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67 results about "Procaine Hydrochloride" patented technology
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The hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.
Method for inhibiting inflammation
InactiveUS6194456B1Increase injection volumePotentiation of duration of actionBiocideAntipyreticVasodilationBULK ACTIVE INGREDIENT
A drug which is preferably usable for inhibiting inflammation in chronic and autoimmune inflammatory processes and / or produces vasodilating and sympathicolytic effects.This use is achieved through a drug from a mixture containing a local anesthetic of the ester type or amide type, preferably procaine hydrochloride, water, and at least one substance for adjusting the pH of the mixture in the range of 7.6 to 8.6. It is possible by this drug to significantly increase the injectable amount of local anesthetic compared with commercially available and known drugs containing a local anesthetic as active ingredient. The mixture can be applied continuously by subcutaneous or intravenous infusion.
Owner:MEDICUR PHARMA
Method for determining procaine hydrochloride content in gentamycin procaine vitamin B12 particle by high performance liquid chromatography
InactiveCN102226790AThe measurement result is accurateAccurate and reliable measurement resultsComponent separationInjection volumeSilanes
The invention relates to a method for determining the procaine hydrochloride content in a gentamycin procaine vitamin B12 particle by high performance liquid chromatography, and the chromatographic conditions adopted by the method include that: an octadecyl silane bonded silica gel column is employed as a chromatographic column; a mobile phase is prepared by water, acetonitrile and triethylamine with a volume ratio of 85:15:0.02 and is adjusted by glacial acetic acid to obtain a pH of 3.9; a column temperature is 35 DEG C; a detection wavelength is 292 nm; a flow speed is 1.0 ml / min; and an injection volume is 20 microliter. The determination result of the procaine hydrochloride content in a gentamycin procaine vitamin B12 particle obtained by the method of the invention is accurate and reliable, and the method is simple and scientific. The test time is short; no interference peak appears; the theoretical plate number is up to above 2000; the resolution, the tailing factor, and the asymmetry degree all meet the requirements of Chinese pharmacopoeia; and the detection results is good.
Owner:NINGBO SHUANGWEI PHARMA
Neuro-degenerative inhibitor, neuro-endocrine modulator, and neuro-cerebral metabolism enhancer
InactiveUS20100189819A1Minor side effectsMinimal toxicityBiocideSenses disorderEndocrine functionsNiacinamide
Neuro-metabolic and endocrine-function regulating / modulating compositions, are disclosed. The compositions of the present invention comprise Selegiline Hydrochloride, Procaine Hydrochloride, Vinpocetine, trimethylglycine, and an ingredient selected from a group consisting of N-nicotinoyl-gamma-aminobutyric acid (N-GABA), niacin, niacinamide, gamma-aminobutyric acid (GABA), and combinations thereof. Methods of using the compositions, compositions, and compositions of the present invention are also disclosed.
Owner:INTRATHERAPIES
Diluent for blood cell analysis instrument
InactiveCN1548942AEasy to manufactureAdd diffuse effectPreparing sample for investigationIndividual particle analysisPhosphoric acidSodium sulfate
The diluent for hemocyte analyzer includes sodium hydroxide 430-470 g / L, dimethylol urea 0.8-1.2 g / L, phosphoric acid 430-470 ml / L, non-ionic surfactant 0.3-0.7 g / L, procaine hydrochloride 0.09-0.13 g / L, anhydrous sodium sulfate 1.0-9.5 g / L, and sodium chloride 0.3-0.7 g / L except water. The diluent of the present invention may be used in various kinds of hemocyte analyzer.
