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Compound silkworm chrysalis bioactive small peptide composition

A technology of composition and silkworm chrysalis, which is applied in the direction of drug combination, effective ingredients of hydroxyl compounds, and pharmaceutical formulations, can solve problems such as difficulty in opening eyes, skin irritation, dependence, etc., and achieve strong spicy fragrance and remarkable effect , Improve the effect of thinking ability

Inactive Publication Date: 2016-01-13
ANHUI BIOLOGICAL PEPTIDE IND RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the existing refreshing drugs on the market mainly include central nervous system drugs, and there are many kinds of central nervous system excitatory drugs such as amphetamine and caffeine.
Most of them use a single influencing factor as a product development point, such as providing caffeine to stimulate people’s spirits. Most of these drugs have adverse reactions such as insomnia, anxiety, depression, headache, vomiting, palpitations, and tachycardia when used alone for a long time. The dosage is too large Dependence and withdrawal symptoms after discontinuation
Refreshing topical medicines represented by wind balm on the market are popular, but they have a strong irritation to the skin. The cooling effect breaks out instantly, then drops sharply and is difficult to last. It is even difficult to open the eyes after being used on the head and face. In view of this, such products can no longer meet the needs of modern people in pursuit of life taste.

Method used

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  • Compound silkworm chrysalis bioactive small peptide composition
  • Compound silkworm chrysalis bioactive small peptide composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Prescription: silkworm chrysalis small peptide 100g mint borneol total volatile oil 60g chrysanthemum total organic acid 50g

[0076] Ganoderma lucidum total polysaccharide 30g

[0077] Preparation method: Preparation of small peptides from silkworm chrysalis: take silkworm chrysalis, crush properly, add 10 times the amount of water to homogenate for 15 minutes, heat and boil for 15 minutes, let cool to room temperature, use hydrochloric acid to adjust the pH to 2.0±0.1, and then add 1% of the substrate Pepsin, hydrolyze at 40°C for 2 hours, then use sodium hydroxide solution to adjust the pH to 8±0.1, add trypsin with 1% substrate, and hydrolyze at 40°C for 4 hours, stir constantly and adjust the pH at Within the range of 8±0.1, after the enzymolysis is completed, continue to heat up and boil for 15 minutes, let it cool, centrifuge, collect the supernatant, adjust the pH to 7.0, add 2% activated carbon, stir evenly, filter, and the filtrate has a molecular weight cut-o...

Embodiment 2

[0083] Prescription: silkworm chrysalis small peptide 200g mint borneol total volatile oil 120g chrysanthemum total organic acid 100g

[0084] Ganoderma lucidum total polysaccharide 60g

[0085] Preparation method: Preparation of small peptides from silkworm chrysalis: take silkworm chrysalis, crush properly, add 10 times the amount of water to homogenate for 15 minutes, heat and boil for 15 minutes, let cool to room temperature, use hydrochloric acid to adjust the pH to 2.0±0.1, and then add 1% of the substrate Pepsin, hydrolyze at 40°C for 2 hours, then use sodium hydroxide solution to adjust the pH to 8±0.1, add trypsin with 1% substrate, and hydrolyze at 40°C for 4 hours, stir constantly and adjust the pH at Within the range of 8±0.1, after the enzymolysis is completed, continue to heat up and boil for 15 minutes, let it cool, centrifuge, collect the supernatant, adjust the pH to 7.0, add 2% activated carbon, stir evenly, filter, and the filtrate has a molecular weight cut...

Embodiment 3

[0091] Prescription: silkworm chrysalis small peptide 500g mint borneol total volatile oil 300g chrysanthemum total organic acid 250g

[0092] Ganoderma lucidum polysaccharides 150g

[0093] Preparation method: take silkworm chrysalis small peptide, mint borneol total volatile oil inclusion compound, chrysanthemum total organic acid, ganoderma lucidum total polysaccharide, mix well, add 240g starch and 35g magnesium stearate, use 90% ethanol as wetting agent to make granules, Compress and coat to obtain 5000 tablets, 0.3g±5% per tablet.

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Abstract

The invention discloses a silkworm chrysalis small peptide effective position composition with a refreshing effect, and belongs to the field of traditional Chinese medicines. The composition is composed of silkworm chrysalis small peptides extracted from silkworm chrysalis, mint and borneol total volatile oil extracted from mint and borneol, chrysanthemum total organic acids extracted from chrysanthemum flower and Mythic Fungus total polysaccharides extracted from Mythic Fungus according to a certain ratio, and pharmaceutical routine auxiliary materials are added to prepare various dosage forms. The composition can be clinically used to refresh and eliminate fatigue.

Description

technical field [0001] The present invention relates to a composition of active parts of traditional Chinese medicine with refreshing effect and a preparation method thereof, in particular to a composition of effective parts of traditional Chinese medicine extracted from silkworm chrysalis, mint, borneol, chrysanthemum and ganoderma lucidum, and a preparation method thereof, belonging to the field of traditional Chinese medicine . Background technique [0002] With the acceleration of the pace of life, people's life pressure is increasing day by day, and more and more people feel tension and fatigue, which can easily cause the human brain to be hypoxic, fatigued, and in a chaotic state. Most professional workers, such as white-collar workers, taxi drivers and scientific research workers, are in this sub-health state, which not only affects their health, but also reduces their work and study efficiency. According to surveys, the causes of office workers' fatigue and lack of ...

Claims

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Application Information

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IPC IPC(8): A61K38/01A61K35/64A61P25/00A61P39/00A61K36/534A61K31/045
Inventor 卢宁刘国飞
Owner ANHUI BIOLOGICAL PEPTIDE IND RES INST
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