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Compound paracetamol and amantadine hydrochloride composition and preparation method thereof

A technology of compound acetaminophen and its composition, which is applied in the direction of drug combination, active ingredient of heterocyclic compound, pharmaceutical formula, etc., can solve the problem that seaweed polysaccharide has not been further developed, and achieve the effect of reducing the degree of liver damage

Inactive Publication Date: 2017-11-07
HARBIN ZHENBAO PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there has been no further development of other functions of seaweed polysaccharides

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A compound aminopheniramine composition, the formula is: 20g of chlorpheniramine maleate, 100g of artificial bezoar, 150g of caffeine, 1000g of amantadine hydrochloride, 2500g of paracetamol, and 3000g of seaweed polysaccharide.

[0027] Production process: material crushing→sieving→weighing→mixing→making soft material→extruding and rounding into pellets→drying→pelleting→total mixing.

[0028] Specific steps are as follows:

[0029] First crush all materials, sieve, weigh, mix chlorpheniramine maleate, artificial bezoar, and caffeine evenly, then add amantadine hydrochloride, acetaminophen, and seaweed polysaccharide to the above mixed powder and mix evenly , pulverize the obtained mixed powder and add wetting agent to make soft material, sieve and granulate, add the prepared granules to the coating granulator to make pellets, use purified water as wetting agent, and gradually add raw and auxiliary materials Roll the powder into pellets, dry at 45 degrees in a fluidize...

Embodiment 2

[0031] A compound aminopheniramine composition, the formula is: 20g of chlorpheniramine maleate, 100g of artificial bezoar, 150g of caffeine, 1000g of amantadine hydrochloride, 2500g of paracetamol, and 2400g of seaweed polysaccharide.

[0032] Production process: material crushing→sieving→weighing→mixing→making soft material→extruding and rounding into pellets→drying→pelleting→total mixing.

[0033] Specific steps are as follows:

[0034] First crush all materials, sieve, weigh, mix chlorpheniramine maleate, artificial bezoar, and caffeine evenly, then add amantadine hydrochloride, acetaminophen, and seaweed polysaccharide to the above mixed powder and mix evenly , pulverize the obtained mixed powder and add wetting agent to make soft material, sieve and granulate, add the prepared granules to the coating granulator to make pellets, use purified water as wetting agent, and gradually add raw and auxiliary materials Roll the powder into pellets, dry at 45 degrees in a fluidize...

Embodiment 3

[0036] A compound aminopheniramine composition, the formula is: 20g of chlorpheniramine maleate, 100g of artificial bezoar, 150g of caffeine, 1000g of amantadine hydrochloride, 2500g of paracetamol, and 3600g of seaweed polysaccharide.

[0037] Production process: material crushing→sieving→weighing→mixing→making soft material→extruding and rounding into pellets→drying→pelleting→total mixing.

[0038] Specific steps are as follows:

[0039] First crush all materials, sieve, weigh, mix chlorpheniramine maleate, artificial bezoar, and caffeine evenly, then add amantadine hydrochloride, acetaminophen, and seaweed polysaccharide to the above mixed powder and mix evenly , pulverize the obtained mixed powder and add wetting agent to make soft material, sieve and granulate, add the prepared granules to the coating granulator to make pellets, use purified water as wetting agent, and gradually add raw and auxiliary materials Roll the powder into pellets, dry at 45 degrees in a fluidize...

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PUM

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Abstract

The invention relates to a compound paracetamol and amantadine hydrochloride composition, which comprises, by weight, 200-300 parts of paracetamol, 80-120 parts of amantadine hydrochloride, 12-18 parts of caffeine, 8-12 parts of artificial bezoar, 1-3 parts of chlorpheniramine maleate, and 200-400 parts of seaweed polysaccharide. According to the present invention, the component ratio is adjusted on the basis of the pharmaceutical components of the conventional paracetamol and amantadine hydrochloride composition, and the specific proportion of the seaweed polysaccharide is added, such that the obtained composition can provide good protection effect on the immune liver injury caused by acetaminophen, and can reduce the degree of liver injury caused by paracetamol.

Description

technical field [0001] The invention relates to a compound aminopheniramine composition and a preparation method thereof, belonging to the technical field of medicine preparation. Background technique [0002] Drug-induced liver injury refers to liver damage caused by the drug itself or its metabolites after the use of one or several drugs. It is reported that more than 1,100 drugs have potential hepatotoxicity among the compound or biological drugs that have been applied on the market; the excipients of many drugs, Chinese herbal medicines and health care drugs also have the possibility of causing liver damage. Drug-induced liver injury can manifest as any type of acute or chronic liver disease known so far, among which acute liver injury is the most common, accounting for more than 90% of the reported cases, and life-threatening fulminant or severe liver function may occur in a small number of patients Failure is the focus of clinical monitoring and prevention of drug hep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/413A61K9/48A61P11/00A61K31/4402A61K31/522A61K31/13A61K31/167A61K31/715A61K36/02
CPCA61K9/1605A61K31/13A61K31/167A61K31/4402A61K31/522A61K31/715A61K35/413A61K36/02A61K2300/00
Inventor 方同华许照芹崔玉海岳大彪
Owner HARBIN ZHENBAO PHARMA
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