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Method for preparing compound paracetamol and amantadine hydrochloride pills

A compound paracetamol pill and a technology for compound paracetamol are applied to a device for preparing compound paracetamol and the field of preparation thereof, and can solve the problems of undisclosed coating granulator structure, mixing equipment disclosure and the like, Achieve product quality assurance, solve inefficiencies, and ensure product quality.

Pending Publication Date: 2021-08-20
浙江亚峰药厂有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this patent does not propose an effective solution to the problem of uniform mixing of acetaminophen, amantadine hydrochloride and artificial bezoar, nor discloses the mixing equipment to be used, nor discloses the structure of a suitable coating granulator
[0006] The inventor's in-depth and extensive research has found that the process of preparing compound acetaminophen pellets from amantadine hydrochloride, acetaminophen, chlorpheniramine maleate, artificial bezoar and caffeine is uniformly mixed and automated. There are two problems in production, and the problem of uniform mixing involves three problems of mixing equipment, process flow and process parameters to be solved

Method used

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  • Method for preparing compound paracetamol and amantadine hydrochloride pills
  • Method for preparing compound paracetamol and amantadine hydrochloride pills
  • Method for preparing compound paracetamol and amantadine hydrochloride pills

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Embodiment 1

[0051] A device for preparing compound amphetamine pills provided by the present invention comprises a grade A mixing unit, a grade B mixing unit, a grade C mixing unit, a D granulation unit and a control unit.

[0052] The control unit includes a time control unit, a temperature control unit, a flow control unit, a particle size control unit and a pressure control unit connected to each mixing subunit.

[0053] The outlet of the A-level mixing unit is connected with the feed inlet and the third coating section of the D granulation unit respectively through a tee; wherein, the mixture sent into the feed inlet is the core pellet mixed with water, and the core pellets are prepared. The pellets are prior art, and the present invention is not shown; the feeding material connected with the third coating section of the D granulation unit is the coating material mixed with water.

[0054] The outlet of the B-level mixing unit is respectively connected to the inlet of the C-level mixi...

Embodiment 2

[0074] A preparation process for preparing compound acetaminophen pills. Compound acetaminophen pills are prepared from chlorpheniramine maleate, artificial bezoar, caffeine, amantadine hydrochloride, acetaminophen and dextrin in parts by weight The compound acetaminophen pills comprise a pellet core prepared in sequence, an intermediate layer sprayed twice and an outer layer sprayed.

[0075] Attached below figure 1 and Figure 4A The preparation process for the preparation of compound amphetamine pills provided by the present invention is described in detail, unless otherwise specified, the parts of each material in the present invention are in parts by mass:

[0076] (1) Preparation of core pills: respectively, paracetamol 125, amantadine hydrochloride 50, and artificial bezoar 50 Figure 1A Supported by the support frame shown, premixed by a feeding screw, a motor, and a premixing port with a rotary rotor, it is sent into the mixing unit A through the discharge port and ...

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PUM

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Abstract

The invention provides a method for preparing compound paracetamol and amantadine hydrochloride pills. The compound paracetamol and amantadine hydrochloride pills are prepared from chlorpheniramine maleate, calculus bovis factitius, caffeine, amantadine hydrochloride, paracetamol and dextrin in parts by mass. The compound paracetamol and amantadine hydrochloride pills comprise core pills, a spraying layer and an outer layer which are prepared in sequence. The process comprises the following steps: respectively connecting the outlet side of an A-grade mixing unit with a feeding hole and a third coating section of a granulation unit D through a tee joint with a valve. According to the technical scheme provided by the invention, the defects that the mixing units are uneven in mixing and the components are not uniformly distributed in a standby state in the preparation process are overcome, unified coordination management among various production steps is lacked, and the production efficiency is greatly improved.

Description

technical field [0001] The invention relates to a pill manufacturing process, in particular to a device for preparing compound amphetamine pills and a preparation method thereof. Background technique [0002] The invention relates to a compound phenalkamine capsule, which belongs to a compound capsule preparation, and its main components are amantadine hydrochloride, acetaminophen, chlorpheniramine maleate, artificial bezoar and caffeine. It is used for nasal congestion, runny nose, sneezing, sore throat, headache, fever, etc. caused by colds, and can also be used for the prevention and treatment of influenza. [0003] "The Chinese invention patent application with the publication number CN1742751A discloses a compound aminophenamine dripping pill and a preparation method thereof. The method is to mix acetaminophen, amantadine hydrochloride, artificial bezoar, caffeine, Chlorpheniramine is mixed with the dripping pill base, heated to melt, stirred evenly, dripped with a coo...

Claims

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Application Information

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IPC IPC(8): A61K9/28A61K35/413A61K47/36B01F13/10A61J3/06A61P11/00A61P31/16A61P29/00A61P11/02A61P11/04A61P25/00A61K31/13A61K31/167A61K31/4402A61K31/522
CPCA61K31/4402A61K35/413A61K31/522A61K31/13A61K31/167A61K9/2886A61K9/2059A61P11/00A61P31/16A61P29/00A61P11/02A61P11/04A61P25/00A61J3/06B01F33/813A61K2300/00
Inventor 蒋绍俊江伟根陆康康喻淑丹陈婷金钱露蒋宇佳商铁存
Owner 浙江亚峰药厂有限公司
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