Extraction method of acridine coumarin alkali F
An extraction method and technology for coumarin, applied in directions such as organic chemistry, can solve the problems such as the patent report on the extraction and purification method of acridine coumarin base that has not yet been seen, and achieve high economic benefits and academic value, short time consumption, and easy industrialization. zoom-in effect
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Embodiment 1
[0022] Take 1 kg of the root of grapefruit hybrid tangerine, crush it into a coarse powder, feed it from the feed inlet of the head of the continuous countercurrent ultrasonic extraction equipment, add 10 times of 95% ethanol solution from the solvent inlet at the tail of the continuous countercurrent ultrasonic extraction equipment, and carry out at 55 ° C. Continuous countercurrent ultrasonic extraction for 30 minutes, the ultrasonic frequency is 80KHz, to obtain the extract, the extract is decompressed to recover the reagent to obtain the extract, add alumina (120 mesh) to the extract, mix well, dry and pack the column, use 7 times the column volume Chloroform-acetone (1:1) mixed solution was eluted, TLC detection was performed, and acridine coumarin base F fractions were collected, concentrated and dried to obtain acridine coumarin base F crude product. With acetonitrile-0.2% ethylenediamine aqueous solution as the mobile phase, the volume ratio is 33:67, the chromatographi...
Embodiment 2
[0024] Take 1 kg of the root of grapefruit hybrid orange, crush it into coarse powder, feed it from the feed inlet of the head of the continuous countercurrent ultrasonic extraction equipment, add 10 times of 85% ethanol solution from the solvent inlet at the tail of the continuous countercurrent ultrasonic extraction equipment, and carry out at 45 ° C. Continuous countercurrent ultrasonic extraction for 100min, the ultrasonic frequency is 60KHz, to obtain the extract, the extract is decompressed to recover the reagent to obtain the extract, add alumina (80 mesh) to mix well, dry and pack the column, and use 4 times the column volume of chloroform-acetone ( 1:1) mixed solution for elution, TLC detection, collecting acridine coumarin base F fraction, concentrating and drying to obtain acridine coumarin base F crude product. Using acetonitrile-0.2% ethylenediamine aqueous solution as the mobile phase, the volume ratio is 33:67, the chromatographic column uses the C8 bonded phase ...
Embodiment 3
[0026] Take 10 kg of the root of grapefruit hybrid orange, crush it into coarse powder, feed it from the feed inlet of the head of the continuous countercurrent ultrasonic extraction equipment, add 6 times of 90% ethanol solution from the solvent inlet at the tail of the continuous countercurrent ultrasonic extraction equipment, and carry out at 35 ° C. Continuous countercurrent ultrasonic extraction for 50min, the ultrasonic frequency is 50KHz, to obtain the extract, the extract is decompressed to recover the reagent to obtain the extract, add alumina (100 mesh) and mix well, dry and pack the column, and use 6 times the column volume of chloroform-acetone ( 1:1) mixed solution for elution, TLC detection, collecting acridine coumarin base F fraction, concentrating and drying to obtain acridine coumarin base F crude product. With acetonitrile-0.2% ethylenediamine aqueous solution as the mobile phase, the volume ratio is 33:67, the chromatographic column uses the C8 bonded phase ...
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