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A kind of graphene oxide intelligent drug carrier that can be sensitively shed by supramolecules and its preparation method and application

A graphene and supramolecular technology, applied in the field of preparation of nano-carriers, can solve the problems of hindering the rapid release of drugs, inability to be sensitive to shedding, etc., and achieve the effects of improving drug release rate and drug loading rate.

Inactive Publication Date: 2017-05-10
NORTHWEST UNIV(CN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, very few documents have reported the possibility of supramolecularly modified graphene oxide being used as a drug carrier, and the reported supramolecularly modified graphene oxide cannot be sensitively detached, which hinders the rapid release of drugs (H.Dong, Y.Li, J.Yu , Y.Song, X.Cai, J.Liu, J.zhang, R.C.Ewing, D.Shi, Small, 2013, 9, 446-456.)

Method used

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  • A kind of graphene oxide intelligent drug carrier that can be sensitively shed by supramolecules and its preparation method and application
  • A kind of graphene oxide intelligent drug carrier that can be sensitively shed by supramolecules and its preparation method and application
  • A kind of graphene oxide intelligent drug carrier that can be sensitively shed by supramolecules and its preparation method and application

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Experimental program
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Embodiment 1

[0049] see figure 1 , a kind of preparation method of the graphene oxide smart drug carrier that supramolecule can be sensitive to come off, comprises the following steps:

[0050] (1) Carboxylation of polyethylene glycol

[0051] Polyethylene glycol (PEG, Mw=2000, 99% purity, 2.0 mmol) was placed in a round bottom flask, and then 30 mL of dimethyl sulfoxide was added to the round bottom flask to dissolve the polyethylene glycol. Add 10 mL of 40% NaOH solution and 20 mmol of chloroacetic acid. After stirring and reacting at room temperature for 10 h, the solvent was distilled off under reduced pressure, and then 100 mL of anhydrous dichloromethane was added thereto. Filtration to remove salt, rotary evaporation to concentrate the filtrate to obtain a concentrated solution, the concentrated solution was added to cold ether, precipitation occurred, and a white solid was obtained by suction filtration, and the obtained white solid was vacuum-dried at 30°C to obtain carboxylatio...

Embodiment 2

[0064] A kind of preparation method of the graphene oxide intelligent drug carrier that supramolecule can fall off sensitively, comprises the following steps:

[0065] (1) Carboxylation of polyethylene glycol

[0066] Polyethylene glycol (PEG, Mw=2000, 99% purity, 2.0 mmol) was placed in a round bottom flask, and then 25 mL of dimethyl sulfoxide was added to the round bottom flask to dissolve the polyethylene glycol. Add 15 mL of 40% KOH solution and 20 mmol of chloroacetic acid. After stirring the reaction at room temperature for 12 h, the solvent was distilled off under reduced pressure, and then 150 mL of anhydrous dichloromethane was added thereto. Filtration to remove salt, rotary evaporation to concentrate the filtrate to obtain a concentrated solution, the concentrated solution was added to cold ether, precipitation occurred, and a white solid was obtained by suction filtration, and the obtained white solid was vacuum-dried at 30°C to obtain carboxylation Polyethylene...

Embodiment 3

[0080] A kind of preparation method of the graphene oxide intelligent drug carrier that supramolecule can fall off sensitively, comprises the following steps:

[0081] (1) Carboxylation of polyethylene glycol

[0082] Polyethylene glycol (PEG, Mw=2000, 99% purity, 2.0 mmol) was placed in a round bottom flask, and then 35 mL of dimethyl sulfoxide was added to the round bottom flask to dissolve the polyethylene glycol. Add 10 mL of 40% NaOH solution and 20 mmol of chloroacetic acid. After stirring the reaction at room temperature for 15 h, the solvent was distilled off under reduced pressure, and then 120 mL of anhydrous dichloromethane was added thereto. Filtration to remove salt, rotary evaporation to concentrate the filtrate to obtain a concentrated solution, the concentrated solution was added to cold ether, precipitation occurred, and a white solid was obtained by suction filtration, and the obtained white solid was vacuum-dried at 30°C to obtain carboxylation Polyethylen...

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Abstract

A supramolecular sensitive exfoliated graphene oxide smart drug carrier and its preparation method and application. Dissolve carboxylated amantadine in methylene chloride, then add EDC and NHS, and stir to obtain a solution; dissolve cystamine in In dichloromethane, add it to the solution to obtain amantadine containing disulfide bonds. Dissolve EDC in water, then add it to the GO‑COOH suspension. After sonication, add NH2‑SS‑PEG‑Ad and stir. After dialysis, amantadine-modified graphene oxide containing disulfide bonds was obtained; NGO‑SS‑Ad and cyclodextrin suspension were mixed and shaken to obtain cyclodextrin-modified graphene oxide. The supramolecular functionalized graphene oxide core-shell nano drug carrier synthesized by the present invention carries hydrophobic drugs containing large π conjugated structures through π-π interactions and hydrophobic interactions, and the disulfide bonds can be rapidly cleavable in the intratumor cell environment. , to realize the functions of supramolecular shedding and intelligent drug release.

Description

technical field [0001] The invention relates to a preparation method of a nano-carrier, in particular to a graphene oxide smart drug carrier capable of sensitive shedding of supramolecules, a preparation method and an application thereof. Background technique [0002] Nanographene oxide (NGO) is an inexpensive nanomaterial with a unique two-dimensional nanostructure and abundant oxygen-containing functional groups, which can be used to load water-soluble or insoluble drugs through non-covalent interactions for drug delivery system research , and its loading rate far exceeds that of other nanomaterials, up to 200%. Therefore, the research based on graphene oxide drug carrier has attracted the attention of many researchers (Z.Liu, J.T.Robinson, X.M.Sun, H.J.Dai, J.Am.Chem.Soc.2008,130,10876; L.M.Zhang, Z.X.Lu , Q.H.Zhao, J.Huang, H.Shen, Z.J.Zhang, Small 2011, 7, 460.). [0003] However, when the dispersion medium is a physiological solution, such as phosphate buffered salin...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61P35/00C08B37/16A61K31/704
CPCA61K31/704C08B37/0015
Inventor 温惠云薛伟明郝芳芳刘星黄赛朋
Owner NORTHWEST UNIV(CN)
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