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57 results about "Large intestinal" patented technology

Probiotic/Non-Probiotic Combinations

This invention pertains to a method of promoting gastrointestinal health by ingesting a composition comprising one or more probiotic microorganisms, one or more carbohydrate sources, and one or more resistant protein products. Large intestinal health is benefited by one or more of the following: increased fecal weight, lower fecal pH, increased carbohydrate fermentation, and amelioration of protein fermentation.
Owner:BRUNOB II BV

Formulations for alteration of biophysical properties of mucosal lining

InactiveCN101237853AReduce disseminationReduce surrounding pollutionAntibacterial agentsOrganic active ingredientsActive agentIn vivo
The inventors have developed conductive formulations and methods of use thereof containing conductive agents that are ionic or readily ionizable in aqueous or organic solvent environments, such as salts, ionic surfactants, or other substances. The formulation may optionally contain one or more active agents, eg, antiviral, antimicrobial, anti-inflammatory proteins or peptides. The active agent can be co-administered or incorporated into the formulation, or can be administered after administration of the conductive formulation. When applied to a mucosal lining fluid, the formulation alters the physical properties of the mucosal lining, such as surface tension, surface elasticity, and bulk viscosity. The formulations are administered in amounts sufficient to alter the biophysical properties of the mucosal lining in vivo. The formulation can be administered for several different purposes: to reduce the spread of viral and bacterial infectious diseases such as SARS, influenza, tuberculosis, and RSV in humans, and foot-and-mouth disease in artiodactyls; Ambient pollution caused by particle formation when sneezing or talking is particularly important in the use of clean rooms; reducing or preventing the occurrence of obstructive sleep apnea and some cases of irritable bowel syndrome; and controlling the intake of drug molecules and pathogens into the dynamics.
Owner:PULMATRIX

Composition of koji of rice bran and non-propagating lactic acid bacteria

In view of the finding that keeping a healthy body is fundamental for overcoming cancer, it is an object of the present invention to provide a nutritious composition that is effective in suppressing mutagenic substances and promoting good health. The composition also suppresses large intestinal cancer. The composition includes dietary fiber in a range of 15 wt % to 30 wt % in respect to the total amount of composition which is contained in dried koji fine powder that includes dead fungi of Aspergillus and active enzyme produced by the Aspergillus.
Owner:GENMAI KOSO

Method for producing food with fruit and vegetable fiber and kelp powder

The invention relates to a process for preparing the vegetable and fruit alginate fiber, which is a food addictive with low-energy and high-fiber and made of potato starch (food fiber) with resistant property (RS2)which is hardly digestive and adsorptive, bean slag fiber, apple slag fiber, wheat bran fiber, mushroom fiber and sea weed powder. Treating the starch, bean slag, apple slag, wheat bran, mushroom and sea weed with acid and base, modifying the starch to make it be resistant, removing sugar (starch) and protein from the food slag to make them become the food fiber, then breaking, drying and sterilizing and getting the product. The product can be directly added into the gruel, milk and vegetable soup with noodle; or can be used as seed powder of Gorgon euryale to add into the fried dish and vegetable soup; and can be added into the bread and pot food. The product can increase the dung capacity after eaten and thus for bowel relaxing, the fiber expands when meets with water and to curb the increasing tendency of the overweight, fatty, coronary disease, large intestinal cancer for the reason of taking in too much refined food and energy.
Owner:刘国柱

In vitro gastrointestinal model comprising lamina propria-derived cells

An in vitro microfluidic gut-on-chip is described herein that mimics the structure and at least one function of specific areas of the gastrointestinal system in vivo. In particular, a multicellular, layered, microfluidic culture is described, allowing for interactions between lamina propria-derived cells and gastrointestinal epithelial cells and endothelial cells. This in vitro microfluidic system can be used for modeling inflammatory gastrointestinal tissue, e.g., Crohn's disease, colitis and other inflammatory gastrointestinal disorders. These multicellular, layered microfluidic gut-on-chip further allow for comparisons between types of gastrointestinal tissues, e.g., small intestinal deuodejeum, small intestinal ileium, large intestinal colon, etc., and between disease states of gastrointestinal tissue, i.e. healthy, pre-disease and diseased areas. Additionally, these microfluidic gut-on-chips allow identification of cells and cellular derived factors driving disease states and drug testing for reducing inflammation.
Owner:EMULATE INC

