87results about How to "Strong binding" patented technology

The invention belongs to the field of medical clinical immediate tests, and relates to a colloidal gold test strip for a double-amplification system and a preparation method thereof. The colloidal gold test strip for the double-amplification system comprises a test strip bottom lining, and a sample pad, a polyester film coated with a gold-labeled antibody, a coating film and absorbent paper whichare lapped with and adhered to the test strip bottom lining in turn, wherein the middle part of the coating film is parallelly provided with a detection line coated with streptavidin and an F(ab)2 fragment of a monoclonal antibody of an antigen to be detected, and a control line coated with a rabbit anti-rat immunoglobulin G (IgG) antibody; the F(ab)2 fragment of the monoclonal antibody of the antigen to be detected and biotin are coated in the sample pad; and the gold-labeled antibody is colloidal gold labeled protein A and the monoclonal antibody of the antigen to be detected. The test strip has the advantages of high specificity, sensitivity and detection speed, has low cost, is easy to operate, can be widely applied to the detection of the antigen to be detected, and lays a foundationfor the timely discovery and prediction and effective detection of diseases, and an instrument and equipment are not required to be used.

The invention relates to a method of selection, by two-dimensional separation, of nucleic acids that bind to a target molecule with high affinity from a mixture of nucleic acids, comprising the following steps: a) subjecting the mixture of nucleic acids to a physico-chemical separation step, thereby obtaining a set of mixed fractions containing the nucleic acids, a run parameter window being associated with every mixed fraction containing the nucleic acids, b) contacting a mixed fraction containing the nucleic acids with the target molecule, thereby obtaining a binding mixture containing nucleic acid / target molecule complexes, c) subjecting the binding mixture from step b) to the same physico-chemical separation step as in step a), thereby selecting nucleic acid / target molecule complexes whose run parameters are outside of the run parameter window.

The invention relates to a traditional Chinese medicine clinical digital evaluation system.The system includes five first-grade indexes including a clinical treatment effect index, a preponderant disease index, a traditional Chinese medicine diagnosis and treatment method index, a work attitude index and a workload index.The ability of a doctor can be graded and analyzed through the big data analysis technology on the basis of the traditional Chinese medicine clinical digital evaluation system.Evaluation is conducted layer upon layer from sub-index evaluation to comprehensive evaluation, internal evaluation and external evaluation are organically combined, and clinical treatment effects, preponderant disease categories, traditional Chinese medicine diagnosis and treatment methods and work efficiency and work attitude of doctors are comprehensively analyzed.By means of the big data processing technology, the indexes are subjected to detailed weight calculation to obtain a data conclusion with bases, and accordingly work ability and level of traditional Chinese medicine doctors are scientifically evaluated.

The invention discloses an anti-pollution separation membrane and a preparation method, wherein aiming at the shortages of a preparation technology for the present anti-pollution PVDF (polyvinylidene fluoride) separation membrane, the invention provides a novel method for preparing an anti-microbial pollution PVDF separation membrane. The novel method provided by the invention comprises the following steps of: synthesising the random copolymer with a zwitterionic structure, of MMA (methl methacrylate), DMC (dimethyl carbonate) and AMPS (2-acrylamido-2-methylpropane sulfonic acid) via free radical polymerization at first, adding the copolymer and a porogenic agent, i.e., polyethylene glycol (PEG) in PVDF, and preparing the anti-pollution separation membrane by using N,N-dimethyl formamide (DMF) as a solvent and using water as a coagulating agent through a phase inversion method. Electropositive quaternary amine group and electronegative sulfonic group exist in the structure of the copolymer simultaneously, and have a binding capacity for water molecules which is much stronger than the binding capacity of traditional polyethylene glycol and the derivatives of the traditional polyethylene glycol, and the formed hydration layer is more stable; therefore, the prepared novel PVDF membrane is lasting in anti-pollution performance.