Owner:上海捷瑞医用试剂有限公司
Non-isotonic preserving fluid for liquid-based thin-layer exfoliative cells
ActiveCN103461320AImprove the detection rateFacilitates histochemical stainingDead animal preservationMethyl aldehydeSodium phosphates
The invention discloses a non-isotonic preserving fluid for liquid-based thin-layer exfoliative cells, and is characterized by comprising the following raw materials by weight: 9-11 parts of methyl aldehyde, 13-16 parts of ethyl alcohol, 9-9.5 parts of glycine, 3-3.5 parts of carbamide, 1.8-2.2 parts of procaine hydrochloride, 1.3-1.6 parts of propylene glycol, 1.4-1.6 parts of dimethyl sulfoxide, 0.8-1.2 parts of sodium phosphate, 3.4-3.6 parts of trypsin, 0.1-0.3 part of acetic acid, 1-1.1 parts of disodium hydrogen phosphate, 0.3-0.32 part of sodium dihydrogen phosphate, and 51-52 parts of water. Compared with the prior art, the non-isotonic preserving fluid has the advantages as follows: buffer solution fixed cells by the formula of the non-isotonic preserving fluid facilitate histochemical stain; the solution utilizing the colligative property of a non-ionic solution splits red blood cells and dissolves mucus protein during the hydroformylation process, so that the microscopic examination background becomes clear, and the detection rate of positive cells is greatly improved.
Owner:安徽信灵检验医学科技股份有限公司
Anti-aging medicament for treating coronary heart disease and hyperlipemia, and preparation method thereof
ActiveCN101411821AEffective treatmentOrganic active ingredientsMetabolism disorderWestern medicineSide effect
The invention discloses a composite drug of traditional Chinese medicine and western medicine for treating coronary artery disease and hyperlipidemia and resisting aging. The drug is prepared from the following raw materials in weight portion: 10 to 37 portions of ginseng, 26 to 77 portions of polygonum multiflorum, 26 to 77 portions of rhizoma polygonati, and 15 to 51 portions of procaine hydrochloride. The drug can effectively treat the coronary artery disease and the hyperlipidemia, and can simultaneously achieve the aim of resisting aging. Besides, the drug does not have toxic side effects.
Owner:洛阳新春都生物制药有限公司
Medical composition kit for treating lesioned abnormal tissue
InactiveUS7381419B2Mitigating local painAffecting effectiveness of treatmentBiocideGogglesWater solubleLocal injection
Optimum compounding composition of a local injection preparation for treating rectal submucous lesioned abnormal tissue with local anesthetic is decided to provide a medical composition kit. In a composition kit for the treatment where respective containers are unsealed upon being used and respective contents are mixed to obtain a preparation for injection, a medical composition kit which is characterized in that respective single doses of a therapeutic preparation and local anesthetic are fractionally charged in containers, the said therapeutic preparation contains 1˜10% of a water-soluble aluminum compound and 0.01˜2% of tannic acid and the said local anesthetic contains 0.1˜1% of lidocaine hydrochloride or 0.5˜5% of procaine hydrochloride.
Owner:LEQUIO PHARMA +1
Preparation method of granules for diminishing inflammation, relieving pain and promoting gastric mucosa repair
InactiveCN103006682AQuality improvementImprovement ingredientsOrganic active ingredientsAntipyreticFluidized bed dryingSucrose
The invention relates to a preparation method of granules for diminishing inflammation, relieving pain and promoting gastric mucosa repair. The preparation method comprises the following steps of: crushing procaine hydrochloride and cane sugar till the particle sizes of the two components can be 80 meshes; dosing and weighing, wherein gelatin is taken, and the weight ratio of gentamycin sulfate (calculated by anhydride) to procaine hydrochloride (calculated by anhydride) to vitamin B12 to the cane sugar is 20mg: 0.1g: 0.02mg: 4.81g; preparing a binding agent; granulating, wherein the procaine hydrochloride and the cane sugar are sequentially poured into a fluidized bed drying granulator, solution of the gentamycin sulfate and the vitamin B12 is sprayed into the mixture after the procaine hydrochloride and the cane sugar are fully mixed for 15 minutes, then aqueous solution of the gelatin is taken as the binding agent for spraying fluidized granulation, the granulation temperature is controlled in a range of 50+ / -5 DEG C, the drying temperature is controlled in a range of 65+ / -5 DEG C, the drying lasts for 20 minutes and stops after the granules are formed and then the granules are obtained; granulating; and totally mixing the granules. The preparation method has the advantage of obtaining the granules with good quality.
