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Preparation method of molecularly imprinted polymer based on click chemistry

A molecular imprinting and click chemistry technology, applied in chemical instruments and methods, other chemical processes, etc., can solve the problems of harsh conditions and long reaction time of molecularly imprinted polymerization reaction, and achieve the improvement of adsorption capacity and selectivity, fast reaction, and high reaction time. mild conditions

Active Publication Date: 2016-10-12
FOSHAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, the reaction conditions of traditional molecular imprinting polymerization are harsh and the reaction time is long.

Method used

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  • Preparation method of molecularly imprinted polymer based on click chemistry
  • Preparation method of molecularly imprinted polymer based on click chemistry
  • Preparation method of molecularly imprinted polymer based on click chemistry

Examples

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preparation example Construction

[0027] The preparation method of molecularly imprinted polymer based on click chemistry disclosed in the present invention comprises the following steps:

[0028] (1) Synthesis of silica microspheres grafted with double bonds;

[0029] (2) Dissolving template molecules and functional monomers in a solvent for self-assembly and shaking well;

[0030] (3) Add silica microspheres grafted with double bonds, a mercapto crosslinking agent, an initiator and a dispersant to the solution in step (2) to cause a polymerization reaction to obtain molecularly imprinted polymerization of surface-coated template molecules thing;

[0031] (4) washing the molecularly imprinted polymer whose surface is coated with the template molecule obtained in step (3), removing the coated template molecule therein, and drying to obtain the molecularly imprinted polymer;

[0032] In the present invention, the preparation method of the double bond-grafted silica microspheres in step (1) is as follows: acti...

Embodiment 1

[0038] This example describes in detail the preparation method of pyrimethamine molecularly imprinted polymers based on click chemistry, using pyrimethamine as a template molecule and methacrylic acid as a functional monomer, but this does not limit the scope of protection of the present invention . The template molecules and functional monomers are not limited thereto.

[0039] see figure 1 , which is a schematic diagram of the preparation process of the click chemistry-based pyrimethamine molecularly imprinted polymer of the present invention. The preparation method of the pyrimethamine molecularly imprinted polymer based on click chemistry of the present invention comprises the following steps:

[0040] (1) Synthesis of silica microspheres grafted with double bonds

[0041] Weigh 5.0% silica and pour it into a 250mL round bottom flask, add 150mL of 8mmol / L hydrochloric acid at 80°C for 8h for activation, and then wash with deionized water until neutral. Dry in vacuum at...

Embodiment 2

[0056] The steps of this example are substantially the same as those of Example 1, except that the ratio of the template molecule pyrimethamine to the functional monomer methacrylic acid in step (2) is different.

[0057] Specifically, in step (2), 0.24 g of the template molecule pyrimethamine and 0.516 mL of the functional monomer methacrylic acid were dissolved in 10 mL of dimethyl sulfoxide and 20 mL of toluene, ultrasonically dispersed, and allowed to stand overnight.

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Abstract

The invention discloses a preparation method of a molecularly imprinted polymer based on the click chemistry. The method comprises the following steps: synthesizing silicon dioxide pellets with grafted double bonds; dissolving a template molecule and a functional monomer in a solvent, performing self assembly, and sufficiently shaking up the solution; adding the silicon oxide microspheres with the grafted double bonds, a cross-linking agent containing sulfhydryls, an initiator and a dispersant into the self-assembled solution, and performing polymerization reaction, thereby obtaining a molecularly imprinted polymer coated with template molecules on the surface; and washing the molecularly imprinted polymer coated with template molecules on the surface, removing the template molecules which coat the surface, and drying, thereby obtaining the molecularly imprinted polymer. According to the preparation method of the molecularly imprinted polymer based on click chemistry, during a preparation process, the cross-linking agent containing the sulfhydryls is used, and a sulfhydryl-alkenyl click chemistry and molecular imprinting combination technology is utilized, so that reaction conditions are mild, reaction is rapid, and the template molecule adsorption capacity and template molecule selection performance of the molecularly imprinted polymer prepared by the preparation method are greatly improved.

Description

technical field [0001] The invention relates to the field of molecularly imprinted polymers, in particular to a method for preparing molecularly imprinted polymers based on click chemistry. Background technique [0002] Pyrimethamine is also widely used in animal products and aquatic product breeding. Appropriate use can enhance the disease resistance of animals. It is a broad-spectrum antibacterial veterinary drug, mainly used to prevent chicken coccidiosis, fowl cholera and pullorum of piglets, etc. . However, pyrimethamine has a high degree of accumulation in aquatic products. If it exceeds a certain range, human consumption will destroy the human hematopoietic system, cause hemolytic anemia, and even cause potential carcinogenicity. At the same time, it has a direct effect on the central nervous system. Toxic effects. The United Kingdom and the United States have already clearly stipulated that pyrimethamine and other feed additives are prohibited as feed additives. Ja...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F285/00C08F220/38C08F220/06C08F292/00C08F230/08C08J9/26B01J20/26B01J20/30
CPCB01J20/268C08F285/00C08F292/00C08J9/26C08F230/08C08F220/382
Inventor 陈晓刚陈忻梁勇詹根权
Owner FOSHAN UNIVERSITY
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