The invention discloses a nickel-based alloy production and processing technology which comprises the steps of material preparation, material mixing, primary vacuum melting, secondary vacuum melting, curing, casting molding, heat treatment and surface treatment, and finally the finished nickel-based alloy is obtained. In the aspect of raw materials, the nickel-based alloy disclosed by the invention is prepared by weighing and using the following raw materials in percentage: 28.22 percent to 25.57 percent of Cr, 17.51 percent to 15.36 percent of Mo, 15.74 percent to 13.61 percent of Cu, 10.82 percent to 9.21 percent of Fe, 9.88 percent to 7.25 percent of Al, 6.56 percent to 4.76 percent of Si, 5.86 percent to 3.58 percent of Ni, 3.47 percent to 1.85 percent of W, 3.24 percent to 2.45 percent of Nb, 0.83 percent to 0.68 percent of Ti and 0.35 percent to 0.22 percent of In. W and In are added, W is matched with Cr and Ni, so that the wear resistance and corrosion resistance of the alloy can be improved, In is high in plasticity and good in ductility, and the alloy can have high oxidation resistance, corrosion resistance and welding performance in the field of petrochemical engineering; and meanwhile, in the process, through two times of vacuum melting, the mixed raw materials are fully melted and mixed at different vacuum degrees and gradually heated, so that the stability of the meltability of the solution is ensured, the mixing uniformity is improved, and the local accumulation caused by non-uniform mixing of the raw materials and the reduction of the quality of the nickel-based alloy are reduced.