Bile acid modified oral granule

Abstract

The invention belongs to the technical field of biological medicine, and particularly relates to an oral surface modification bile acid granule, composition of entrapped treatment medicine in the granule and a preparation method. Firstly, a positively charged compound of entrapped treatment medicine is prepared; then, a bile acid polymer with negative ions is used for coupling to form granules. Abile acid-phospholipid compound is inserted into a wrapped granule surface to form the bile acid modified granule. The medicine wrapped granule can be lipidosome, micelle, emulsion, microspheres, nanometer particles and the like. After the granule is orally taken in the body, the granule is selectively absorbed into blood in the intestinal tract under the effect of enterohepatic circulation; the bioavailability of oral medicine can be improved. The medicine is prepared from gene, protein, polypeptide, antibodies, nucleic acid, viruses and small molecule medicine.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and clarifies an oral therapeutic composition of bile acid modified on the surface of particles. These compositions include cationic complexes and bile acid-containing anionic complexes that are coupled by electrostatic interactions to form particles. The granules contain drugs and modify bile acids. Alternatively, bile acid-phospholipid complexes are inserted into the surface of the encapsulated particles to form bile acid-modified particles. The drug-encapsulated particles can be liposomes, micelles, emulsions, microspheres, nanoparticles, etc. These compositions contain therapeutic drugs such as genes, proteins, polypeptides, antibodies, and small molecule drugs. Background technique [0002] Many therapeutic drugs are limited by various factors after oral administration, including poor intestinal permeability, resulting in low bioavailability, instability to pH or temperature leading t...

AI Technical Summary

Problems solved by technology

[0002] Many therapeutic drugs are limited by various factors after oral administration, including poor intestinal permeability, resulting in low bioavailability, unstable pH or temperature leading to drug decomposition, and some drugs are degraded by proteases, etc. Oral administration

Some chronic treatment drugs such as diabetes drugs, anticancer drugs, neuropathy and other drugs need to be taken orally for a long time. If they are made into injections, it will bring many side effects and inconvenience

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