52 results about "Propanethiol" patented technology

The invention discloses a preparation method of ticagrelor. The preparation method comprises the following steps of: carrying out a cyclization reaction between 5-amino-1,4-di-substituted-1,2,3-triazole (II) and a dialkyl carbonate (III), thereby obtaining 9-substituted-2,6-dihydroxy-8-azaguanine (IV), chlorinating the intermediate (IV) to obtain 9-substituted-2,6-dichloro-8-azaguanine (V), carrying out an amination reaction between the intermediate (V) and trans-(1R, 2S)-2-(3,4-difluorophenyl) cyclopropylamine (VI) to generate 9-substituted-6-amino substituent-2-chloro-8-azaguanine (VII), and carrying out a propylthiolation reaction between the intermediate (VII) and propanethiol (VIII) to obtain the ticagrelor (I). The preparation method disclosed by the invention is simple in process, and high in chemical and chiral purity, and provides a new preparation way for industrial production of the ticagrelor.

This invention has disclosed a pseudomonas putida strain as well as its microbial inoculum and application. Such strain is named as Pseudomonas putida S-1, which was preserved at China Center for Type Culture Collection (CCTCC) on Sep. 25, 2013 with the deposit number of CCTCC NO: M2013444. The strain of this invention takes isopropanol, ethanal, dipropyl disulfide, diethyl disulfide and propanethiol as the sole carbon source for effective degradation of substrate simultaneously with the energy growth. Furthermore, it can obtain a perfect growth in different cultivation modes owing to high substrate tolerance, which has laid down a solid foundation for engineering application for elimination of VOCs contained exhaust gas by means of biological purification.

The invention relates to the technical field of a high polymer material antistatic agent, and particularly relates to a quaternary ammonium salt hyperbranched antistatic agent. Propargyl alcohol reacts with succinic anhydride so as to obtain a modified monomer R1, the R1 reacts with 3-(dimethylamino)-1-propanethiol so as to obtain a modified monomer R2, the R2 reacts with a hydroxyl-terminated hyperbranched polymer so as to obtain a dimethyl amine-terminated hyperbranched structure, and then the dimethyl amine-terminated hyperbranched structure reacts with alkyl chloride so as to obtain the quaternary ammonium salt hyperbranched antistatic agent. The molecules of the antistatic agent contain more effective active groups, the utilization rate of the molecules is relatively high, the surface water absorbability of the antistatic agent in a substrate is relatively strong, and correspondingly the antistatic agent has a relatively good antistatic effect; the antistatic agent has relatively good compatibility with a medium and very good dispersibility.

The invention discloses a hole-filling electroplating leveling agent, a preparation method thereof and an electroplating solution using the hole-filling electroplating leveling agent, and relates to the technical field of electroplating. The hole-filling electroplating leveling agent includes ingredients 3-(dimethylamino)-1-propanethiol, piperazine, binary epoxy compound, and the 3-(dimethylamino)-1-propanethiol The molar mass ratio of mercaptan, piperazine and binary epoxy compound is 1~3:2~4:4~6; described binary epoxy compound has the following structural formula: wherein, R is the connection of non-epoxy group group. The hole-filling electroplating leveling agent of the present invention improves the interaction between the leveling agent molecule and the accelerator and inhibitor by introducing a sulfur atom-containing functional group into the leveling agent molecule, so that the three types of additives can better cooperate with each other , so that the prepared electroplating solution can achieve excellent hole filling performance.

The invention discloses a loofah sponge saddle for a long-distance bicycle and a preparation method. The composition comprises raw materials in parts by weight as follows: 100-200 parts of loofah sponge fibers, 4-6 parts of trimethyl propanethiol, 5-9 parts of cyclohexane dicarboxylic ester, 30-50 parts of chitosan, 50-70 parts of bamboo charcoal micro-powder, 2-4 parts of nano silver, 50-100 parts of rubber powder, 40-50 parts of negative-ion polypropylene staple fibers, 50-100 parts of resin with the viscosity of 3000-3200, 30-50 parts of waterproof resin slurry, 3-5 parts of citric acid, 2-6 parts of a silane coupling agent and a proper amount of deionized water. A trimethyl propanethiol-modified loofah sponge fiber high-polymer material is matched with the negative-ion polypropylene staple fibers, the chitosan, the bamboo charcoal micro-powder and the nano silver and combined with the resin, the high-breathability, high-elasticity, high-buffering and wear-resistant loofah sponge saddle for the bicycle is prepared, and the comfort feeling of a rider is enhanced.

