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A specific molecularly imprinted polymer of amantadine and rimantadine, a chemiluminescence kit, a detection method and application thereof

A chemiluminescent reagent, amantadine technology, applied in chemiluminescence/bioluminescence, analysis by making materials react chemically, measuring devices, etc., can solve the problem of molecularly imprinted polymers without amantadine and rimantadine Chemiluminescence and other issues

Active Publication Date: 2021-09-14
HEBEI AGRICULTURAL UNIV.
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there are no research reports on the synthesis of molecularly imprinted polymers for amantadine and rimantadine at home and abroad, nor have molecularly imprinted polymers been used as recognition elements to establish chemiluminescence methods, or to develop kits for amantadine and rimantadine. Research report on residue detection of rimantadine

Method used

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  • A specific molecularly imprinted polymer of amantadine and rimantadine, a chemiluminescence kit, a detection method and application thereof
  • A specific molecularly imprinted polymer of amantadine and rimantadine, a chemiluminescence kit, a detection method and application thereof
  • A specific molecularly imprinted polymer of amantadine and rimantadine, a chemiluminescence kit, a detection method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Molecularly imprinted polymer synthesis example 1

[0032] (a) Put 1 part of pseudomolecule adamantane, 3 parts of functional monomer methacrylic acid, 20 parts of initiator azobisisobutyronitrile and 20 parts of crosslinking agent ethylene glycol dimethacrylate in chloroform solvent In the reaction at 60°C for 12 hours, solid particles were obtained;

[0033] (b) Put the solid particles in a Soxhlet extractor, and continuously reflux the extraction solution of methanol and acetic acid (9:1, V / V) for 12 hours to extract the imprinted pseudomolecular template adamantane;

[0034] (c) drying the reacted solid particles in step (b) to obtain specific molecularly imprinted polymers of amantadine and rimantadine.

Embodiment 2

[0035] Example 2 Molecularly imprinted polymer synthesis example 2

[0036] (a) Put 1 part of pseudomolecular template adamantane, 6 parts of functional monomer methacrylic acid, 30 parts of initiator azobisisobutyronitrile and 30 parts of crosslinking agent ethylene glycol dimethacrylate in chloroform In a solvent, react at 70°C for 10 hours to obtain solid particles;

[0037] (b) Put the solid particles in a Soxhlet extractor, and continuously reflux the extraction solution of methanol and acetic acid (9:2, V / V) for 24 hours to extract the imprinted pseudomolecular template adamantane;

[0038] (c) drying the reacted solid particles in step (b) to obtain specific molecularly imprinted polymers of amantadine and rimantadine.

Embodiment 3

[0039] Example 3 Molecularly imprinted polymer synthesis example 3

[0040] (a) Put 1 part of pseudomolecular template adamantane, 4 parts of functional monomer methacrylic acid, 25 parts of initiator azobisisobutyronitrile and 25 parts of crosslinker ethylene glycol dimethacrylate in chloroform In the solvent, react at 65°C for 11 hours to obtain solid particles;

[0041] (b) Put the solid particles in a Soxhlet extractor, and continuously reflux the extraction solution of methanol and acetic acid (9:0.5, V / V) for 18 hours to extract the imprinted pseudomolecular template adamantane;

[0042] (c) drying the reacted solid particles in step (b) to obtain specific molecularly imprinted polymers of amantadine and rimantadine.

[0043] The scanning electron micrographs of the molecularly imprinted polymer prepared in this example are as follows: figure 2 shown by figure 2 It can be seen that its surface is porous, which is a cavity formed by molecular template imprinting, whi...

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Abstract

The invention discloses a specific molecularly imprinted polymer capable of recognizing amantadine and rimantadine, a chemiluminescent reagent kit using it as a recognition element, a detection method and an application. The molecularly imprinted polymer uses adamantane as a pseudomolecular template, and the synthesized specific molecularly imprinted polymer can simultaneously recognize amantadine and rimantadine. The chemiluminescence kit prepared based on the molecularly imprinted polymer can perform multi-residue detection of amantadine and rimantadine in meat tissue, and can be used repeatedly, thereby improving detection sensitivity, shortening detection time, and reducing detection cost.

Description

technical field [0001] The invention relates to the field of animal food safety, in particular to a molecularly imprinted polymer of amantadine and rimantadine, a chemiluminescence kit, a detection method and an application. Background technique [0002] Both amantadine and rimantadine belong to chemically synthesized antiviral drugs, which are widely used in the treatment of human influenza virus infection. Due to the lack of types of antiviral drugs at present, amantadine and rimantadine have also been widely used in the treatment of various viral infections in animals for a long period of time. However, their large-scale use can seriously induce drug resistance of various animal-derived viruses, and also lead to a decrease in the resources of antiviral drugs for human use. Therefore, the Ministry of Agriculture of China issued a notice in 2005 to prohibit the use of amantadine and rimantadine in the prevention and treatment of viral infectious diseases in food animals. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/76G01N30/02
CPCG01N21/76G01N30/02
Inventor 王建平张腾
Owner HEBEI AGRICULTURAL UNIV.
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