Novel synthesizing method of dapoxetine
A technology of dapoxetine and a synthesis method, applied in a new synthesis field, can solve the problems of complicated operation, unfavorable industrial production, high price and the like, and achieves the effects of cheap raw materials, low cost and simple separation
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[0058] In order to make the technical means, creative features, work flow, and use methods of the present invention achieve the purpose and effect easily understood, the present invention will be further described below in conjunction with specific embodiments.
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[0069] Synthesis of chiral catalyst (s)-α,α-diisopropyldimethyl-tert-butylsilyloxyprolinol:
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[0074] Synthesis of Intermediate 1:
[0075] Add 31.2 grams of magnesium powder (1.30mol) and 50 milliliters of methyl tert-butyl ether into the reaction flask, under stirring, under nitrogen protection, slowly add 147.6 grams of 2-bromopropane (1.20mol) in methyl tert-butyl ether 500ml of ether solution (15ml will be added dropwise first, and after the reaction is triggered, slowly add the remaining solution...
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