Method to expand and transduce cultured human small and large intestinal stem cells

A cell culture media composition for support growth of human SI stem cells and epithelium without a feeder layer is presented. The media may also include growth factors including ENR and Y-27632 that support the survival of stem cell spheroid structures. The cell culture media compositions permit rapid growth of human small intestinal (SI) epithelium and stem cells, which leads to specific spheroid cell and enteroid morphology when grown in 3-D culture system.
Owner:RGT UNIV OF CALIFORNIA +1

Medicinal composition for preventing and curing stomach and intestine tumor through epigenetic modification

The present invention belongs to the field of medicine technology, and is especially one kind of medicine composition for regulating apparent genetic modification to prevent and treat gastrointestinal tumor. The medicine composition consists of effective components folic acid and sodium butyrate, medicine carrier and excipient. Experiments show that the medicine composition of the present invention can affect the methylation and acetylation of apparent genetic modification DNA, and further affect the gene expression of cell line of gastric cancer and / or large intestinal cancer or even change the cell period and inhibit tumor growth. The present invention has obvious tumor preventing and treating effect, no obvious toxic side effect and low cost.
Owner:房静远 +2

Program-controlled pig bionic digestion system and method using program-controlled pig bionic digestion system to quickly determining digestible energy value of pig feed

The invention discloses a program-controlled pig bionic digestion system and a method using the program-controlled pig bionic digestion system to quickly determining a digestible energy value of pig feed. The method comprises the following steps that a feed sample is pulverized and sieved through a standard sieve; a gastric buffer solution and an intestinal buffer solution are prepared; simulatedgastric juice, simulated small intestinal juice and simulated large intestinal juice are prepared; the pulverized feed sample is filled into a simulated digester of the program-controlled pig bionic digestion system, and the simulated gastric juice is added in sequence through computer program control to simulate gastric digestion; after the intestinal buffer solution is added, the simulated smallintestinal juice is added to simulate small intestinal digestion; the simulated large intestinal juice is added to simulate large intestinal digestion; inactivation is carried out after the digestionis completed; and then cleaning is carried out, after undigested residues are obtained, a total energy value of the residues and the feed sample is tested, and the digestible energy value of the feedis calculated. The method is simple, high in precision, low in implementation cost, and the digestible energy value of the pig feed can be accurately determined within 72 hours.
Owner:INST OF ANIMAL SCI OF CHINESE ACAD OF AGRI SCI

Compound traditional Chinese medicine preparation with effects of benefiting qi and activating blood circulation for preventing and treating gastric cancer, and preparation method thereof

The invention relates to a compound traditional Chinese medicine preparation with effects of benefiting qi and activating blood circulation for preventing and treating a gastric cancer, and a preparation method thereof, and belongs to the technical field of a traditional Chinese medicine preparation for preventing and treating the gastric cancer. The technical scheme is that the compound traditional Chinese medicine preparation is prepared from the following traditional Chinese medicine components by weight percent: 15-25% of glaucescent fissistigma root, 15-25% of buckwheat leaves, 15-20% of bighead atractylodes rhizome, 10-15% of curcuma zedoary, 10-15% of semen coicis and 10-15% of brucea javanica. The preparation can be prepared into capsules, tablets, powder and the like according to the requirements; the full formula has the effects of benefiting qi and activating blood circulation, and eliminating stagnation to stop pain, and can effectively relieve epigastrium pain, swelling and stuffing, and poor appetite of a patient with gastric carcinoma. The compound traditional Chinese medicine preparation acts on a plurality of organs such as spleen, stomach, large intestines and the like, fully reflects unique understanding of the traditional Chinese medicine on an overall organic body of a human body, achieves the anti-tumor target by conditioning the whole body function, is accurate in curative effect, wide in drug source, low in cost, convenient to produce and take, and significant in treatment effect on the gastric cancer.
Owner:NORTH CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Lactic acid bacteria and their cellular components inducing immunoregulatory function, and method of obtaining the same

