33 results about "Enterohepatic circulation" patented technology

The invention discloses an artificial bear bile powder and a preparation method thereof. The preparation method comprises the following steps: a) dissolving poultry bile powder with a buffer solution of pH=7-9 and then filtering to obtain filter residue and filtrate; b ) adding the filtrate to a reactor equipped with 7α-hydroxysteroid dehydrogenase, 7β-hydroxysteroid dehydrogenase and coenzyme I or coenzyme II for reaction; c) freeze-drying the reaction solution after the reaction and combining with the The filter residue is mixed to obtain artificial bear bile powder. The present invention completely uses natural sources of poultry bile as the raw material for artificial bear bile, without adding other chemical substances, and adopts common animal bile, and its bile source is easy to collect, obtain, and process; through in vitro simulation of the enterohepatic circulation process , to bioconvert poultry bile into artificial bear bile powder that is chemically equivalent to natural bear bile powder, as a substitute for natural bear bile, to protect the endangered Asian black bear, and to promote the healthy development of the bear bile industry.

The invention relates to a synthetic method of 13C marked glycocholic acid, and the method comprises the following steps: under the protection of nitrogen, 13C marked glycine benzyl ester hydrochloride and cholic acid are mixed and dissolved in a polar solvent, then coupling reagent is added, the reaction temperature is controlled between minus 20 and 150DEG C, the reaction time is 0.1 to 120h, and then the product is obtained after separation and purification by a silica gel column. The method adopts the coupling agent to synthesize the 13C marked glycocholic acid, the yield of the glycocholic acid can achieve above 80 percent, the abundance of 13C can achieve 99atm%, the optical purity can achieve 98 percent, and the chemical purity can achieve 98 percent. The obtained 13C marked glycocholic acid can be used as medical diagnosis reagent and can be used for enterohepatic circulation of the cholic acid, overgrowth of intestinal bacteria, activity evaluation of bacterial metabolism andthe like.

The invention discloses a traditional Chinese medicine enema for treating non-alcoholic steatohepatitis and its preparation method and application method. . Based on the theory of "gut-liver axis", the present invention adopts the method of retention enema to make the drug directly absorbed through the intestinal mucosa, reduce the damage to the drug by gastric acid and digestive juice, and increase the utilization rate of the drug; it can also directly remove the intestinal cavity and intestinal mucosa Toxic metabolites and toxins in the body, adjust the intestinal flora, and prevent toxic substances from entering the liver through the enterohepatic circulation, which can effectively relieve the clinical symptoms and signs of patients, reduce liver function and blood lipid indicators, improve intestinal flora, and effectively prevent and treat non-alcoholic Steatohepatitis. In addition, the traditional Chinese medicine enema of the present invention can be used alone or in combination with other medicines and treatment methods.

The invention discloses traditional Chinese medicine fructus sophorae suppository for treating the hemorrhoid hematochezia, which is prepared by mixing 650-900 parts of suppository base with alcohol extracts as medicinal active ingredients, wherein the alcohol extracts are prepared from stir-baked fructus sophorae, charred radix sanguisorbae, baikal skullcap root, stir-baked fruit of trifoliate orange, angelica and divaricate saposhnikovia root. The fructus sophorae suppository disclosed by the invention is modern novel traditional Chinese medicine preparation prepared by the prescription of the traditional fructus sophorae pill preparation, and has the effects of clearing intestine and dispelling wind, and dispelling heat from blood and stopping bleeding. The traditional Chinese medicinefructus sophorae suppository has local functions, mainly has the effects of lubrication, antibiosis, inflammation diminishing, itching relieving and the like and is convenient to use, nonirritant, easy to be accepted by sufferers. In addition, the traditional Chinese medicine fructus sophorae suppository can be further absorbed by chamber mucous membranes to join the blood circulation so as to realize the general action, such as analgesia, stimulation and the like; furthermore, the traditional Chinese medicine fructus sophorae suppository can not be subjected to enterohepatic circulation, thefirst pass effect of medicines is avoided, and the toxic or side effect of the medicines on the liver is also avoided.

The invention relates to an internal lead removal oral preparation, in particular to a weakly agglomerated carbonate powdery oral preparation and an administration method thereof. A main component of the oral preparation is carbonate capable of performing precipitation and displacement reaction with lead ions. After the preparation is swallowed, nanometer calcium carbonate is distributed on the endomembrane of the intestine, precipitation and displacement reaction is performed on calcium ions and the lead ions to generate lead carbonate with low water solubility to block the lead ions from being recovered by means of enterohepatic circulation, and the lead carbonate is excreted along with feces in the intestinal tract. According to the oral preparation, a lead removal medicament or a lead removal healthcare product is prepared from the calcium carbonate, is free of obvious toxic or side effects on a human body, and has a good dispersion effect and a good lead removal effect.

The invention relates to sauchinone sulfonate or sauchinone and geniposide (or jasminoidin) composition and application thereof in preparing liver protection medicine or senile dementia medicine. The sauchinone or geniposide has the problems of poor absorption, quick elimination, low enterohepatic circulation and bioavailability and the like when being independently applied to pharmacological activity of protecting liver or treating senile dementia; thus, sauchinone sulfonate or sauchinone and geniposide are pharmacologically combined and applied; the problems that the sauchinone and the geniposide have poor curative effects when being independently applied are solved; the sauchinone sulfonate or sauchinone and geniposide composition has an accurate curative effect and a small side effect, especially sodium sauchinone sulfonate and geniposide injection has a very accurate curative effect for treating hepatitis or liver damage or senile dementia, and the sodium sauchinone sulfonate or sauchinone and geniposide composition can be applied to intravenous administration.

The invention discloses a mangiferin cholic acid derivative, its preparation method and application, and discloses its chemical structure and chemical synthesis method. The mangiferin derivatives prepared by the present invention have liver-targeting properties, and can be targetedly accumulated in the liver and gallbladder through the enterohepatic circulation mechanism of cholic acid, thereby increasing the drug concentration and improving the ability of the mangiferin cholic acid derivatives to inhibit hepatobiliary inflammation. Effect.