The invention relates to a method for carrying out oxidation treatment on organic waste water by utilizing a three-dimensional electrode electro-fenton and a device thereof. The device comprises a reactor shell, a carbon material cathode, an iron plate anode, a three-dimensional particle electrode of a fixed bed, a direct-current voltage-stabilizing power supply, a microporous aeration plate and an air pump, wherein a reactor consists of a reaction chamber and a gas chamber; the carbon material cathode, the iron plate anode and the particle electrode are positioned in the reaction chamber at the upper part of the reactor; and the gas chamber is formed between the bottom of the reactor and the microporous aeration plate. After direct current is introduced, the iron anode is oxidized to generate iron ions, oxygen in the gas chamber is reduced on the surface of the cathode to generate hydrogen peroxide, and the iron ions and the hydrogen peroxide form a fenton reagent to oxidize and remove organic matters in waste water; and simultaneously, due to the particle electrode, the contact area and the contact time of the waste water and the fenton reagent are increased, and the mass transfer effect of the waste water in the reactor is reduced. The invention is applicable to treatment of various types of organic waste water, the equipment is compact, the operation is easy, the whole reactor is easy to control, and the requirements of an actual water treatment unit are met.