The invention provides a tinning brightener and a preparing method thereof. Raw materials include glutaraldehyde, dyhydroxy propanethiol, cinnamyl aldehyde, alkylphenol ethoxylates and water. The rawmaterials include 55-80 parts of glutaraldehyde, 60-90 parts of dyhydroxy propanethiol, 5-10 parts of cinnamyl aldehyde, 55-85 parts of alkylphenol ethoxylates and 300-400 parts of water. Through cooperation of mixing, cooling, additive adding, carrier brightener adding and product forming work processes, the situation that Sn2+ is likely to be oxidized by an anode during electrolysis is preventedthrough dyhydroxy propanethiol, and long-term stability of a plating solution is improved; meanwhile, the chemical activity of glutaraldehyde carbonyl is particularly high, meanwhile, the Sn2+ adsorption capability is improved, and then brightness of the tinning brightener is improved; meanwhile, influences are generated to glutaraldehyde adsorption from cinnamyl aldehyde, the potential, adsorbedto the surface of an electrode, of the glutaraldehyde becomes narrow, accordingly, fine crystalline particles are generated, an auxiliary function is achieved for clad layer brightness increasing, and brightness of the tinning brightener is improved.

The invention relates to a detection method for metabolites in urine. The method includes (1) a step of removing impurities from a urine sample, namely a step of removing urea, sulfur and phosphorus and precipitating protein to obtain urine C; (2) a drying step, namely a step of drying the urine C to obtain urine residues D; (3) a step of oximation, namely a step of subjecting beta-carbonyl in acid or alcohol metabolites in the urine residues D to oximation by utilizing an oximation agent to obtain urine E; (4) a step of derivatization, namely a step of subjecting the urine E to derivatization with an derivatization agent to obtain a urine sample F to be detected, with the derivatization agent being an agent mixture comprising a silanization agent, a catalyst and a catalyst stabilizer, and with the catalyst stabilizer being selected from dithioerythritol, dithiothreitol, 1-propanethiol, ethanethiol and 2-mercaptoethanol; and (5) a step of detection, namely a step of detecting the urine sample F to be detected by adopting a gas chromatography-mass spectrography process. The method has advantages of a low sample using amount, simple pretreatment, short time, capability of detecting a plurality of varieties of compounds, rapid and accurate result analysis, and the like.

The invention provides a novel preparation method of albendazole. According to the invention, a novel synthetic route of albendazole is provided, wherein 2-nitro-5-chloroaniline is used as a startingmaterial and is subjected to reactions of substitution, condensation, reduction and cyclization to obtain high-purity albendazole. The method is characterized in that: the 2-nitro-5-chloroaniline is subjected to substituted reaction, and is subjected to condensation reaction with halogenated n-propane to obtain 2-nitro-5-albendazole aniline, which avoids the use of propanethiol with a high price and a stimulating odor. The use of a high-risk hydrogenation reduction process is avoided, a vulcanization alkali reduction process which is cheap and easily available in raw materials is used, a set of non-toxic treatment schemes for reducing layered waste water are provided, and meanwhile, secondary sodium thiosulfate can be obtained and the waste is turned into wealth. According to the method, the yield is high, the safety risk is low, the industrial production is facilitated, the content of the prepared albendazole is high, the content of single impurities is small, and the latest standardssuch as the US Pharmacopeia and the European Pharmacopoeia are met.

The invention relates to a durian flavor essence, which is composed of the following components: propanethiol; 3-hydroxy-2-butanone; hexadecanoic acid; octadecanoic acid; 2-methyl-ethyl butyrate; 2-methyl-butyric acid methyl butyrate; ethyl propionate; ethyl acetate; ethyl butyrate; propyl caproate; ethyl heptanoate; ethyl octanoate; -1,2,4-Trithiolane; Methyl 3-Methylthiopropionate; Diethyldisulfide; Propyl Trisulfide; Diallyl Sulfide; Ethanethiol; Propylene Glycol; Durian Extract. Durian flavor essence has a natural, rich and non-irritating durian flavor, which satisfies people's pursuit of flavor and expands the use range of durian; at the same time, the product is resistant to high temperature and can effectively supplement the loss of durian flavor during thermal processing, thereby enhancing the food's quality. Durian characteristic flavor.

