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Polyacid compound for resisting penicillin streptococcus pneumoniae (PRSP) and its preparing method

A technology of Streptococcus pneumoniae and polyacid compounds, which is applied in the field of chemical synthesis of drugs and their preparation, and can solve problems such as rising and loss of effectiveness of antibiotics.

Inactive Publication Date: 2005-05-18
NORTHEAST NORMAL UNIVERSITY
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  • Abstract
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Problems solved by technology

The rising incidence of Streptococcus pneumoniae resistance to penicillin (drug resistance mechanism is the change of penicillin-binding protein PBP2′), making many antibiotics gradually lose their original effectiveness

Method used

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Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0013] Synthesis Example 1

[0014] Amantadine and Keggin-type phosphomolybdic acid self-assembled compound [(C 10 h 18 N) 3 PMo 12 o 40 ·nH 2 O] the synthesis of: amantadine 100g is dissolved in 200ml water, dilute hydrochloric acid is acidified to pH about 6, is added dropwise under constant stirring condition to containing 402g (0.33moL) phosphomolybdic acid (H 3 PMo 12 o 40 ) in aqueous solution. With the addition of amantadine, the solution gradually became cloudy and finally produced a large amount of precipitate. Continue stirring for 1 h to make the reaction complete, separate the precipitate by suction filtration, wash twice with distilled water, then wash with ethanol, and dry in the air to obtain a yellow powder as (C 10 h 18 N) 3 PMo 12 o 40 ·nH 2 O. The yield was 85% based on amantadine.

[0015] Synthesis Example 2

[0016] Amantadine and Dowson-type arsenomolybdic acid self-assembly compound (C 10 h 18 N) 6 As 2 Mo 18 o 62 ·nH 2 O. Synth...

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Abstract

The present invention belongs to the field of chemically synthesized medicine and its preparation process. The medicine of the present invention is synthesized with amantadine, moroxydine, 5-Fu (5-Fc), isoniazid and other clinical medicine and polyoxometallate, and through self-assembling. The said polyoxometallate includes heteropoly acid salts of Keggin type with chemical expression XM12O40n-, Dowson type X2M18O62n- and of chemical expression LnW10O36n-. The combined use of said medicines and polyoxometallate has obvious curative effect on intractable streptococcus pneumoniae infection.

Description

technical field [0001] The invention belongs to chemically synthesized drugs and a preparation method thereof, in particular to polyacid antibacterial drugs capable of inhibiting penicillin-resistant Streptococcus pneumoniae (PRSP) and a preparation method thereof. Background technique [0002] Streptococcus pneumoniae belongs to Gram-positive bacteria and is one of the most important pathogens of severe invasive infections (such as meningitis, sepsis, acute otitis media, sepsis, pneumonia) and upper respiratory tract infections. Globally, 4 to 6 million people die each year from this bacterial infection. It was once considered that penicillin was a routine sensitive drug for Streptococcus pneumoniae. Since the first reports of penicillin-resistant Streptococcus pneumoniae (PRSP, penicilline-resistant streptococcuspneumoniae) infection in Australia and South Africa in the 1960s and 1970s, PRSP infection has There have been reports all over the world, and surveys have shown ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/28A61K31/555A61K31/66A61P31/04C07F3/00C07F11/00
Inventor 刘术侠白云鹏翟红菊杜宏明李德惠梁大栋
Owner NORTHEAST NORMAL UNIVERSITY
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