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Antitumor traditional Chinese medicinal composition and antitumor active component composition, and use and preparation thereof

A technology of active ingredients and compositions, applied in the field of traditional Chinese medicine compositions, can solve the problems of unclear drug effect mechanism, difficult quality control, unclear prescriptions, etc., and achieve the effect of low price, accurate dosage, and clear ingredients

Inactive Publication Date: 2018-09-21
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is: to overcome the technical problems of the existing traditional Chinese medicine compound prescriptions of notoginseng, bezoar, musk, and snake gallbladder, such as unclear prescription, high price, complicated components, difficult quality control, unclear drug effect mechanism, etc., to provide a Inexpensive, clear ingredients, clear mechanism, accurate dosage, safe and effective anti-tumor traditional Chinese medicine composition, active ingredient composition and its use and preparation

Method used

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  • Antitumor traditional Chinese medicinal composition and antitumor active component composition, and use and preparation thereof
  • Antitumor traditional Chinese medicinal composition and antitumor active component composition, and use and preparation thereof
  • Antitumor traditional Chinese medicinal composition and antitumor active component composition, and use and preparation thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1. Screening of anti-tumor effects of different compatibility ratios of "Sanqi, artificial bezoar, artificial musk, snake gallbladder" compound

[0031] 1 Materials and methods

[0032] 1.1 Experimental materials

[0033] 1.1.1 Instruments

[0034] American Baker ultra-clean bench; Shanghai Feige KA-1000 centrifuge; Shanghai Yuejin electric heating constant temperature water bath; American Sartorius electronic balance; German Epp pipette.

[0035] 1.1.2 Experimental drugs

[0036] Notoginseng fine powder (passed through 80 mesh sieve), artificial bezoar fine powder (passed through 80 mesh sieve), artificial musk (passed through 80 mesh sieve), snake gall (passed through 80 mesh sieve), all conform to the 2015 edition of Chinese Pharmacopoeia and corresponding medicinal material standards various requirements. Cisplatin was purchased from Jiangsu Hansoh Medicine Co., Ltd. (30 mg / bottle, batch number: 170922).

[0037] 1.1.3 Cell lines and experimental animals

[00...

Embodiment 2

[0230] Preparation of preparation prescription: take 45g of Panax notoginseng, 10g of artificial bezoar, and 5g of snake gallbladder, grind them into fine powder, mix them with 5g of artificial musk, add appropriate amount of starch, magnesium stearate, microcrystalline cellulose, hydroxypropyl cellulose and other medicinal Excipients are mixed, granulated and tabletted according to the standard process to make 1000 tablets.

Embodiment 3

[0232] Preparation of formulation prescription: take 30g of Panax notoginseng, 5g of artificial bezoar, and 1g of snake gallbladder, grind them into fine powder, mix them with 1g of artificial musk, add appropriate amount of pharmaceutical excipients such as starch, lactose, sodium carboxymethyl cellulose, and mix according to the standard process , Granulating, and packing capsules to make 1000 capsules.

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Abstract

The invention relates to a traditional Chinese medicinal composition, and concretely relates to an antitumor traditional Chinese medicinal composition and an antitumor active component composition, and a use and a preparation thereof. The antitumor traditional Chinese medicinal composition comprises, by weight, 30-60 parts of Panax Notoginseng, 5-15 parts of artificial bezoar, 1-8 parts of artificial musk and 1-10 parts of snake galls. The antitumor active component composition comprises, by weight, 10-30 parts of Panax notoginseng saponins, 1-8 parts of cholic acid, 0.1-1 part of musk ketoneand 0.1-1 part of taurocholic acid. The traditional Chinese medicinal composition or the active component composition has the advantages of low price, clear components, clear mechanism, accurate dosage, safety and effectiveness, and is used for preventing or treating various malignant tumors.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to an anti-tumor traditional Chinese medicine composition, an active ingredient composition and its use and preparation. Background technique [0002] Malignant tumor is a major disease that seriously endangers human health in the world. With the change of human life style and the aggravation of environmental pollution, the incidence of malignant tumor is increasing year by year worldwide. Modern medicine has different treatment methods for various malignant tumors, but generally speaking, the treatment lacks effective methods, especially for advanced malignant tumors that cannot be surgically removed, the effective rate and cure rate are unsatisfactory. Traditional medicine in my country has accumulated rich experience in the prevention and treatment of various tumors. Because of its multi-component, multi-link, and multi-target overall action characteristics, it can si...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K35/413A61K35/55A61K35/583A61P35/00A61K31/575A61K31/122
CPCA61K31/122A61K31/575A61K35/413A61K35/55A61K35/583A61K36/258A61P35/00A61K2300/00
Inventor 黄鸣清许文
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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