The invention relates to a method for preparing a gel injection mold of a gradient material in a revolving magnetic field. The existing method is difficult to realize continuous and even variation of material compositions, or difficult to obtain large-thickness materials and the like. The method comprises the following steps: mixing ferromagnetic particles and non-magnetic particles into mixed powder; preparing organic monomer and a cross-linking agent into premixed solution; adding the mixed powder into the premixed solution; adding a dispersing agent into the solution; obtaining a dispersedslurry through ball milling and ultrasonic dispersion treatment; adding an initiator and a catalyst into the dispersed size; pouring the size into a mold after stirring; applying the revolving magnetic field outside the mold; and taking out the mold after gelling, drying, pressing and sintering. The method can prepare gradient materials with various thicknesses in a large ingredient range, has continuous variable and controllable ingredients, simplified process and reduced cost.

Conjugates of specific PBD dimers with an antibody that that binds to CD19, the antibody comprising a VH domain having the sequence according to any one of SEQ ID NOs. 1, 2, 3, 4, 5 or 6, optionally further comprising a VL domain having the sequence according to any one of SEQ ID NOs. 7, 8, 9, 10, 11 or 12.

The invention discloses a high-speed translational movement parallel mechanism with three degrees of freedom. The high-speed translational movement parallel mechanism comprises a fixed platform, a moving platform and three moving branched chains with identical structures; the three moving branched chains are connected between the fixed platform and the moving platform in parallel, each moving branched chain comprises a driving arm and a composite secondary branched chain with two degrees of freedom, and each composite secondary branched chain with the two degrees of freedom can translate in three-dimensional space; and the fixed platform is connected with the driving arms by rotation pairs, lower ends of the composite secondary branched chains are directly fixed to the moving platform, and the driving arms are connected with the composite secondary branched chains by rotation pairs or hooke joints. The high-speed translational movement parallel mechanism with the three degrees of freedom has the advantages that the moving branched chains comprise the composite secondary branched chains, so that independent secondary assemblies can be formed, and the high-speed transitional movement parallel mechanism is high in moving platform gesture restraining capacity and is favorable for high-speed movement; and a spatial polyhedron can be formed on the moving platform by centers of tail-end hinges of the moving branched chains of the mechanism, so that the mechanism is high in lateral load resistance.

The invention discloses an electrically controlled micronano optical fiber optical switch based on a graphene thin film. The electrically controlled micronano optical fiber optical switch comprises a tapering light output micronano optical fiber, a tapering light input micronano optical fiber and a circuit control module based on the graphene thin film, wherein in the circuit control module based on the graphene thin film, a silicon base coated with the graphene thin film is used as a center; a metal electrode is arranged on the rim of the silicon base; the tapering light output micronano optical fiber and the tapering light input micronano optical fiber are oppositely arranged on the graphene silicon base; the ends of the two micronano optical fibers are adsorbed together by a van der Waals force, and serve as a coupling end of a light path; and ultraviolet photoresist with low refractive index is coated on the micronano optical fibers. On the basis of the property of graphene, the novel optical fiber optical switch has the characteristics of small size, short response time, low driving voltage and improved reliability by combining the evanescent wave characteristics of the micronano optical fibers.

A cutting insert has an approximately polygonal plate shape with a cutting edge formed on a intersection portion between a rake face and a flank. A chip breaker is formed on the rake face, and a chip-breaker concave portion is defined by an inclined surface which is curved in a concave manner and which is smoothly connected to the bottom surface portion while being gradually inclined toward the bottom surface portion, from a peripheral edge portion on a nose portion side to a bottom surface portion.

The invention relates to a tunnel excavation three-dimensional model experiment loading device. The device comprises a loading frame, a front baffle, a rear baffle and self-balancing reaction frames, wherein the loading frame comprises frame columns, a moving cross beam and an upper cross beam; a plurality of lateral hydraulic cylinders are symmetrically installed on the inner sides of the frame columns; a plurality of vertical hydraulic cylinders are installed at the bottom of the moving cross beam; a lifting device is installed on the upper cross beam; the front baffle comprises a transparent organic glass baffle and a steel channel baffle; a hole is cut in the organic glass baffle; the organic glass baffle is arranged on the inner side of the steel channel baffle; more than one self-balancing reaction frame is arranged outside each of the front and rear baffles respectively; a plurality of jacks are arranged between the self-balancing reaction frames and the front baffle; and jack base plates are arranged on the front baffle. The device can generate various rock and soil mass three-dimensional stress fields with different burial depths and geological conditions and can achieve the chamber excavation model experiments under complicated conditions, such as different clear distances, different sections, and the like under high and low unsymmetrical pressure conditions.

