41 results about "Taurocholic acid" patented technology

Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.

Thiepine apical sodium co-dependent bile acid transport (ASBT) inhibitors are disclosed together with methods of making the same, methods of using the same to treat hyperlipidemic conditions as well as pharmaceutical compositions containing the same compounds.

Mono-flourinated and di-fluorinated benzothiepine apical sodium co-dependent bile acid transport (ASBT) inhibitors are disclosed together with methods of making the same, methods of using the same to treat hyperlipidemic conditions as well as pharmaceutical compositions containing the same compounds.

The invention discloses a kit. The kit comprises a reagent R1 and a reagent R2, the reagent R1 contains a trihydroxymethyl aminomethane (Tris-HCL) buffer solution, an anti-taurine antibody, an anti-glycocholic acid antibody and glucose-6-phosphate (G6P), and the reagent R2 contains the trihydroxymethyl aminomethane (Tris-HCL) buffer solution, a glycocholic acid-G-6-PD conjugate, NADP and BSA. The invention further discloses a preparation method of the kit, particularly discloses a preparation method of the anti-taurine antibody the anti-glycocholic acid antibody and further discloses a method for detecting peripheral blood glycocholic acid through the kit. Accordingly, interference of taurocholic acid can be avoided, the detection sensitivity reaches up to 0.1 microgram per milliliter, and the advantages of high specificity and detection repeatability, good stability and the like are achieved.

The invention belongs to the technical field of pharmaceutical preparation and particularly relates to an oral curcumin nano-granule and a preparation method thereof. The nano-granule is prepared by self-assembling a ternary conjugated compound which is obtained by connecting taurocholic acid, heparin and curcumin through amido bonds, the curcumin is a core of the nano-granule, and the hydrophilic taurocholic acid is on the surface of the nano-granule. The oral curcumin nano-granule overcomes the poor water solubility of curcumin, the absorption of the nano-granule can be enhanced by utilizing the interaction of taurocholic acid and bile acid transporter of small intestine, the defect that the bioavailability of the oral curcumin is low can be overcome, and the heparin also has anti-thrombosis and anti-angiogenesis effect.

The invention relates to a specific adsorbing material for removing hepatitis B virus protein in blood plasma, and a preparation method of the adsorbing material, and discloses a high polymer material which is prepared by coupling sepharose gel with gene-modified sodion taurocholic acid cotransporting polypeptide. The preparation method of the material comprises the steps of reacting the sepharose gel, which is taken as a carrier matrix, with a bi-glycidyl ether coupling reagent to obtain an active carrier, and subsequently, conducting coupling reaction on the active carrier with the sodion taurocholic acid cotransporting polypeptide which is fused with polypeptide tags. The synthesis method of the material is simple and convenient, the process route is short and the preparation is safe; and the material has the characteristics of strong specificity, high adsorption rate to the hepatitis B virus protein, good regenerability, harmlessness and no heat source reaction, and can be applied to clinical adsorption treatment to eliminate the hepatitis B virus protein in blood plasma in a specificity mode.

The invention discloses a synthetic method of taurocholic acid. The method comprises the following steps: A, mixing and stirring cholic acid with acetone and cooling to -10 to 30 DEG C, adding organic alkali, dripping ethyl chloroformate below 30 DEG C after evenly stirring, reacting for 1-3 hours after dripping is finished, and filtering to obtain filtrate; B, adding the filtrate in the step A to a solution formed by taurine and water, adjusting the pH to 7-11 by using organic alkali, then reacting at 20-30 DEG C for 3-5 hours, and filtering to obtain filtrate after reaction is finished; C, adjusting the pH of the filtrate in the step B to below 1 by using 10-30% of hydrochloric acid, concentrating in vacuum at 40-65 DEG C to dry, adding methanol, heating for dissolving, adding acetone to evenly stir, and cooling to -5 to 0 DEG C for crystallizing; filtering after crystallization is finished; washing a filter cake by acetone, draining and drying in vacuum. The invention aims at providing the synthetic method of taurocholic acid, which is simple in technology, relatively low in production cost, high in yield of taurocholic acid, and convenient for industrial production.

The invention provides a composition comprising an inhibitor of Na+-taurocholate cotransporting polypeptide (NTCP) and a active ingredient selected from the group consisting of a nucleoside analogue such as lamivudine, telbivudine, or entecavir, a nucleotide analogue such as tenofovir, adefovir and an immunomodulator such as interferon alpha. The NTCP inhibitor inhibits HBV / HDV entry into a cell and is preferably derived from an HBV pre-S1 peptide. Also provided are methods of treating HBV and HDV infection, hepatitis B and D, or chronic hepatitis B and D.