Benzoin oxime derivative and preparation method thereof

Abstract

The invention relates to a benzoin oxime derivative and a preparation method thereof. A structural formula of the benzoin oxime derivative is shown in the specification. The preparation method comprises the following steps: reacting malonate with propargyl bromide in anhydrous acetonitrile under the catalysis of sodium hydride to obtain a white solid product; by taking triethylamine as alkali, reacting the white solid product with phenylethynyl bromine or substituted phenylethynyl bromine in anhydrous acetonitrile under the catalysis of Pd(PPh3)2Cl2 / CuI to obtain a light brown solid product; reacting the light brown solid product with benzoin oxime in toluene at 95-105 DEG C to obtain the benzoin oxime derivative. A brand new synthetic method of polysubstituted benzoin oxime is provided, and a series of new benzoin oxime derivatives are generated. Compared with normal benzoin oxime derivatives, the benzoin oxime derivative prepared by virtue of the preparation method has relatively complex and diverse structures by virtue of multiple cycles, and presents relatively wide application prospects in chemical industry production and clinic medicines.

Description

technical field [0001] The invention relates to the field of organic compounds, in particular to a benzoin oxime derivative and a preparation method thereof. Background technique [0002] Benzoin, benzoin oxime and their derivatives are widely used in industrial production and scientific research. For example, benzoin, benzoin oxime and their derivatives are important intermediates in organic synthesis and fine chemicals, and are widely used in chemical industry, medicine, spices, chelating agents, coatings and other fields. In view of the special importance of benzoin, benzoin oxime and their derivatives, how to expand the synthetic route of benzoin oxime and its derivatives has aroused countless organic synthesizers and chemists to actively think, and came up with some very effective methods. [0003] The common synthetic methods of benzoin and benzoin oxime are: [0004] 1. Using sodium cyanide and potassium cyanide as catalysts: [0005] With sodium cyanide and potass...

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Problems solved by technology

[0005] With sodium cyanide and potassium cyanide as catalysts, benzaldehyde molecules condense to generate benzoin, and then use benzoin to react with hydroxylamine hydrochloride under the action of alkali anhydrous potassium carbonate to prepare benzoin oxime, but sodium cyanide and potassium cyanide are highly toxic. Poisons pose a huge threat to the safety of the human body and the environment, and are inconvenient to use

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