Owner:上海海虹实业(集团)巢湖今辰药业有限公司
Method for producing compound procaine hydrochloride capsules
ActiveCN105147638AImprove liquidityHigh dissolution rateNervous disorderHydroxy compound active ingredientsBenzoic acidPrill
The invention discloses a method for producing compound procaine hydrochloride capsules. According to the method, procaine hydrochloride, glutamic acid and starch are premixed and then smashed and screened, and potassium metbisulphite, talcum powder and benzoic acid are premixed and then smashed and screened; monopotassium phosphate is dissolved in purified water to serve as a bonding agent, then a soft material is made with an efficient wet granulation machine by means of procaine hydrochloride, vitamin B6, inositol, glutamic acid and starch, granulation is conducted with a swing type granulation machine, drying is conducted, and the potassium metbisulphite, the benzoic acid and the talcum powder are added during total blending. By the adoption of the method, the problem of traditional methods that a large amount of irritating odor is generated during production is solved, prepared granules are high in mobility and dissolution rate, filling is smooth, and the manufacturing technique is more stable. Operation is easy, preparation is convenient, cost is low, and the method is suitable for industrial large-scale production.
Owner:CHENGDU TONGDE PHARMA
Western medicine ointment for eliminating abscess
InactiveCN108186660ADelicate appearanceBroaden applicationAntipyreticAerosol deliveryPolyethylene glycolDiphenhydramine hydrochloride
The invention discloses a western medicine ointment for eliminating abscess. The ointment is prepared from, by weight, 5-15 parts of erythromycin; 20-30 parts of ciprofloxacin; 10-20 parts of mupirocin; 8-15 parts of polyethylene glycol; 8-15 parts of benzalkonium chloride; 5-10 parts of triethanolamine; 10-15 parts of glycerin; 5-10 parts of laurocapram; 0.1-0.5 part of ethylparaben, 1-3 parts ofsodium lauryl sulfate, 5-15 parts of benzalkonium chloride; 5-10 parts of methyl salicylate; 2-10 parts of diphenhydramine hydrochloride; 5-15 parts of procaine hydrochloride; 100-150 parts of water.The ointment is simple in formula and has effects of promoting ulcer wound healing and eliminating abscess. The ointment has the advantages of exquisite appearance, easy application, moderate consistence, heat resistance, cold resistance, rapid effect and short treatment period and meets the current use requirements.
Owner:刘春霞
Preparation method of synergistic tylosin tartrate soluble powder compound medicine
InactiveCN103405463AWide range of indicationsGood curative effectAntibacterial agentsOrganic active ingredientsTrimethoprimSecondary Infections
The invention aims at providing a preparation method of a synergistic tylosin tartrate soluble powder compound medicine. The synergistic tylosin tartrate soluble powder compound medicine has a rapid and definite curative effect on respiratory system infections and complications of livestock and poultry. The preparation method comprises the following steps of: mixing 0.2 part of trimethoprim and 0.2 part of cosolvent, then crushing, and sieving by using a 120 meshes sieve or a finer sieve; and then uniformly mixing with 1 part of tylosin tartrate, 1 part of kanamycin sulfate and 0.05-0.1 part of pain alleviant by an equivalently successive increase method, thus obtaining the synergistic tylosin tartrate soluble powder compound medicine. The cosolvent is citric acid or succinic acid or the mixture of citric acid and succinic acid and the pain alleviant is procaine hydrochloride or lidocaine hydrochloride or the mixture of procaine hydrochloride and lidocaine hydrochloride. The animal synergistic tylosin tartrate soluble powder compound medicine for injection contains three medical components which are tylosin tartrate, kanamycin sulfate and trimethoprim, can be used for solving the problems that the secondary infection cannot be controlled very well during the treatment of mycoplasma infection due to the narrow antibacterial spectrum of the tylosin tartrate, and the trimethoprim is insoluble in water, has a synergistic effect on tylosin tartrate and kanamycin sulfate and has an obvious medicine curative effect.
