36 results about "Amantidine" patented technology

This invention concerns adamantanamines (e.g. memantine, amantadine, and rimantadine) and neramexane salts of thiomolybdic and thiotungstic acids, including their preparation and pharmaceutical compositions, as dual acting drugs. These salts are used to treat or potentially arrest the neurodegenerative pathophysiology, clinical signs and symptoms of dementia of the Alzheimer's type, Parkinson's, Huntington's, AIDS-related dementia and Schizophrenia and its cognitive deficits. Additional uses of these derivatives include antiviral activity. The novel compositions of the present invention appear particularly useful in enhancing the therapeutic benefits of copper-sequestering tetrathiomolybdates in treating elevated copper-induced toxicities in neurologically presenting Wilson's disease, and in treating diseases of the inflammatory etiology and abnormal copper biochemistry, such as tumor angiogenesis, liver cirrhosis, hepatitis, pulmonary fibrosis and other fibrotic diseases, cardiovascular disease, cerebral ischemia, renal anemia, rheumatoid arthritis, diabetes, obesity, gastrointestinal disorders, and eye diseases such as glaucoma, proliferative diabetic retinopathy, and age related macular degeneration. These compounds have excellent stability and aqueous solubility for good oral bioavailability.

The invention discloses a method for measuring content of 11 illegally added medicaments in veterinary drug powder. The method comprises the following steps of (1) pre-treating veterinary drug powder to be measured by adopting an organic solvent ultrasonic extraction method, wherein an organic solvent is methanol-water, and a volume ratio of methanol to water is (0.9-1.1):(0.9-1.1); (2) detecting olaquindox, ribavirin, amantadine, rimantadine, dexamethasone, chloramphenicol, diethylstilbestrol, furaltodone, nitrofurantoin, nitrofural and furazolidone in extract by adopting liquid chromatography-tandem mass spectrometry. According to the method, a sample can be simply pre-treated by adopting methanol / water (50+50) as an extraction reagent for ultrasonic extraction, and can be loaded on a machine for detection after passing through a filter membrane, and a recovery rate is high; the method is lower in detection limit, a detection limit of the olaquindox, ribavirin, amantadine, rimantadine, dexamethasone, chloramphenicol, furaltodone and furazolidone is 50mu g / kg, and a detection limit of the nitrofurantoin, nitrofural and diethylstilbestrol is 100mu g / kg.

The present invention belongs to the field of chemically synthesized medicine and its preparation process. The medicine of the present invention is synthesized with amantadine, moroxydine, 5-Fu (5-Fc), isoniazid and other clinical medicine and polyoxometallate, and through self-assembling. The said polyoxometallate includes heteropoly acid salts of Keggin type with chemical expression XM12O40n-, Dowson type X2M18O62n- and of chemical expression LnW10O36n-. The combined use of said medicines and polyoxometallate has obvious curative effect on intractable streptococcus pneumoniae infection.

The invention discloses a specific molecularly imprinted polymer capable of recognizing amantadine and rimantadine, a chemiluminescent reagent kit using it as a recognition element, a detection method and an application. The molecularly imprinted polymer uses adamantane as a pseudomolecular template, and the synthesized specific molecularly imprinted polymer can simultaneously recognize amantadine and rimantadine. The chemiluminescence kit prepared based on the molecularly imprinted polymer can perform multi-residue detection of amantadine and rimantadine in meat tissue, and can be used repeatedly, thereby improving detection sensitivity, shortening detection time, and reducing detection cost.

The invention discloses a catechin-amantadine conjugate and its preparation method and application. The derivative structure: the preparation method is: selective protection of catechin; under alkaline conditions, synthesizing the protected catechin terminal alkyne body; synthesis of amantadine azide intermediate; click reaction between terminal alkyne precursor and azidoadamantane precursor to synthesize catechin-adamantane conjugate; deprotection synthesis of catechin-amantadine under hydrogenation catalyst couples. The synthetic catechin-amantadine conjugate has novel structure, simple synthesis route, no noble metal catalyst, and the synthesized catechin amantadine has good anti-influenza activity.

The invention discloses an anti-amantadine AMD single-chain antibody and its preparation and application. The present invention can obtain the heavy chain and light chain variable region genes of the antibody from the hybridoma cell line 3F2 secreting the monoclonal antibody of amantadine AMD through genetic engineering, and construct the prokaryotic expression plasmid by recombining the two genes The carrier is transformed into Escherichia coli to express the scFv antibody active fragment that can specifically recognize AMD. It is proved by experiments that the recombinant single-chain antibody scFv prepared by the present invention has specific recognition and binding activity with amantadine AMD. The amantadine residue detection can be realized by using the recognition and binding activity of the recombinant single-chain antibody of the present invention to amantadine, and the constructed transformation vector plasmid is easy to preserve and mass-produce.

The invention discloses a method for preparing vildagliptin by multiphase duplex continuous production. In the acid chloride solution, the reaction is carried out, the reaction solution is not treated, a dehydrating agent is added, quenched, the pH value is adjusted to neutrality, the organic layer is layered and added dropwise to the amantadine alcohol solution, the temperature is controlled and kept warm, concentrated, pulped, and filtered. , washing the filter cake, and drying to obtain vildagliptin. In the present invention, 2,6-lutidine is also used as a solvent as an acid binding agent, and the addition of amantadine is carried out under homogeneous conditions without generating solids, and the reaction solution is directly used to carry out the next step reaction. The stirring requirement is low; while the post-processing steps are reduced, the energy consumption is reduced and the yield is improved; the commercial production can be more realized; the time is shortened, the post-processing is simple, and the operating conditions are simple.

The invention discloses an aptamer specifically recognizing amantadine and its application. The nucleotide sequence of the aptamer specifically recognizing amantadine of the present invention is shown in SEQ ID NO.1. The present invention utilizes the systematic evolution technology of library immobilized exponentially enriched ligands, takes amantadine as the target, screens and obtains an aptamer sequence with high affinity and strong specificity for amantadine, and the screened aptamer sequence The ligand sequence is highly sensitive, easy to prepare and easy to modify, and will be applied to the rapid detection of amantadine veterinary drug residues in food.