The invention discloses a method for synchronously achieving incineration fly ash detoxification and chromium slag reduction curing. The method includes the following steps that (1), incineration flyash and tuff are weighed, mixed to be uniform and ground, and gelatinized powder is obtained; (2), sodium hydroxide and sodium silicate are weighed, mixed to be uniform and ground, and an alkali activator is obtained; (3), sodium persulfate and sodium oxalate are weighed, mixed to be uniform and ground, and a reductive detoxification inducer is obtained; (4), chromium slag, the gelatinized powder,the alkali activator and the reductive detoxification inducer are weighed, mixed to be uniform and ground, and fly ash and chromium slag powder is obtained; (5), the fly ash and chromium slag powderis weighed and dissolved in water, the materials are mixed to be uniform, and fly ash and chromium slag slurry is obtained; (6), the fly ash and chromium slag slurry is sealed, activated through microwaves, cooled and put in a die to be cured. The leaching concentrations of multiple heavy metals and dioxin in the fly ash and a chromium heavy metal in the chromium slag are all lower than the entrance limiting value of a municipal solid waste landfill. Treated cured bodies have high acid resistance and high constraint capacity for heavy metal inorganic pollutants and organic pollutants.

The invention relates to a preparation method of a superhydrophilic anti-pollution PVDF (polyvinylidene fluoride) separation membrane. An alkaline solution is used to treat PVDF surface to generate double bonds; hyperbranched polyethyleneimine is crosslinked on the PVDF membrane surface via chemical bonds by means of amino-vinyl additive reaction and amino-epoxy ring-opening reaction; the hyperbranched polyethyleneimine on the membrane surface are subjected to amino-epoxy ring-opening reaction with glycidol to obtain the anti-pollution PVDF membrane. The modified PVDF membrane has massive amino groups, hydroxyl radicals and other active groups, so that the membrane surface hydrophilicity is greatly improved. The problem with high hydrophobicity of the PVDF membrane itself is solved; it isavoided that pollutants easily adsorb or deposit on membrane surface or in membrane pores during application; anti-pollution capacity of the membrane is improved; the service life of the membrane is extended. Modifying is carried out herein by chemical processes, the conditions are mild, operating is simple, expensive instruments are not required, and the preparation method is easy to popularize,the product is firm, has good anti-pollution performance and has potential great application value in the water treatment field.

The invention discloses a water-based soy protein-based supramolecular sulfur positive electrode binder and a preparation method and application thereof. The binder is prepared from phosphorylated soybean protein, a lithium ion transmission promoter and a physical cross-linking agent through a physical blending method. The binder has a three-dimensional network cross-linked structure and the characteristics of the raw materials so that the binder has excellent mechanical properties, high ionic conductivity, strong lithium polysulfide adsorption capacity and certain biodegradability. When the binder is applied to the lithium-sulfur battery, the cycle life, the rate capability and the specific capacity of the battery can be effectively improved. A physical blending preparation method is used, a phosphorylated soybean protein aqueous solution, a lithium ion accelerant aqueous solution and a physical cross-linking agent aqueous solution are directly mixed to obtain the binder which is cross-linked by intermolecular hydrogen bonds and has a three-dimensional network structure, the process conditions are simple, efficient and convenient, and no pollution is caused to the environment whenwater is used as a solvent.