Owner:四川联美生物药业有限公司
Emplastrum for treating blood stasis type scapulohumeral periarthritis
InactiveCN106880725APharmacological effect of strong blood circulation and blood stasis removalSolve the root cause of poor blood circulationInorganic boron active ingredientsAntipyreticSide effectDiphenhydramine hydrochloride
The invention relates to the field of traditional Chinese medicines, and provides a Chinese and western medicine external patch for treating scapulohumeral periarthritis. An emplastrum is prepared from the following active ingredients and auxiliary materials in parts by weight; the active ingredients comprise 0.1 to 0.3 part of moschus, 100 to 200 parts of radix notoginseng, 50 to 100 parts of safflower, 50 to 100 parts of radix salviae miltiorrhizae, 1.2 to 1.8 parts of boric acid, 1.2 to 1.8 parts of root of cinnamomum camphora, 3 to 6 parts of dragon's blood, 1 to 5 parts of urea, 10 to 20 parts of extractum belladonnae liquidum, 0.5 to 1.5 parts of diphenhydramine hydrochloride, and 1 to 3 parts of procaine hydrochloride; the auxiliary materials comprise 280 to 350 parts of rubber, 120 to 160 parts of rosin, 350 to 450 parts of zinc oxide, 30 to 50 parts of lanolin, and 10 to 20 parts of vaseline. The emplastrum has the advantages that the effects of activating blood circulation and dredging collaterals, and sterilizing bacteria and relieving pain are realized, the emplastrum quickly takes effect, the curative effect is obvious, any side effect is avoided, the safety is high, the convenience in use is realized, and the like; the effect of treating the scapulohumeral periarthritis is obvious, and the curative rate is 92%.
Owner:毛嘉明
Method for detecting content of procaine hydrochloride solution
The invention is a new method for measuring the content of procaine hydrochloride solution. The method is: pipetle the procaine hydrochloride solution 1.0ml precisely, and put into 100ml cylinder, adds in purified water to dilute them to the scale and acquires the sample solution, the sample solution and purified water are put into two color comparators, carries on measurement according to the operation demands of ultraviolet spectrum device UV-2550, the wavelength of the device is set as 308nm, measures the amplitude D between its first order of derivative valley and zero, then the D is substituted in the formula D=0.00252C+0.0001, the C is the content of procaine hydrochloride in solution. The method is accurate and quick.
Owner:刘素琴
Compound tablet for treating gastritis and preparation thereof
InactiveCN1679616AGood killing effectReduce irritative secretionOrganic active ingredientsDigestive systemGastritisMedicine
A compound medicine in the form of tablet for treating gastritis contains proportionally gentamycin sulfate, procaine hydrochloride, VB12 and medicinal additives.
Owner:海南康福中正发展有限公司 +1
Procaine hydrochloride drug intermediate p-nitrobenzoic acid synthesis method
InactiveCN108238951AAvoid pollutionReduction of intermediate links in the reactionOrganic chemistryOrganic compound preparationP-nitrobenzoic acidAlcohol
The invention discloses a procaine hydrochloride drug intermediate p-nitrobenzoic acid synthesis method, which comprises: adding 4-nitro-6-hydroxybenzyl alcohol in a reaction container, increasing thetemperature of the solution, controlling the stirring, adding a 3-methyl-2-butanone solution and samarium oxide powder, increasing the temperature of the solution, continuously carrying out the reaction, reducing the temperature of the solution, filtering, washing multiple times with a potassium sulfate solution, washing multiple times with an oxalic acid solution, washing multiple times with a 2-chloro-2-methylpropane solution, re-crystallizing in a thiodiglycol solution, and dehydrating with a dehydrating agent to obtain the finished product p-nitrobenzoic acid.