The invention relates to a polyurethane type high-refraction optical resin monomer containing sulfur and a preparation method of the polyurethane type high-refraction optical resin monomer. The preparation method includes: using mercaptoethanol as the raw material to synthesize a 2, 3-dimercapto ethyl sulfo-propanethiol monomer through sulfo-polyol and sulfo-polymercaptan, and allowing the 2, 3-dimercapto ethyl sulfo-propanethiol monomer to have a polymerization addition reaction with isocyanate to prepare an optical resin lens with high refraction rate and high light transmittance.\The polyurethane type optical resin monomer prepared by the method is high in purity, and the monomer and the lens are high in refraction rate, high in light transmittance, and the like. The light transmittance of the monomer is not smaller than 89%, the refraction rate of the monomer is not smaller than 1.66, the abbe number of the monomer is not smaller than 31, and the yellow index of the monomer is not larger than 0.8. The light transmittance of the lens is not smaller than 90%, the refraction rate of the lens is not smaller than 1.67, the yellow index of the lens is not larger than 1.55, and the surface hardness of the lens is 2H.

2,3-epoxy-2-propylsulfone-5,8-dimethoxy-1,4-naphthoquinone, a preparation method thereof, and a medicine containing the same; it belongs to the technical field of medicine. Its structural formula is: The method of the present invention: 1. Dissolve 5,8-dimethoxy-1,4 naphthoquinone in methanol, add 1-propanethiol, react at room temperature, then add sodium dichromate and concentrated sulfuric acid , continue to react, then extract with dichloromethane and saturated saline, dry over anhydrous sodium sulfate, filter, and concentrate to dryness; 2, then dissolve in chloroform, continue to add 3-chloroperoxybenzoic acid, react at room temperature, react Add 5% NaHCO after complete 3 After neutralizing the excess m-chloroperoxybenzoic acid in the solution, the reaction was terminated, extracted with dichloromethane and saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated to dryness. Application of the compound and the pharmaceutical composition of the present invention in the preparation of medicines for treating liver cancer.

The invention discloses a surface-enhanced Raman spectrum base material, a preparation method and an application. The base material is a three-layer composite structure, the lower layer is a single-layer film of Au@Ag nanoparticles, the middle layer is a molecular layer of propanethiol modified on the Au@Ag film, and the upper layer is a polydimethylsiloxane film with a thickness of 200-400nm. In the three-layer composite structure substrate material provided by the invention, the polydimethylsiloxane film enriches the gaseous molecules of single-ring aromatic hydrocarbons in the flowing gas through physical action, and propanethiol adsorbs the molecules to the surface of the Au@Ag film for enhancement. Therefore, it can effectively enrich, fix, and detect toxic air pollutants, especially for toluene, benzene, and xylene in the mobile gas phase, and its detection signal intensity is increased by more than 50 times. The detection of related pollutants provides a more sensitive new method.

The invention relates to the technical field of a high polymer material antistatic agent, and particularly relates to a quaternary ammonium salt hyperbranched antistatic agent. Propargyl alcohol reacts with succinic anhydride so as to obtain a modified monomer R1, the R1 reacts with 3-(dimethylamino)-1-propanethiol so as to obtain a modified monomer R2, the R2 reacts with a hydroxyl-terminated hyperbranched polymer so as to obtain a dimethyl amine-terminated hyperbranched structure, and then the dimethyl amine-terminated hyperbranched structure reacts with alkyl chloride so as to obtain the quaternary ammonium salt hyperbranched antistatic agent. The molecules of the antistatic agent contain more effective active groups, the utilization rate of the molecules is relatively high, the surface water absorbability of the antistatic agent in a substrate is relatively strong, and correspondingly the antistatic agent has a relatively good antistatic effect; the antistatic agent has relatively good compatibility with a medium and very good dispersibility.

The invention belongs to the technical field of organic sulfide detection, and particularly relates to a detection method of propanethiol. The detection method comprises the following steps that S1, AuNPs-Ag wires are prepared, wherein the AuNPs-Ag wire preparation process comprises the steps of cleaning of silver wires, corrosion of the silver wires and modification of the silver wires; S2, the propanethiol is detected, wherein the propanethiol detection process comprises the steps of extraction and surface enhanced Raman detection. According to the detection method of the propanethiol, an SPME-SERS coupling technique is adopted, the technology is simple, the complex sample pretreatment process can be reduced or even omitted, the analysis time can be shortened, the detection sensitivity is high, the limit of detection to the propanethiol can reach 10-13 M, and the detection method of the propanethiol is suitable for in-situ rapid analysis of field spots.