47results about How to "Easy to scale up for industrialization" patented technology

The invention discloses a method for renaturing and purifying novel thrombopoietin mimetic peptide, the method comprises the following steps: performing a high density fermentation to escherichia coli engineering bacteria containing thrombopoietin mimetic peptide, carrying out an ultrasonication to thalline, urea cracking, renaturing, regulating the pH value, combining and purifying through Protein-AMabselectSuRe chromatography, SPSepharoseH.P chromatography and Sephacry1S-200 molecular sieve chromatography, and preparing thrombopoietin mimetic peptide protein which conforms to the Chinese pharmacopoeia specification. The beneficial effects of the present invention have high renaturation rate, reasonable purifying process combination, simplified operation program, high yield and low production cost, and the method provides the possibility for the large scale production of the thrombopoietin mimetic peptide.

The invention relates to the technical field of biological medicines, and particularly relates to a pyridine sulfonamide phosphate compound as well as a preparation method and application thereof. Thestructure of the pyridine sulfonamide phosphate compound is shown as a formula I shown in the specification. The pyridine sulfonamide phosphate compound has the beneficial effects that the pyridine sulfonamide phosphate compound has the characteristics of high solubility, high stability, convenience in preparation of preparations and the like, is easy to industrially amplify and is used for medical application.

The invention provides a molten bath and a method for recycling thermosetting epoxy resin or a composite material by using the same. The molten bath comprises at least one alkali metal hydroxide selected from lithium hydroxide, sodium hydroxide and potassium hydroxide and at least one additive, wherein the weight percentage ratio of the alkali metal hydroxide to the additive is (80-99.9): (0.1-20). The invention also provides a method for recycling the epoxy resin or the composite material by using the molten bath. By adopting the method, the thermosetting epoxy resin and the composite material thereof can be effectively decomposed under normal pressure, separation of the epoxy resin from an inorganic material is realized, the problems of low treatment efficiency and poor economic efficiency existing in the recycling process of old and useless epoxy resin and a composite material thereof are solved, and the decomposition rate of the epoxy resin or the epoxy resin in the composite material thereof is up to 90-100 percent. In the invention, industrialization is easy to amplify in a technical process, and a resource technology for effectively recycling epoxy resin or the composite material thereof is provided.

The invention belongs to the technical field of a preparation method for high-purity aromatic hydrocarbon pitch used for a high-end carbon material, and specifically relates to a preparation method for low-ash, low-sulfur and high-purity aromatic hydrocarbon pitch used for preparation of mesophase pitch. The preparation method comprises the following steps: dissolving aromatic hydrocarbon pitch into toluene, then adding a boron trifluoride-diethyl ether complex, carrying out stirring for layering at a normal temperature, separating out a high-density boron trifluoride-aromatic hydrocarbon pitch complex obtained at a bottom part, then adding the toluene and pyridine, further carrying out stirring for layering, removing a majority of the boron trifluoride, adding ammonia water and low-molecular alcohol or a surfactant, carrying out extraction for a plurality of times, and carrying out distillation so as to obtain the high-purity aromatic hydrocarbon pitch. The preparation method provided by invention is performed at a normal temperature, has low energy consumption and good purification and separation effects, is simple in equipment and low in investment and cost, and avoids the disadvantages of a conventional filtration and hydrogenation process.

