and preparation method thereof

A technology of Pickering emulsion and calcium alginate, which is applied in the field of calcium alginate composite microspheres and its preparation, can solve the problems of limited application, reduction of hydrophilicity, inability to stabilize water-in-oil Pickering emulsion, etc., and achieve Broad application prospects, strong practicability, and the effect of improving mechanical strength

Active Publication Date: 2019-03-01
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since calcium alginate microspheres are very hydrophilic, usually only oil-in-water Pickering emulsions can be stabilized; this limits the application of calcium alginate microspheres as emulsifiers for Pickering emulsion particles
In the prior art, the hydrophilicity of calcium alginate is reduced by coating with relatively hydrophobic chitosan, and calcium alginate microspheres coated with chitosan are used to stabilize the oil-in-water Pickering emulsion, although it can be used as a drug carrier Encapsulate oil-soluble drugs in the inner phase of the emulsion, but chitosan-coated calcium alginate microspheres cannot stabilize the water-in-oil Pickering emulsion, so they cannot be used as a carrier for encapsulating water-soluble drugs

Method used

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  • Calcium alginate composite microspheres for stabilizing water-in-oil type Pickering emulsion and preparation method thereof
  • Calcium alginate composite microspheres for stabilizing water-in-oil type Pickering emulsion and preparation method thereof
  • Calcium alginate composite microspheres for stabilizing water-in-oil type Pickering emulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] (1) Alkylsilane-grafted TiO 2 Preparation of nanoparticles: (1) 1 g of commercially available TiO with a particle size of 25 nm 2 Nanoparticles were added to 15 mL of 30% by volume H 2 o 2 solution, ultrasonically dispersed for 5 min to obtain a dispersion; (2) sealed the dispersion and placed it in a dark place with magnetic stirring at 500 rpm for 2 h, unsealed and dried at 40 °C to obtain hydroxylated TiO 2 Nanoparticle powder; (3) The dried hydroxylated TiO 2 Nanoparticle powder was added to a mixture of 0.2 mL octaalkyltrichlorosilane and 19.8 mL n-hexane, ultrasonically dispersed for 5 min, and magnetically stirred at 500 rpm for 8 h, during which n-hexane was added to maintain the initial liquid level; (4) the previous The dispersion obtained in the step was centrifuged at 12000 rpm for 5 minutes at 4 °C, and the precipitate was dried at 40 °C to obtain the alkylsilane-grafted TiO 2 nanoparticles.

[0048] (2) Preparation of water-in-oil sodium alginate Pick...

Embodiment 2

[0053] (1) Alkylsilane-grafted SiO 2 Preparation of nanoparticles: (1) 1.8 g of commercially available SiO with a particle size of 25 nm 2 Nanoparticles were added to 15 mL of 30% by volume H 2 o 2 In the solution, ultrasonically disperse for 10 min to obtain a dispersion; (2) Seal the dispersion and place it in a dark place with magnetic stirring at 800 rpm for 6 h, unseal and dry at 60 °C to obtain hydroxylated SiO 2 nanoparticle powder; (3) the dried hydroxylated SiO 2 Nanoparticle powder was added to a mixture of 1 mL octaalkyltrichlorosilane and 19 mL n-hexane, ultrasonically dispersed for 10 min, and magnetically stirred at 800 rpm for 12 h, during which n-hexane was added to maintain the initial liquid level; (4) the previous The dispersion obtained in the step was centrifuged at 15000 rpm for 15 minutes at 4 °C, and the precipitate was dried at 60 °C to obtain the SiO grafted with alkylsilane. 2 nanoparticles.

[0054] (2) Preparation of water-in-oil sodium algina...

Embodiment 3

[0059] (1) Alkylsilane-grafted Fe 3 o 4 Preparation of nanoparticles: (1) 1.5 g of commercially available Fe with a particle size of 25 nm 3 o 4 Nanoparticles were added to 15 mL of 30% by volume H 2 o 2 solution, ultrasonically disperse for 8 min to obtain a dispersion; (2) seal the dispersion and place it in a dark place with magnetic stirring at 700 rpm for 4 h, unseal and dry at 50 °C to obtain hydroxylated Fe 3 o 4 Nanoparticle powder; (3) the hydroxylated modified Fe after drying 3 o 4Nanoparticle powder was added to a mixture of 0.5 mL octaalkyltrichlorosilane and 19.5 mL n-hexane, ultrasonically dispersed for 8 min, and magnetically stirred at 700 rpm for 10 h, during which n-hexane was added to maintain the initial liquid level; (4) the previous The dispersion obtained in the step is centrifuged at 13000 rpm for 10 min at 4 °C, and the precipitate is dried at 50 °C to obtain the alkylsilane-grafted Fe 3 o 4 nanoparticles.

[0060] (2) Preparation of water-in...

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Abstract

The invention discloses calcium alginate composite microspheres for stabilizing water-in-oil type Pickering emulsions and a preparation method thereof, belonging to the technical field of material polymers. Alkylsilane-grafted inorganic nanoparticles are coated on the surface of calcium alginate microspheres to form calcium alginate composite microspheres. The particle size distribution of the microspheres is 2-8 μm; it has a core-shell structure, the core is hollow, and the shell has two layers. The total thickness of the two-layer shell is 1~1.5µm, calcium alginate is the inner shell, and inorganic nanoparticles are assembled to form the outermost shell; it overcomes the fact that chitosan coated on the surface of calcium alginate microspheres can only stabilize the oil-in-water type Pickering emulsion, as a drug carrier, can only encapsulate oil-soluble drugs but not water-soluble drugs. The use of improved emulsion polymerization to prepare calcium alginate composite microspheres also has the biocompatibility of calcium alginate, Adhesion and encapsulation of protein macromolecules can stabilize the water-in-oil Pickering emulsion very well. It can widely expand the application of Pickering emulsion as a drug carrier in the fields of biomedicine, cosmetics industry, food industry and enzyme engineering.

Description

technical field [0001] The invention belongs to the technical field of materials, and in particular relates to a calcium alginate composite microsphere used for stabilizing water-in-oil Pickering emulsion and a preparation method thereof. Background technique [0002] Pickering emulsions are emulsions stabilized by solid particles, which are composed of water phase, oil phase and solid particles. Generally, hydrophilic solid particles can stabilize oil-in-water emulsions, and hydrophobic solid particles can stabilize water-in-oil emulsions. Compared with emulsions stabilized by traditional surfactants, Pickering emulsions have the advantages of high stability, low toxicity, and environmental friendliness, and have been widely used in drug delivery, cosmetics, and food industries. [0003] There are many solid particles used to stabilize Pickering emulsions, mainly divided into inorganic particles and organic particles. Considering limitations such as toxicity, biodegradabi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/16C08J3/12C08L5/04B01J13/14A61K9/107A61K47/36A61K47/02A61K8/73A61K8/06A61K8/19A61K8/25A61K8/29A61Q19/00
CPCA61K8/06A61K8/19A61K8/25A61K8/29A61K8/73A61K9/107A61K47/02A61K47/36A61K2800/10A61Q19/00B01J13/14C08J3/12C08J3/16C08J2305/04
Inventor 孟涛杨鑫白瑞雪郭婷
Owner SOUTHWEST JIAOTONG UNIV
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