The invention provides a whole-cycle ambiguity single epoch determining method for a Beidou system reference station, which belongs to the technical field of satellite positioning systems and positioning measurement. According to the whole-cycle ambiguity single epoch determining method, the phase of a whole-constellation three-frequency carrier is sufficiently utilized for observing data. The method comprises the steps of establishing an integer linear relationship between the phase whole-cycle ambiguities of carriers B2 and B3 in which a satellite orbit error and a troposphere error are eliminated; establishing an equal-proportion integer linear relationship between the phase whole-cycle ambiguities of the carriers B2 and B3; performing single epoch determination for the phase whole-cycle ambiguities of the carriers B2 and B3; and through the integer linear relationship between the phase whole-cycle ambiguities of the three-frequency carriers of a Beidou system, realizing single epoch determination for the whole-cycle ambiguity of the phase observed value of the three-frequency carriers of a Beidou system reference station. According to the whole-cycle ambiguity single epoch determining method, whole-cycle ambiguity determination is performed on a single double-difference satellite; resolving for a Beidou system reference station net carrier phase observation equation set is not required, and calculation amount in determining the ambiguity is reduced.

A functionalized active-nucleus complex sensor that selectively associates with one or more target species, and a method for assaying and screening for one or a plurality of target species utilizing one or a plurality of functionalized active-nucleus complexes with at least two of the functionalized active-nucleus complexes having an attraction affinity to different corresponding target species. The functionalized active-nucleus complex has an active-nucleus and a targeting carrier. The method involves functionalizing an active-nucleus, for each functionalized active-nucleus complex, by incorporating the active-nucleus into a macromolucular or molecular complex that is capable of binding one of the target species and then bringing the macromolecular or molecular complexes into contact with the target species and detecting the occurrence of or change in a nuclear magnetic resonance signal from each of the active-nuclei in each of the functionalized active-nucleus complexes.

The invention relates to a multi-cavity concrete filled steel tubular column with a reinforcement cage and an implementation method of the multi-cavity concrete filled steel tubular column, belonging to the energy dissipation and seismic mitigation control field in an architectural structure. The multi-cavity concrete filled steel tubular column with the reinforcement cage comprises a polygonal steel tube, an integrated inner clapboard, an inner clapboard, concrete and the reinforcement cage. Compared with the prior art, the polygonal concrete filled steel tubular column is internally provided with the integrated inner clapboard and the inner clapboard for dividing a large cavity into multiple small cavities, the core concrete constraining ability is improved, the primary lateral rigidity, the bearing force and the drawability of components are improved, the reinforcement cage is arranged in the cavity of the polygonal concrete filled steel tubular column and is matched with a multi-cavity steel tube to achieve combined restraining effect on the concrete and improve the compressive capacity and the drawability of the components.

The invention discloses a large section inclined tunnel type arc seat structure for an arch bridge and a construction method thereof. The large section inclined tunnel type arc seat structure comprises an arc seat body, the arc seat body comprises a tunnel chamber dug on the subgrade surface in the inclined direction and a backfill layer arranged in the tunnel chamber, the tunnel chamber comprisesa tunnel body section and a tunnel opening section, the tunnel body section and the tunnel opening section are arranged in the longitudinal direction, the tunnel body section is of a single-layer lining structure, the tunnel opening section is of a double-layer lining structure, and a tunnel opening protective shed is arranged on the outer wall of the tunnel opening section. According to the large section inclined tunnel type arc seat structure for the arch bridge and the construction method thereof, large excavation and high slope of the arc set foundation are avoided, construction risks andpotential operational risks in the construction process are lowered, and meanwhile environmental protective quality is improved.

The invention discloses an anti-pollution separation membrane and a preparation method, wherein aiming at the shortages of a preparation technology for the present anti-pollution PVDF (polyvinylidene fluoride) separation membrane, the invention provides a novel method for preparing an anti-microbial pollution PVDF separation membrane. The novel method provided by the invention comprises the following steps of: synthesising the random copolymer with a zwitterionic structure, of MMA (methl methacrylate), DMC (dimethyl carbonate) and AMPS (2-acrylamido-2-methylpropane sulfonic acid) via free radical polymerization at first, adding the copolymer and a porogenic agent, i.e., polyethylene glycol (PEG) in PVDF, and preparing the anti-pollution separation membrane by using N,N-dimethyl formamide (DMF) as a solvent and using water as a coagulating agent through a phase inversion method. Electropositive quaternary amine group and electronegative sulfonic group exist in the structure of the copolymer simultaneously, and have a binding capacity for water molecules which is much stronger than the binding capacity of traditional polyethylene glycol and the derivatives of the traditional polyethylene glycol, and the formed hydration layer is more stable; therefore, the prepared novel PVDF membrane is lasting in anti-pollution performance.

