The invention relates to a synthetic method of 2-(2-amino-4-thiazolyl)-2-(Z)-methoxyimino
acetic acid, which belongs to the synthetic methods of heterocyclic compounds containing 1,3-
thiazole ring. The synthetic method is characterized by comprising the following operation steps: 1) homogeneous oximation reaction: preparing 2-hydroxamic
ethyl acetoacetate; 2)
methylation reaction: preparing 2-methoxyimino
ethyl acetoacetate; 3)
triphosgene chlorination reaction: preparing 4-chloro-2-methoxyimino
ethyl acetoacetate; 4) cyclization reaction: preparing 2-(2-amino-4-thiazolyl)-2-(Z)-methoxyimino
acetic acid ethyl ester; 5)
hydrolysis: preparing a crude product of the 2-(2-amino-4-thiazolyl)-2-(Z)-methoxyimino
acetic acid; and 6) refining: preparing a product of the 2-(2-amino-4-thiazolyl)-2-(Z)-methoxyimino acetic acid. The invention provides an oximating agent
system which is applicable to homogeneous nitrosification reaction. The invention provides a
triphosgene chlorinating agent which has the advantages of small
toxicity, safe and convenient storage, transportation and use, easy control of
process operation and high yield. The yield of the 2-(2-amino-4-thiazolyl)-2-(Z)-methoxyimino acetic acid
ethyl ester is not less than 95.4%; the yield of the crude product of the 2-(2-amino-4-thiazolyl)-2-(Z)-methoxyimino acetic acid is not less than 94.4%; and the yield of the finished product of the 2-(2-amino-4-thiazolyl)-2-(Z)-methoxyimino acetic acid is not less than 90.5%. The purity of the finished product of the 2-(2-amino-4-thiazolyl)-2-(Z)-methoxyimino acetic acid is not less than 99.06%, and the
melting point is 182.1 DEG C-183.9 DEG C. The synthetic method is used for synthesizing raw materials of the
third generation of cephalosporins.