A method for determining the content of 11 kinds of illegally added drugs in Chinese veterinary medicine powder
A technology for illegally adding and veterinary drugs, applied in measuring devices, instruments, scientific instruments, etc., can solve the problems of low sensitivity, poor accuracy, complicated operation, etc., and achieve the effect of simple pretreatment and good recovery rate
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Embodiment 1
[0046] 1. Optimization of chromatographic conditions
[0047] In this study, a 2.1×150mm, 5μm C18 chromatographic column was selected to ensure the effective separation of 11 illegally added drugs in a relatively short period of time. The experiment compares the influence of methanol-water and acetonitrile-water system as the mobile phase on the separation effect of 11 illegally added drugs. The results show that the selectivity of the test compound in the acetonitrile-water mobile phase is better than that of methanol-water system and due to the The polarity difference is large, and the experiment adopts the gradient elution method to obtain the ideal chromatographic separation effect, and the single operation time is only 10min.
[0048] 2. Optimization of mass spectrometry conditions
[0049] Table 1 Optimized mass spectrometry conditions for 11 illegally added drugs (the ones with * are quantified ions)
[0050]
[0051] Using the flow injection method, each compound ...
Embodiment 2
[0063] Actual sample analysis
[0064] Pulsatilla powder, Zhili powder, Qingwenbaidu powder, Yinqiao powder, Chuanxinlian powder, Huanglian Jiedu powder, Fuzheng Jiedu powder, Xiaoshi Pingwei powder, Jingfang Baidu powder, Gongying powder, Qingfeizhike powder, Wupi powder San, Qibu San, Sangju San and other 35 commercially available Chinese veterinary medicine powders were detected by HPLC-MS / MS (see the total ion chromatogram of the samples in Figure 12 and Figure 13 As shown), the test results showed that none of the 11 types of illegally added drugs were detected in the veterinary medicine powder to be tested.
[0065] in conclusion
[0066] In this paper, high performance liquid chromatography tandem mass spectrometry was used to establish an analytical method for 11 illegally added drugs in Chinese veterinary medicine powder. The method is simple, fast, sensitive, specific, and reproducible. It can simultaneously determine 11 illegally added drugs, realizing its high...
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