The invention discloses a preparation method of a
molecularly imprinted polymer based on the
click chemistry. The method comprises the following steps: synthesizing
silicon dioxide
pellets with grafted double bonds; dissolving a template molecule and a
functional monomer in a
solvent, performing
self assembly, and sufficiently shaking up the solution; adding the
silicon oxide microspheres with the grafted double bonds, a cross-linking agent containing sulfhydryls, an initiator and a dispersant into the self-assembled solution, and performing
polymerization reaction, thereby obtaining a
molecularly imprinted polymer coated with template molecules on the surface; and washing the
molecularly imprinted polymer coated with template molecules on the surface, removing the template molecules which coat the surface, and
drying, thereby obtaining the molecularly imprinted
polymer. According to the preparation method of the molecularly imprinted
polymer based on
click chemistry, during a preparation process, the cross-linking agent containing the sulfhydryls is used, and a sulfhydryl-alkenyl
click chemistry and
molecular imprinting combination technology is utilized, so that
reaction conditions are mild, reaction is rapid, and the template
molecule adsorption capacity and template molecule selection performance of the molecularly imprinted
polymer prepared by the preparation method are greatly improved.