The invention relates to an evolutionary password chip. The evolutionary password chip is manufactured by using the characteristic of infinite reconstruction of a programmable chip and the evolutionary design characteristic of intelligent calculation to dynamically design the algorithm of the key part of the password in real time. The password chip comprises the programmable chip and each part module of a DES algorithm arranged in the chip; each part module of the DES algorithm is connected with an intelligent calculation part; the intelligent calculation part comprises an adaptive value calculating module, an evolutionary operator module and a true random number generator which is connected with an evolutionary processing part by the evolutionary operator module. The algorithm of the key part of the password is realized by an intelligent calculation method.

The invention discloses a deep neural network-based scattering medium penetrating target positioning and reconstruction method, which is based on DINet and can be used for simultaneously predicting depth information and reconstructing a target image from a single speckle pattern. Image data of an experiment and a distance between an object and a scattering medium are collected by utilizing systemconfiguration; a speckle pattern statistical model system generated at different positions is configured to be used for collecting image data of an experiment and the distance between an object and ascattering medium; and the speckle pattern passes through the dual-channel network, generates a depth prediction value through the positioning channel network, and performs image restoration and reconstruction through the imaging channel network. According to the method, the multi-task challenge can be effectively solved, and multiple pieces of physical information can be obtained under the complex scattering condition. By utilizing a multi-task total loss function, the method has stronger constraint force on learning and training of the network, so that multi-task cooperative training has better performance in positioning tasks, and the positioning precision and the imaging quality are improved.

The present invention relation relates to a polarization retained type teraphertz wave fibre waveguide. It is characterized by that the cheap and pliable polymer capillary tubes and capillary columns are axially and parallelly arranged to form fibre waveguide with tetragonal or rectangular checks, said structure has larger mode double refraction and stronger polarization retention, and can greatly reduce the transmission loss.

The invention provides a small divergence angle ridge-type laser device and manufacturing method therefor. The laser device comprises an epitaxial structure and a ridge waveguide structure formed on the epitaxial structure, wherein the ridge waveguide structure comprises a parallel gain region and a light field mode expanding region that are orderly arranged along a light emitting direction, width of the light field mode expanding region gradually increases along the light emitting direction, a narrow end of the light field mode expanding region is connected with the parallel gain region, width of the narrow end of the light field mode expanding region equals width of the parallel gain region, the parallel gain region is 100 to 300 um in length, and the light field mode expanding region is 10 to 150 um in length. According to the small divergence angle ridge-type laser device and the manufacturing method therefor, no adjustment of the epitaxial structure is needed, no new epitaxial technology or technology process is needed, increase of a threshold current can be controlled in a restrained way, output power of a semiconductor laser device cannot be limited, output power can be improved by more than 10%, and main parameter performance during utilization can be improved to a certain extent.

The embodiment of the invention provides a third-party application calling method and electronic equipment. The method comprises: loading a software development kit (SDK) by the electronic equipment; based on the SDK, calling content of an installation package of a third-party application by the electronic equipment, so as to realize services, provided by the third-party application, through the electronic equipment. By adopting the third-party application calling method and the electronic equipment, the technical problem of the electronic equipment in the prior art that the constraint force on the third-party application is relatively low is solved; the technical effects that the electronic equipment can effectively call the third-party application and has relatively strong constraint force on the third-party application are realized.

The invention provides a degradable polyamino acid derivative which has a molecular weight of 30,000-40,000Da. A series of primary, secondary and tertiary amino groups in a certain proportion are introduced to a side chain so that the degradable polyamino acid derivative has very strong pH buffering capability and higher capability of transferring and expressing a plasma DNA; and the DNA binding capability, the transfection efficiency and the cytotoxicity can be adjusted and optimized through adjusting the proportion of the primary, secondary and tertiary amino groups. The synthesizing steps are simple and easy to operate, and the safety is high; the structural frame of the degradable polyamino acid derivative is polyamino acid which has the advantages of degradability, low toxicity and the like, can be applied to preparation of a degradable polycation nano gene carrier material and has a structural formula as the specification.