Owner:CHENGDU QIESITE TECH CO LTD
Musk cream for promoting blood circulation to remove blood stasisand hot press molding method thereof
InactiveCN110075200AHigh viscoelasticityPrevent agingInorganic boron active ingredientsAntipyreticWhite petrolatumDiphenhydramine hydrochloride
The invention relates to musk cream for promoting blood circulation to remove blood stasis and a hot press molding method thereof. The musk cream for promoting blood circulation to remove blood stasisis prepared from the following components in parts by weight: 1-3 parts of muskone, 8-12 parts of boric acid, 5-8 parts of camphor, 30-35 parts of sanguis draconis, 15-20 parts of urea, 110-120 partsof belladonna fluid extract, 4-7 parts of diphenhydramine hydrochloride, 10-14 parts of procaine hydrochloride, 400-500 parts of an extract for promoting blood circulation to remove blood stasis, 2000-2100 parts of rubber, 900-1000 parts of rosin, 2600-2700 parts of zinc oxide, 210-230 parts of lanolin, 90-110 parts of petroleum jelly and 260-280 parts of 95% ethanol. The hot press method comprises the steps of cutting a sizing material, refining the sizing material, kneading, filtering, baking the sizing material and gluing. The musk cream for promoting blood circulation to remove blood stasis, prepared by the method disclosed by the invention, is easy for gluing because the sizing material is soft, a product has great cohesive force and strengthened adhesion, and has no residual residueon skin after application, and the curative effect is good; a preparation process is simple, achieves high production efficiency and low cost, can meet safe production conditions, and is suitable formass production.
Owner:GUIZHOU LIANSHENG PHARMA
Swelling and pain relieving ointment and preparation method thereof
InactiveCN109091584ABroaden applicationModerate consistencyHydroxy compound active ingredientsAntipyreticDiphenhydramine hydrochlorideExternal Ointment
The invention discloses a swelling and pain relieving ointment, relates to the technical field of external ointment and aims to solve the problems that existing ointments have single components and cannot remove root causes. The ointment is prepared from raw materials as follows: Vaseline, erythromycin, mupirocin, borneol, iodine tincture, glycerin, laurocapram, procaine hydrochloride, diphenhydramine hydrochloride and traditional Chinese medicine composition. The invention also discloses a preparation method of the swelling and pain relieving ointment. The prepared ointment is fine in appearance, easy to coat, medium in thickness and resistant to cold and heat and has the functions of promoting healing of ulcer wounds and removing abscess, Vaseline is used as a matrix, borneol fully playsthe role in relieving pain and promoting granulation, iodine tincture and erythromycin inhibit bacteria and diminish inflammation, traditional Chinese medicines are added for matched use, so that theointment has effects of dredging collaterals, reducing phlegm, resolving masses, promoting blood circulation to remove blood stasis and relieving swelling and pain, western medicines and traditionalChinese medicines have a synergistic effect, the swelling and pain relieving effect is better, and the ointment has wide market prospects.
Owner:何凤姣
Preparation method of medicine for treating respiratory system infection of livestock and poultry
InactiveCN103405465ASolve the problem of insoluble in waterFormulation stabilityAntibacterial agentsOrganic active ingredientsTreatment effectTrimethoprim
The invention aims at providing a preparation method of a medicine for treating respiratory system infection of livestock and poultry. The medicine has rapid and accurate treatment effects on respiratory system infection and complications of livestock and poultry. The medicine is prepared by the following steps: mixing and crushing 0.2 part of trimethoprim and 0.2 part of a cosolvent, and then sieving the mixture through a 120-mesh sieve or a finer sieve; and uniformly mixing the sieved product with 1 part of tylosin tartrate, 1 part of kanamycin sulfate and 0.05-0.1 part of a pain reliever by a method of progressively increasing by equal quantity, wherein the cosolvent is citric acid, succinic acid or a compound of the two, and the pain reliever is procaine hydrochloride, lidocaine hydrochloride or a compound of the two. The synergism compound tylosin tartrate for livestock injection provided by the invention contains three components, namely the tylosin tartrate, kanamycin sulfate and trimethoprim; the problem that secondary infection cannot be well controlled due to the narrow antibacterial spectrum of the tylosin tartrate when mycoplasma infection is treated can be solved; the problem that the trimethoprim is poorly soluble in water can be solved, a synergism effect of the tylosin tartrate and kanamycin sulfate can be achieved, and the medicine has an obvious treatment effect.
