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ICCB-containing compound preparation and preparation method thereof

A technology for cultivating bezoar and compound preparations in vitro, which is applied to medical preparations containing active ingredients, anti-inflammatory agents, anti-viral agents, etc. It can solve problems such as difficulty in uniformity, compliance with requirements, and low content, so as to avoid uneven dispersion , reduce vomiting, good dispersion effect

Inactive Publication Date: 2011-06-01
汤明昌 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] 2. The existing children's acetaminophen granules are made from in vitro cultured bezoar, acetaminophen, amantadine hydrochloride, chlorpheniramine maleate, and caffeine. Due to the large difference in the amount of therapeutic drugs and excipients , often lead to the uniformity of the drug does not meet the requirements, chlorpheniramine maleate, caffeine due to strong drug effect, the content is low, it is difficult to use conventional mixing, extrusion granulation to make the uniformity meet the requirements, often Some young children have symptoms of poisoning after taking the children's acetaminophen granules whose uniformity does not meet the requirements: such as coma, unresponsiveness, dry mouth and sore throat, overexcitement and other obvious side effects

Method used

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Embodiment Construction

[0023] Get 100g of paracetamol, 40g of amantadine hydrochloride, 4g of in vitro cultured bezoar, 6g of caffeine, 0.8g of chlorpheniramine maleate, auxiliary materials: 5800g of sucrose fine powder, 49.2g of edible sweet orange essence, and prepare according to the following method become:

[0024] Step 1: first take the in vitro cultured bezoar and grind it into fine powder for later use;

[0025] Step 2: Take chlorpheniramine maleate and add it to caffeine in equal increments, mix and grind evenly, pass through a 120-mesh sieve, and set aside;

[0026] Step 3: Take amantadine hydrochloride and add it to the powder obtained in the second step in an equal increasing method, grind it evenly, pass through a 120-mesh sieve, and set aside;

[0027] Step 4: Take the medicinal powder obtained in the third step and add it to the acetaminophen in an equal increment method, grind it evenly, pass through a 120-mesh sieve, and set aside;

[0028] Step 5: Take the fine powder of in vitro...

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PUM

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Abstract

The invention provides an ICCB-containing (in-vitro-cultured calculus boris) compound preparation which comprises the following components in parts by weight: 0.5 to 2 parts of ICCB, 20 to 30 parts of acetaminophen, 8 to 15 parts of amantadine hydrochloride, 0.1 to 0.4 parts of chlorpheniramine maleate, 1.0 to 2.5 parts of caffeine, and the appropriate amount of sucrose and food flavors auxiliary materials. By using the ICCB compound preparation instead of artificial bezoar, the side reactions in which vomit and jaundice symptoms are caused by over high free bilirubin contained in artificial boris can be reduced; medicament ingredients can be effectively dispersed with an equivalent increment method to mix and grind, thereby reducing side effects caused due to uneven contents of chlorpheniramine maleate, chlorpheniramine maleate and amantadine hydrochloride.

Description

technical field [0001] The invention relates to a compound preparation containing in vitro cultured bezoar and a preparation method thereof, belonging to the technical field of medicine production. Background technique [0002] The common cold and influenza in children are the most common childhood illnesses, which can cause symptoms such as fever, headache, sore limbs, sneezing, runny nose, nasal congestion, and sore throat. Many doctors or parents in our country often take children's paracetamol granules to sick children, which are made of artificial bezoar, acetaminophen, amantadine hydrochloride, caffeine, chlorpheniramine maleate plus sucrose and essence, but There are two problems in this product that have not been well resolved, the quality is not stable and the side reactions of this product often occur. One is that artificial bezoar is used in the prescription. Since the current standard does not limit the content of the harmful component free bilirubin, the probab...

Claims

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Application Information

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IPC IPC(8): A61K35/413A61P11/02A61P11/04A61P25/04A61P29/00A61P31/16A61K31/13A61K31/167A61K31/4402A61K31/522
Inventor 汤明昌
Owner 汤明昌
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