The invention provides a rapidly-dissolving mosapride citrate composition, which comprises mosapride citrate and fumed silica. Mosapride citrate and fumed silica are mixed and crushed in a crushing machine, wherein mass ratio of mosapride citrate to fumed silica is 1:0.2-1.2; and particle size D50 of the mosapride citrate is less than or equal to 3.0 microns. The composition also contains one or more ingredients selected from a filler, a disintegrating agent, an adhesive, a lubricant, a flow aid and a flavouring agent. By the use of the mosapride citrate composition, dissolution rate of mosapride citrate in a buffer solution (a simulated intestinal fluid) with pH 6.8 is greatly raised, and medication effectiveness is raised for achlorhydria patients. The preparation technology is simple and is easy to operate. Any organic reagents are not used, and hot and humid process is not required. Instability of mosapride citrate in a hot and humid environment is avoided. The composition of the invention is suitable for industrial production.