Owner:SICHUAN DERUNTONG BIOTECH
Pharmaceutical composition for treating piles as well as preparation method and application thereof
ActiveCN102579569AAnti-inflammatoryHas pain reliefHydroxy compound active ingredientsCardiovascular disorderIntestinal structureDisease
The invention provides a pharmaceutical composition for treating piles, which is a suppository. The invention also provides a preparation method and application of the pharmaceutical composition. The pharmaceutical composition is prepared from the following components in parts by weight: 80-120 parts of berberine hydrochloride, 7-20 parts of procaine hydrochloride, 1.5-4.2 parts of hydrocortisone, 7-18 parts of borneol, 3.5-6.5 parts of menthol and 1000 parts of fat-soluble matrix. The pharmaceutical composition can directly reach piles infected part through rectal administration, thus the side effect of enterohepatic circulation due to oral administration is reduced. The pharmaceutical composition for treating piles provided by the invention can be used for solving the defect that oral administration is slow in acting for diseases in intestine, can substitute for the traditional operative treatment, is convenient to use and does not damage organisms.
Owner:BEIJING RECTUM HOSPITAL
Anesthetic oral liquid for gastric surgery, and preparation method thereof
InactiveCN110179888AGood local anesthesiaLittle side effectsDispersion deliveryHydroxy compound active ingredientsSolubilityTreatment effect
Owner:WUHAN SHENGRUN BIOTECHNOLOGY CO LTD
Drug for treating toothache
InactiveCN102940696ANo significant differenceComparableOrganic active ingredientsDigestive systemCreosoteGlycerol
The invention relates to a drug for treating toothache, which is prepared with the raw materials by the following volume ratio: 0.140-0.146 parts of creosote, 1.13-1.15 parts of glycerin, 0.05-0.07 parts of clove oil, 0.05-0.07 parts of tincture aconite, 0.005-0.015 parts of anise oil, 0.01-0.03 parts of procaine hydrochloride solution with 0.5% of mass concentration, 0.13-0.15 parts of camphor oil, 0.03-0.05 parts of chloroform and 1.1-1.3 parts of ethanol with 75% of mass concentration. Experiments show that the drug can fast, safely and effectively treat toothache.
Owner:辛晓林
Gastrodin injection and preparation process thereof
ActiveCN103520095ALess prone to white spotsHigh clarityOrganic active ingredientsNervous disorderGlycineCLARITY
The invention provides a gastrodin injection and a preparation process thereof, and the gastrodin injection can be used for reducing white spots and white blocks occurring during storage, improving the clarity, guaranteeing the safety of medication and meanwhile guaranteeing better stability. According to the gastrodin injection and the preparation process thereof, lactose, procaine hydrochloride, sodium hyposulfite, niacinamide and glycine are used as auxiliary materials; the white spots and the white blocks occurring during storage can be reduced, the clarity can be improved and the safety of medication can be guaranteed after proportioning; but meanwhile, we found that the gastrodine content is obviously reduced after the gastrodin injection is stored for a period of time after the auxiliary materials are added; after the addition sequence of the auxiliary material is adjusted by using the special technology, the content of the gastrodine in the gastrodin injection is still stable after long-time storage, so that the validity of the clinical medication is guaranteed.
Owner:JIANGXI GUOYAO PHARMA LLC
Drug for treating gastric ulcer and preparing method thereof
InactiveCN106728071AWide variety of sourcesPromote circulationHeavy metal active ingredientsPowder deliveryTreatment costsHelicobacter pylori gastritis
The invention discloses a drug for treating a gastric ulcer. The drug is prepared from, by weight, auxiliary materials, anthocyanin, alprazolam, oryzanol, virustat, metronidazole, veytalo tablets, vitamins, procaine hydrochloride, acyclovir and ethanol solution. The invention further discloses a method for preparing the drug. The raw materials are widely available, the preparing process is simple, and the drug is suitable for large-scale industrial production. Through the synergistic effect of the components like vitamins, alprazolam, anthocyanin and veytalo tablets, the drug can effectively and radically kill helicobacter pylori and dissolve and remove a decayed layer of an ulcer face together with gastric acid, and can also remove slough and promote growth of tissue regeneration, promote blood circulation, accelerate growth of new tissue, completely repair an ulcer face and recover gastric dynamics, so as to radically cure a gastric ulcer. The drug is easy to use, short in treatment time and low in treatment cost, and relapse does not occur easily.
