The invention discloses 2-(1',2',3'-triazolyl-4'-oxymethylenepyridyl)-1,3,4,6-O-acetyl-D-glucose with anti-rectal
cancer activity. The 2-(1',2',3'-triazolyl-4'-oxymethylenepyridyl)-1,3,4,6-O-acetyl-D-glucose has a core structure of 1,3,4,6-O-acetyl-D-glucose subjected to 1,2,4-
triazole derivative 2-site substitution. The above compound has good rectal
cancer cell inhibition activity and can be used as a
drug for resisting rectal
cancer. A compound synthesis method comprises that 2-amino-D-glucose
hydrochloride and an azidation
reagent as raw materials undergo a reaction under alkaline conditions to produce a 2-azido-1,3,4,6-O-acetyl-D-glucose intermediate, 3-
propargyl bromide and aromatic
methanol undergo a reaction under the action of
sodium hydride to produce aromatic
propargyl ether, and the 2-azido-1,3,4,6-O-acetyl-D-glucose intermediate and the aromatic
propargyl ether undergo a click reaction in a
solvent in the presence of monovalent
copper as a catalyst to produce 2-(1', 2', 3'-triazolyl-4'-oxymethylenepyridyl)-1,3,4,6-O-acetyl-D-glucose.