In order to efficiently and sufficiently achieve an EA function by an EA mechanism when a seatbelt (3) is being withdrawn due to an inertia force from a vehicle occupant after a belt-retracting operation performed by a pretensioner (11) when the seatbelt (3) is being withdrawn due to an inertia force from a vehicle occupant after a belt-retracting operation by the pretensioner (11), a relative rotational torque is generated between a first spool component (4a) retracting the seatbelt (3) and a second spool component (4b) to which a driving force of the pretensioner (11) is transmitted. When the relative rotational torque reaches a predetermined value or more, a pin (31) is subject to bending deformation and tensile deformation so that the first spool component (4a) rotates relatively with respect to the second spool component (4b) in a belt-withdrawing direction. Accordingly, a spool (4) rotates in a belt-retracting direction so that a torsion bar (7) becomes twisted, whereby impact energy is absorbed.

The invention discloses a composite rubber film used for complex shape surface multi-pas laser shock reinforcement. The composite rubber film used for complex shape surface multi-pas laser shock reinforcement is composed of an energy absorbing layer and an energy restraint layer through connection; the energy absorbing layer and the energy restraint layer are arranged on a target material successively; the energy absorbing layer rubber film comprises two material layers, and is composed through connection of a black insulated rubber tape and a black double faced adhesive tape; the energy restraint layer is a transparent restraint layer, and is formed through blending of epoxy resin and a curing agent, and curing after adhesion onto the black double faced adhesive tape at half-cured state.A plurality of times of blast of a same point on the energy absorbing layer in a plurality of times of laser shock reinforcement is caused, and over gasification is avoided; a same point of the energyrestraint layer is capable of bearing a plurality of times of black without cracking; the composite rubber film is capable of bearing multi-pas laser shock reinforcement, reinforcement effect is improved, and laser shock reinforcement pre-treatment and post-treatment are simplified.

The invention discloses a method for an imaging geometric model based on a Pluecker straight line, and belongs to the field of surveying and mapping. The method comprises the following steps that a homonymous straight line is extracted from image space and object space; the image space is linearly and spirally moved to be linearly coplanar with the object space, and a coplanar condition equation is obtained; a Pluecker straight line imaging geometric model of a strong geometric condition can be built through the coplanar condition equation; an outer orientation element is calculated through the least square adjustment theory. The spiral movement of a space vector can be visually and clearly represented through the Pluecker straight line, the model is simple, and the geometric meaning is clear. Compared with a traditional method, the imaging geometric model based on the Pluecker straight line is higher in geometric locating precision and more stable in result.

The invention discloses a preparation method of amination graphene oxide reinforced fibers. The preparation method has the advantages that amination graphene oxide is evenly dispersed in nylon 6, a strong binding effect is achieved, and the performance of the modified fibers is enhanced.

The invention belongs to the field of an amorphous coating, in particular to a method for preparing nickel-base amorphous alloy coating. The method comprises the steps: first, mechanically ball-milling and drying molten allow powder which is prepared from, by mass, 2-5% of gadolinium element powder, 3-5% of niobium element powder, 5-15% of boron element powder, 12-15% of silicon element powder, 31-35% of iron element powder and 30-44% of Ni element powder; then, utilizing the synchronous powder feeding and laser cladding technology, entering into a molten metal bath under laser radiation under the protection of argon gas, and forming the nickel-base amorphous alloy cladding coating. The technological parameters of the laser cladding technology are as follows: the laser power is 12-14kW, the spot diameter is 1-4mm, the scanning speed is 7-10m / min, the flow of protection argon is 20-30L / min, and the powder feeding rate is 15-25g / min. the preparation method has the advantages of high efficiency, low energy consumption, controllable particle size and flexible component adjustment, and the formed amorphous coating has high hardness.