Owner:郑州莉迪亚医药科技有限公司
Procaine penicillin, preparation method thereof, impurity and impurity control method
PendingCN114262337ANon-genotoxicIncrease awarenessOrganic compound preparationComponent separationBenzoic acidPhysical chemistry
The invention provides procaine penicillin as well as a preparation method, an impurity and an impurity control method thereof. The content of an RRT 0.24 impurity in the procaine penicillin is less than 0.13%. According to the preparation method, the content of an RRT0.24 impurity in a used raw material procaine hydrochloride is controlled to be not higher than 0.05%, and the RRT0.24 impurity is 2-{[2-(4-aminobenzoyloxy) ethyl] (ethyl) amino} ethyl-4-aminobenzoate. The content y of the RRT 0.24 impurity in the product procaine penicillin and the content x of the RRT 0.24 impurity in the raw material procaine hydrochloride meet a linear relation model y = 2.4835 x, wherein the model R2 = 0.9546. The invention discloses a novel impurity of procaine penicillin, which plays an important role in quality control of procaine penicillin.
Owner:NORTH CHINA PHARM GRP SEMISYNTECH CO LTD
Compound synergistic tylosin tartrate
ActiveCN103405466ASolve the problem of insoluble in waterFormulation stabilityAntibacterial agentsPowder deliveryTrimethoprimSecondary Infections
The invention relates to a compound synergistic tylosin tartrate. The invention aims to provide an compound synergistic tylosin tartrate for injection for livestock, which has quick and definite curative effect on livestock and fowl respiratory system infections and complications. The medicine is composed of the following components in parts by weight: 1 part of tylosin tartrate, 1 part of kanamycin sulfate, 0.2 part of trimethoprim, 0.2 part of cosolvent and 0.05-0.1 part of pain relieving agent. The cosolvent is citric acid or succinic acid or compound of both, and the pain relieving agent is procaine hydrochloride or lidocaine hydrochloride or compound of both. The compound synergistic tylosin tartrate for injection for livestock contains the three pharmaceutical components, including tylosin tartrate, kanamycin sulfate and trimethoprim. The invention solves the problem of incapability of well controlling the secondary infection due to the narrow antimicrobial spectrum of the tylosin tartrate in treating mycoplasma infection, solves the problem of insolubility of trimethoprim in water, has a synergistic effect on tylosin tartrate and kanamycin sulfate, and is accurate in dosage and convenient to use.
Owner:金河牧星(重庆)生物科技有限公司
Method for detecting diethylaminoethanol in procaine hydrochloride
The invention belongs to the technical field of pharmaceutical analysis and in particular relates to a method for detecting diethylaminoethanol in procaine hydrochloride. The method comprises the following steps: (1), preparing a test solution; to be specific, taking procaine hydrochloride, dissolving the procaine hydrochloride by using a solvent, and diluting the solution into a solution of 10 mg / mL to 50 mg / mL; (2), preparing a reference solution; to be specific, taking a diethylaminoethanol reference substance, dissolving the diethylaminoethanol reference substance by using a solvent, and carrying out dissolution to obtain a solution of 0.05mg / mL to 0.5mg / mL; (3), taking the test solution and the reference solution respectively, carrying out sample application on a same silica gel thinlayer plate, carrying out expansion at a saturate tank, and carrying out drying by cold air; (4), carrying out development; to be specific, carrying out fumigation and development in iodine vapor; and(5), carrying out result determination; to be specific, a spot of a corresponding position of diethylaminoethanol is displayed in a sample and the spot is compared with a reference substance spot color to avoid the deeper color. Therefore, the quality of procaine hydrochloride can be controlled effectively. The operation becomes simple, convenient, and rapid; no special detection instrument is needed; and economical and practical effects are good.
Owner:SHANDONG QIDU PHARMA
External medicine for treating skin diseases of pet dog
InactiveCN105012330AThe route of administration is simple and convenientLow toxicityOrganic active ingredientsAntipyreticDiseaseSide effect
The invention discloses an external medicine for treating skin diseases of a pet dog. The external medicine is prepared from the following medicines: 0.2-0.5 ml of Dectomax doramectin, 10 ml of gentamycin sulfate, 10 ml of lincomycin hydrochloride, 10 ml of procaine hydrochloride, 5 ml of dexamethasone sodium phosphate, and 80-100 ml of metronidazole. According to the external medicine for treating the skin diseases of the pet dog, the Dectomax doramectin is taken as the main element, so that the side effect is small, the external medicine can be directly smeared on affected parts, an administration route is sample and convenient, the toxicity is small, the costs are low, the operations are easy, and the curative effect is achieved quickly.
