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Fluorescent ion probe reagent used in cadmium ion detection and preparation method thereof

A technology of fluorescent ions and cadmium ions, which is applied in the field of fluorescent ion probe reagents for cadmium ion detection and its preparation, achieves high sensitivity, simple synthetic route, and non-destructive effects

Inactive Publication Date: 2009-10-14
NANKAI UNIV
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

However, among the many fluorescent probes for metal ions, there are few reagents with special selectivity for cadmium ions.

Method used

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  • Fluorescent ion probe reagent used in cadmium ion detection and preparation method thereof
  • Fluorescent ion probe reagent used in cadmium ion detection and preparation method thereof
  • Fluorescent ion probe reagent used in cadmium ion detection and preparation method thereof

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Embodiment

[0025] 1) Synthesis of 8-hydroxyquinoline alkynyl intermediate

[0026] Under nitrogen protection, 7.3g (0.05mol) 8-hydroxyquinoline, 21g (0.15mol) anhydrous potassium carbonate and 16.5mL (0.2mol) 3-bromopropyne were added to 100mL anhydrous N,N'-dimethyl In methyl formamide, react at room temperature for 24 hours, remove the insoluble matter by filtration, distill the filtrate under reduced pressure to remove the solvent to obtain a solid, dissolve the obtained solid in chloroform, extract three times with 50 mL of water, collect the organic phase and use After drying over sodium sulfate, it is concentrated by distillation under reduced pressure, using a mixture of chloroform and methanol with a volume ratio of 200:3 as a developing solvent, and then separated by a 200-300 mesh silica gel column to obtain 8-hydroxyquinoline base intermediate;

[0027] 2) Synthesis of 8-hydroxyquinolyl and triazolyl-modified β-cyclodextrin derivatives

[0028] Under nitrogen protection, 1.3...

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Abstract

The invention relates to a fluorescent ion probe reagent used in cadmium ion detection, which is the derivate of 8-hydroxyquinoline and triazolyl modified Beta-cyclodextrin; wherein 8-hydroxyquinoline is adopted as probe molecule, and nitrogen oxide atom in quinoline ring and nitrogen atom in triazole ring are taken as the bonding lotus of cadmium (II) ion. The method comprises the steps of: synthesizing 8-hydroxyquinoline alkynyl intermediate by 8-hydroxyquinoline, 3-propargyl bromide and the like firstly; and synthesizing a target product by the intermediate, mono-6-deoxy-6-azido-Beta-cyclodextrin, sodium ascorbate and the like. The invention has the advantages that as water-soluble cadmium ion fluorescent probe, the prepared cyclodextrin derivate has simple synthesizing process and high yield, and is suitable for further enlargement synthesis and practical production application; the sensing operation to cadmium ion is simple and practical; and the sensitivity is high and displayed by fluorescence spectrum. As cadmium ion fluorescent probe, the invention exactly explains the coordinate bonding mechanism to cadmium (II) ion and has wide application prospect.

Description

【Technical field】 [0001] The invention relates to the field of fluorescent probes for detecting heavy metal ions, in particular to a fluorescent ion probe reagent for detecting cadmium ions and a preparation method thereof. 【Background technique】 [0002] Fluorescent probes refer to molecules that can change the fluorescent signal when a certain physical property of a substance or system changes in a specific system. Fluorescent ion probe is a kind of fluorescent probe, which can convert the molecular / ion binding information into an easily detectable fluorescent signal, and then obtain the recognition function of ions. As a sensitive detection method with wide application value, fluorescent ion probe has advantages that other analytical methods such as atomic absorption spectroscopy, ion selective electrode analysis and other traditional methods cannot match, that is, the change of fluorescence intensity can directly reflect the existence of ions , and has high sensitivity,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/16G01N21/64
Inventor 刘育张瀛溟李志强
Owner NANKAI UNIV
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