To provide a microorganism and an ingredient thereof that contribute to prevention and treatment of immune diseases including allergy, autoimmune diseases and inflammatory bowel diseases (e.g., large-intestinal ulcer), a method of effectively selecting the microorganism, and a method of efficiently inducing immunoregulatory cells that play an important role on maintaining immunological homeostasis using the microorganism or the ingredient thereof. The present invention provides a Lactococcus and an ingredient thereof which induce production of IL-10 from mammalian dendritic or spleen cells, a method of obtaining the microorganism or the ingredient thereof by co-culturing a microorganism such as Lactococcus strains with mammalian dendritic or spleen cells to select a microbial cell having a high IL-10 production ability, a method of selecting the microorganism or the ingredient thereof by co-culturing an intestinal epithelial cell with a microorganism such as the lactic acid bacteria and selecting the cells on the basis of a caspase-1 activity and the ability of inducing the production of IL-18, and a food product or material and an animal feeding stuff or medical and pharmaceutical products which contain the lactic acid bacteria as an effective ingredient.
Owner:NAT INST OF AGROBIOLOGICAL SCI +1

Chinese medicine composition and its prepn process and quality control method

The present invention discloses one kind of Chinese medicine composition, which is prepared with skullcap root, giant knotweed, andrographis herb, Chinese mahonia and other Chinese medicinal materials in certain weight proportion, and through certain technological process. The Chinese medicine composition may be prepared into different preparation forms, tablet, capsule, granule, etc. The Chinese medicine composition has excellent curative effect on swelling and sore throat, boil of lips and tongue, common cold, fever, large intestinal damp-heat diarrhea and other diseases. The present invention also discloses the preparation process and quality control method of the Chinese medicine composition.
Owner:吴逸芳

Nano-drug carrier wrapped by bacterial outer membrane vesicles and preparation method of nano-drug carrier

The invention relates to a nano-drug carrier wrapped by bacterial outer membrane vesicles and a preparation method of the nano-drug carrier. The carrier adopts outer membrane vesicles secreted by Escherichia coli to wrap polydopamine modified doxorubicin-loaded mesoporous silica nanoparticles, and the preparation method comprises the following steps: preparing the doxorubicin-loaded mesoporous silica nanoparticles, modifying the doxorubicin-loaded mesoporous silica nanoparticles by polydopamine, and extracting and purifying the outer membrane vesicles of bacteria. And preparing the nano-drug carrier OMVs-NPs wrapped by the outer membrane vesicles of the bacteria. The prepared OMVs-NPs can prevent the medicine from being released too early in a biological environment, outer membrane vesicles secreted by Escherichia coli have an adsorption effect on intestinal tracts, the OMVs-NPs serve as a biological outer membrane of a novel nano preparation, intestinal absorption of medicine carrying nanoparticles can be improved, the medicine is released after tumor cells are targeted, and the bioavailability of the medicine is improved.
Owner:LIAONING UNIVERSITY

Colorectal cancer biomarker as well as screening method and application thereof

The invention relates to a colorectal cancer biomarker as well as a screening method and application thereof, and belongs to the technical field of cancer diagnosis. The colorectal cancer biomarker provided by the invention comprises human intestinal microorganisms and / or fecal human target genes; the intestinal microorganisms of the human body comprise one or more than two of Brawtella, Pseudomonas 9, Fecal bacillus, fusiform, Wehonor coccus, Escherichia coli-Shigella, Mycobacterium, Fusobacterium, Porphyrinium, peptostreptococcus and Bacteroides; the fecal human body target spot gene comprises ADHFE1 and / or SDC2. The biomarker combination disclosed by the invention is high in sensitivity and good in specificity, and has a profound prospect for estimating the risk of colorectal cancer. According to the invention, a data model is established through the biomarker, and the model can be used for evaluating the risk of colorectal cancer.
Owner:广西爱生生命科技有限公司