Owner:HEILONGJIANG PATENT TECH DEV
Compound synergistic tartaric acid tylosin for injection of livestock
InactiveCN102784159ASolve the problem of insoluble in waterFormulation stabilityAntibacterial agentsPowder deliveryTrimethoprimSecondary Infections
The invention relates to a compound synergistic tartaric acid tylosin for injection of livestock and aims at providing a compound synergistic tartaric acid tylosin, which can be used for achieving a rapid and definite curative effect on the breathing system infection and complications of livestock, for injection of livestock. The medicine comprises the following components in parts by weight: 1 part of tartaric acid tylosin, 1 part of kanamycin sulfate, 0.2 parts of trimethoprim, 0.2 parts of cosolvent and 0.05-0.1 parts of pain alleviator, wherein the cosolvent is citric acid or succinic acid or a combination of the citric acid and the succinic acid; and the pain alleviator is procaine hydrochloride or lidocaine hydrochloride or a combination of procaine hydrochloride and the lidocaine hydrochloride. The compound synergistic tartaric acid tylosin for injection of livestock contains medicine components of three types, namely tartaric acid tylosin, kanamycin sulfate and trimethoprim, can be used for solving the problems that tartaric acid tylosin is narrow in antimicrobial spectrum and cannot well control secondary infection during the treatment of mycoplasma infection and the problem that trimethoprim is insoluble in water, and achieving a synergy effect on tartaric acid tylosin and kanamycin sulfate, and is accurate in dosage and convenient in use.
Owner:SICHUAN DERUNTONG BIOTECH
Procaine hydrochloride micro-capsules and preparation method thereof
ActiveCN105919969AGreat tasteGood treatment effectOrganic active ingredientsAnaestheticsUse medicationSide effect
The invention provides procaine hydrochloride micro-capsules. The procaine hydrochloride micro-capsules are prepared from procaine hydrochloride powder and a capsule material coating the procaine hydrochloride powder, wherein the mass ratio of the procaine hydrochloride powder to the capsule material is 1 to 1-6, and the capsule material is a cellulose derivative, acrylic resin RL100, gelatin, arabic gum or alginate. The invention further provides a preparation method of the procaine hydrochloride micro-capsules. The procaine hydrochloride micro-capsules can improve the stability of procaine hydrochloride, reduce side effects, reduce various adverse drug reactions and improve the medication compliance of patients.
Owner:ZHENGZHOU BARY ANIMAL PHARMA
Oral local anesthetic preparation and preparation method thereof
InactiveCN105902681AReduce the injection doseAvoid painOrganic active ingredientsPharmaceutical delivery mechanismPhysochlaina infundibularisLocal anesthetic
The invention discloses an oral local anesthetic preparation and a preparation method thereof and belongs to the field of surface local anesthesia medicine. The preparation is prepared from procaine hydrochloride, metronidazole, ethylene diamine tetraacetic acid, traditional Chinese medicine extracts and 0.9% sodium chloride normal saline. The traditional Chinese medicine extracts are prepared from oreoselinum extracts, mysorethorn extracts, wild pepper extracts, physochlaina infundibularis extracts, Erodium stephanianum Willd extracts, radix scutellariae extracts, coptidis rhizoma extracts, dandelion extracts and rhizoma chuanxiong extracts. Procaine hydrochloride is combined with traditional Chinese medicine extract components such as oreoselinum, mysorethorn and wild pepper, so that a series of adverse reactions such as muscular pain, tooth pain and heart attack caused when conventional procaine hydrochloride injections are applied to oral anesthesia are avoided, the anesthetic effect is improved, and anesthetic time is prolonged; dosage of procaine hydrochloride injection is reduced, the effects of stopping pain, calming the nerves and stopping bleeding are improved, and safety is improved.
Owner:雷知雅
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