The invention discloses a method for preparing a high-purity agaricus blazei murrill polysaccharide and provides a method capable of obtaining high content of the agaricus blazei murrill polysaccharide and suitable for large-scale production. The method comprises the following steps of: adding cellulase and pectinase to an agaricus blazei murrill powder; after adding water to the agaricus blazei murrill powder and uniformly stirring the water and the agaricus blazei murrill powder, regulating the pH value of a mixture to 6.0+ / -0.1; performing enzymolysis on the mixture for 40 minutes; carrying out microwave extraction on the mixture; freezing and drying agaricus blazei murrill water extract so as to obtain a concentrated product; carrying out decolorizing and primary impurity removal treatment on an agaricus blazei murrill polysaccharide extract solution by using a macroporous adsorbing resin; and then carrying out deproteinization treatment on the agaricus blazei murrill polysaccharide extract solution by using an ion exchange resin; further purifying the agaricus blazei murrill polysaccharide after deproteinization by using an ultrafiltration technology, so as to eliminate micromolecular water soluble substances; pre-freezing an agaricus blazei murrill polysaccharide ultrafiltrate to -60 DEG C; maintaining the agaricus blazei murrill polysaccharide ultrafiltrate at -60 DEG C for at least 4 hours; and drying the agaricus blazei murrill polysaccharide ultrafiltrate at -45 DEG C in a vacuum state so as to obtain the agaricus blazei murrill polysaccharide. Through the adoption of a microwave synergistic complex enzyme method, a resin deproteinization technology, an ultrafiltration process purification and freeze-drying technology, which are combined with each other, the purity of the agaricus blazei murrill polysaccharide reaches 90%.

The invention discloses a method for preparing a graphene carbon nanotube composite conductive framework for a lithium-sulfur battery. The method comprises the following steps: S1, preparing mixed slurry from graphene oxide and carbon nanotue powder; S2, adding a surfactant, mixing, and dispersing so as to obtain a graphene oxide carbon nanotube dispersant; S3, adding an adhesive and a curing agent, mixing, and dispersing so as to obtain a precursor solution; S4, evaporating the solution of the precursor solution, and performing curing treatment so as to obtain graphene oxide carbon nanotube composite precursor powder; and S5, performing high-temperature carbonization reduction, thereby obtaining a graphene oxide carbon nanotube three-dimensional composite conductive framework. The methodis simple and efficient in process step, low in cost and easy in industrial application, the microstructure carbon nanotubes of the prepared graphene oxide carbon nanotube composite powder are dispersed on the surface of graphene, a single-layer dispersion structure of the graphene is maintained, a good synergetic effect between the graphene and the carbon nanotubes is achieved, and the frameworkis an efficient three-dimensional conductive framework.

The present invention provides a process and system for producing natural gas from coal-fired self-heating catalytic gasification. Coal, catalyst and gasification agent are supplied to a gasification device, wherein the gasification agent is distributed and supplied from different positions of the gasification device to the gasification device. gasification unit, and oxygen is introduced into the gasification unit. According to the process for producing natural gas from coal-fired self-heating coal catalytic gasification disclosed in the present invention, the coal-fired self-heating method can provide the required heat for the catalytic gasification reaction, no additional heating equipment is required, the process is simple, and the technical economy is good , the single furnace realizes heat coupling, and the system efficiency is high; in addition, by providing gasification agent dispersedly to the gasification device, while providing the heat required for the reaction, it can control the oxygen distribution in the whole bed and adjust the oxygen distribution in the distribution plate and the bed. The ratio of steam and oxygen is used to control the oxygen concentration within a certain range, which can avoid local high temperature areas in the bed, thereby effectively avoiding slagging.

The invention discloses a water-soluble β-glucan, its preparation method and its application in the preparation of immune-enhancing and anti-tumor medicines and health care products. The present invention first prepares alkaline urea aqueous solution and freezes it, then adds insoluble β-glucan, freezes after stirring and dissolving, then heats to an appropriate temperature, adds hydrogen peroxide aqueous solution dropwise under stirring, adjusts pH to neutrality, and performs dialysis. The dialyzed internal fluid is concentrated under reduced pressure and freeze-dried to obtain water-soluble β-glucan. The method solves the technical problem that the insoluble β-glucan is difficult to degrade through the homogeneous degradation in the alkaline urea aqueous solution. The water-soluble β-glucan obtained by using the method can significantly enhance the immune activity of macrophage RAW 264.7 and effectively antagonize tumor cells. The β-glucan prepared by the present invention has the advantages of easy-to-obtain raw materials, simple preparation process, strong biological activity, and easy industrial production, and has the prospect of being developed as an immune-enhancing and anti-tumor drug.