The invention discloses application of EMC10
protein as a biomarker in diagnosis of
male infertility. An experiment proves that by adopting substances capable of increasing EMC10
protein activity and / or expression quantity, the
male infertility can be prevented, the
male infertility can be treated, fertilisation of
sperm and eggs is promoted, fertilisation of
sperm and
zona pellucida-free eggs ispromoted, the mixing ability of the
sperm and a
cell membrane is improved, sperm dysfunction is treated, sperm maturation is promoted, maturation of the sperm in
epididymis is promoted, the motion ability of the sperm is improved, a
protein tyrosine phosphorylation level related with
capacitation of the sperm is improved, the
capacitation of the sperm is promoted, the
acrosome reaction ability ofthe sperm is improved, an abnormal form of the sperm is repaired, the activity of
sodium /
potassium-APT
enzyme is recovered, ionic balance in the sperm is maintained, Na<+> balance in the sperm is maintained, HCO3-balance in the sperm is maintained, the balance of a pH value in the sperm is maintained, and the
fertility of males is improved. The EMC10 protein disclosed by the invention has an important application value.