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Pharmaceutical composition for treating piles as well as preparation method and application thereof

A technology of composition and medicine, which is applied in the field of medicine, can solve the problems of increasing the pain of patients and slow onset of oral medicine, etc., and achieve the effect of remarkable curative effect, rapid onset of effect and simple operation

Active Publication Date: 2012-07-18
BEIJING RECTUM HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are many ways to treat hemorrhoids. The traditional treatments mostly use surgery, drug injection, ligation, laser, radio frequency, freezing, etc., but the onset of oral medicine is slow, and surgery and other methods increase the pain of the patient. It can be seen that the existing technology needs further improvement improvement and development of

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: the suppository for treating hemorrhoids

[0027] 1. Prescription: 105g of berberine hydrochloride, 10g of procaine hydrochloride, 2.0g of hydrocortisone, 10g of borneol, 5g of menthol, and 1000g of glycerin gelatin.

[0028] 2. Preparation method

[0029] The coarse powder raw materials of berberine hydrochloride, procaine hydrochloride, borneol, and menthol in the above-mentioned prescription amount are respectively pulverized into fine powders for later use. The fine powders are passed through a 300-mesh sieve, and the matrix is ​​melted at 55°C. Add the above pulverized fine powder and weighed hydrocortisone according to the proportion of the prescription, stir and mix evenly, pour into the barrel of the suppository production equipment, and cool, the cooling temperature is controlled at 12°C to get ready.

Embodiment 2

[0030] Embodiment 2: the suppository for treating hemorrhoids

[0031] 1. Prescription: berberine hydrochloride 80g, procaine hydrochloride 6g, hydrocortisone 1.5g, borneol 7g, menthol 3.5g, semi-synthetic fatty acid ester to make up to 1000g.

[0032] 2. Preparation method

[0033] Grind the coarse powder raw materials of berberine hydrochloride, procaine hydrochloride, borneol, and menthol into fine powders for subsequent use. The fine powders are passed through a 40-mesh sieve, and the matrix is ​​melted at 50°C. Add the above-mentioned pulverized fine powder and weighed hydrocortisone according to the prescription ratio, stir and mix evenly, pour into the barrel of suppository production equipment, and cool, and the cooling temperature is controlled at 10°C to get ready.

Embodiment 3

[0034] Embodiment 3: the suppository for treating hemorrhoid

[0035] 1. Prescription: berberine hydrochloride 120g, procaine hydrochloride 20g, hydrocortisone 4.2g, borneol 18g, menthol 6.5g, and semi-synthetic fatty acid ester to make up to 1000g. .

[0036] 2. Preparation method

[0037] Grind the coarse powder raw materials of berberine hydrochloride, procaine hydrochloride, borneol, and menthol into fine powders for subsequent use. The fine powders are passed through a 400-mesh sieve, and the matrix is ​​melted at 60°C. Add the above pulverized fine powder and weighed hydrocortisone according to the proportion of the prescription, stir and mix evenly, pour into the barrel of the suppository production equipment, and cool, and the cooling temperature is controlled at 15°C to get ready.

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Abstract

The invention provides a pharmaceutical composition for treating piles, which is a suppository. The invention also provides a preparation method and application of the pharmaceutical composition. The pharmaceutical composition is prepared from the following components in parts by weight: 80-120 parts of berberine hydrochloride, 7-20 parts of procaine hydrochloride, 1.5-4.2 parts of hydrocortisone, 7-18 parts of borneol, 3.5-6.5 parts of menthol and 1000 parts of fat-soluble matrix. The pharmaceutical composition can directly reach piles infected part through rectal administration, thus the side effect of enterohepatic circulation due to oral administration is reduced. The pharmaceutical composition for treating piles provided by the invention can be used for solving the defect that oral administration is slow in acting for diseases in intestine, can substitute for the traditional operative treatment, is convenient to use and does not damage organisms.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a pharmaceutical composition for treating hemorrhoids, a preparation method and application thereof. Background technique [0002] Hemorrhoids are a chronic disease of one or more soft venous masses formed by varicose venous plexuses at the bottom of the anorectum and the anal mucosa. Usually, when defecation continues to exert force, the pressure in the vein here will rise repeatedly, and the vein will swell. During pregnancy, women often suffer from hemorrhoids due to the compression of pelvic veins, hindering blood circulation, and many obese people also suffer from hemorrhoids. If you have hemorrhoids, the walls of the swollen, twisted veins in the anus become so thin that they rupture easily during bowel movements. Internal hemorrhoids are hemorrhoids that grow at the beginning of the anal canal. If the swollen veins are located further down, almost on the opening of the anal canal, ...

Claims

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Application Information

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IPC IPC(8): A61K36/534A61K31/573A61P9/14A61K31/045A61K31/245A61K31/4375
Inventor 白蕊卢克捷张秀孙冰师桂英何金哲
Owner BEIJING RECTUM HOSPITAL
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