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Production process of Niuchan granules with good palatability

A technology with good palatability and production process, which can be applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, allergic diseases, etc. Stability, Avoidance of Oxidation, Reduced Effects on Taste

Inactive Publication Date: 2018-04-20
广西普大动物保健品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the main ingredient in Niu Toad Granules is numb tongue, borneol is irritating to a certain extent, and bile acid in artificial bezoar is bitter. Therefore, according to the traditional production process of Niu Toad Granules, Niu Chan Granules are made by mixing materials or drinking water. Preparations, due to the above-mentioned defects in palatability, are sensitive to the taste of pigs, and the therapeutic effect on livestock with picky tastes will be affected

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] A production process of Niu Chan granules with good palatability: take toad venom, bezoar, borneol and other corresponding Chinese medicinal materials for auxiliary treatment, pulverize and process them into 50-70 mesh medicinal powder; mix the medicinal powder with 95% ethanol solution, and Extract for 3 hours, repeat suction filtration 3 times, combine the filtrate, distill under reduced pressure, evaporate ethanol, and concentrate on a vacuum rotator to make a clear paste with a relative density of 1.18-1.25; mix the clear paste with β-cyclodextrin Stir after the saturated aqueous solution is mixed evenly, after refrigeration, filtration, and drying, the clathrate of β-cyclodextrin obtained and betaine, fishy fragrance, and sodium glutamate are mixed evenly according to the mass ratio of 97:1.5:1:0.5 , adding the required auxiliary materials to make the water-soluble bull toad granules for the treatment of porcine respiratory diseases as the test drug. At the same ti...

Embodiment 2

[0011] A production process of Niu Chan granules with good palatability: take toad venom, bezoar, borneol and other corresponding Chinese medicinal materials for auxiliary treatment, pulverize and process them into 50-70 mesh medicinal powder; mix the medicinal powder with 95% ethanol solution, and Extract for 3 hours, repeat suction filtration 3 times, combine the filtrate, distill under reduced pressure, evaporate ethanol, and concentrate on a vacuum rotator to make a clear paste with a relative density of 1.18-1.25; mix the clear paste with β-cyclodextrin Stir after the saturated aqueous solution is mixed evenly, after refrigeration, filtration, and drying, the clathrate of β-cyclodextrin obtained and betaine, fishy fragrance, and sodium glutamate are mixed evenly according to the mass ratio of 97:1.5:1:0.5 , adding the required auxiliary materials to make it into a mixture for the treatment of porcine respiratory diseases. Niutoad granules are used as the test drug. At the...

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Abstract

The invention discloses a production process of Niuchan granules with good palatability. According to the present invention, at the clear paste preparation stage during Niuchan granule production, a clear paste and a beta-cyclodextrin saturated aqueous solution are uniformly mixed and stirred, cold preservation, filtration and drying are performed to obtain a beta-cyclodextrin inclusion compound,the beta-cyclodextrin inclusion compound, betaine, fishy attractant and sodium glutamate are uniformly mixed according to a mass ratio of 97:1.5:1:0.5, and a required auxiliary is added to prepare theNiuchan granules; by using the molecular coating technology, taurocholic acid affecting the palatability, venenum bufonis and borneol are coated with beta-cyclodextrin while the flavoring agent is added, such that the poor taste of the Niuchan granules is significantly reduced; with the application of the molecular coating technology to prepare the Niuchan granules, the stability of the drug is increased, and the adverse effects of the oxidation effect, the temperature, the pH value and other factors on the effective components are avoided; and the production process is suitable for the veterinary dosage forms of known Niuchan granules with different treatment purposes and different use methods.

Description

technical field [0001] The invention relates to the technical field of production of animal health products, in particular to the technical field of production of traditional Chinese medicine preparations in the extraction process of veterinary drugs. Background technique [0002] As a veterinary preparation, Niuchan Granules was officially included in the third volume of "Compilation of National Standards for Veterinary Drugs" in 2012. The main component of Butoad granules, toad venom, has significant anti-virus, antibacterial and anti-inflammatory effects, and enhances the body’s immunity, and has the characteristics of low toxicity, high efficiency, and no residue. Therefore, Veterinary Bull toad Granules are widely used in the production process of livestock and poultry . However, the main ingredient in Niu Toad Granules is numb tongue, borneol is irritating to a certain extent, and bile acid in artificial bezoar is bitter. Therefore, according to the traditional produc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/65A61K9/16A61K47/69A61P29/00A61P31/12A61P37/04A61K35/413A61K31/045
CPCA61K35/65A61K9/1617A61K31/045A61K35/413A61K2300/00
Inventor 严明周艳海韦励平胡庭俊严寒葛洪伟侯太乾葛闻梁先武
Owner 广西普大动物保健品有限公司
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