Pharmaceutical composition for treating large intestinal cancer

The invention discloses a drug composite for curing colorectal cancer. The drug composite is composed of 5-N deoxycytidine and rapamycin. The weight proportion of the 5-N deoxycytidine and the rapamycin is 66.7:1-249.6:1. Compared with the use of the 5-N deoxycytidine and the rapamycin separately for the treatment of the colorectal cancer, the invention can obviously inhibit the growth of human colorectal cancer cells and can significantly reduce the incidence rate and tumor size of colorectal cancer in rats.
Owner:RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

Drug for diagnosing large intestinal cancer and/or polyp, observing postoperative course and monitoring recurrence

The present invention is directed to a method for diagnosing large intestinal cancer and / or polyp and a method for observing postoperative course or monitoring recurrence thereof, wherein each method includes detecting cystatin SN protein by use of an anti-cystatin SN antibody. The present invention is able to provide a kit for assaying cystatin SN, which can be used, in a simple manner, in a diagnosis performed prior to conventional barium enema examination and endoscopic examination which impose burdens on patients; as an indicator of metastasis and recurrence; and in the evaluation of therapeutic effects. The present invention provides a method for diagnosing or monitoring large intestinal cancer and / or polyp which can be performed in a simple manner, and thus can allow to design a new regimen rapidly.
Owner:PERSEUS PROTEOMICS INC +1

Traditional Chinese medicine composition and traditional Chinese medicine preparation for preventing relapse of postoperative intestinal polyp

The invention discloses a traditional Chinese medicine composition for preventing relapse of postoperative intestinal polyp, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises 12 to 18 parts of Ramulus Cinnamomi, 12 to 18 parts of poria cocos, 7 to 13 parts of cortex moutan, 7 to 13 parts of fried peach kernels, 15 to 25 parts of radix paeoniae rubra, 3 to 5 parts of rhizoma coptidis, 12 to 18 parts of spina gleditsiae, 12 to 18 parts of sargentg loryvine stem, 12 to 18 parts of radix actinidiae chinensis and 12 to 18 parts of fried semen coicis. The traditional Chinese medicine composition can prevent relapse of the polyp and adjust or reverse the overall morbidity factor of a patient, so that the healthy constitution of the patient is recovered, and the disease resistance is enhanced; and clinical observation shows that the traditional Chinese medicine composition can relieve symptoms and prevent relapse after being taken after a colorectal polyp operation, is remarkable in curative effect and free of obvious side effects, and has good clinical application value.
Owner:陕西中医药大学附属医院

Pediococcus pentosaceus derived from breast milk and application of pediococcus pentosaceus

ActiveCN111793586AHas broad-spectrum antibacterial activityConducive to maintaining micro-ecological balanceAntibacterial agentsMilk preparationBiotechnologyDisease
The invention belongs to the field of microbial fermentation, and particularly relates to pediococcus pentosaceus derived from breast milk and application of the pediococcus pentosaceus. The pediococcus pentosaceus derived from the breast milk is pediococcus pentosaceus HM75-1 and is preserved in the China Center for Type Culture Collection on October 22, 2019, and the preservation number of the pediococcus pentosaceus is CCTCC NO: M 2019849. The strain is high in bacteriostatic ability, has relatively high inhibitory activity on common pathogenic bacteria in intestinal tracts, and particularly has a remarkable inhibitory effect on enterotoxigenic escherichia coli; the strain is good in gastrointestinal tolerance and high in adaptability to gastrointestinal tracts of human bodies, and canbe finally used for preparing medicines for inhibiting pathogenic bacteria of intestinal tracts and preventing and treating food-borne diseases, infant milk powder supplements, food preservatives andthe like.
Owner:SHIHEZI UNIVERSITY

In vitro gastrointestinal model comprising lamina propria-derived cells

An in vitro microfluidic gut-on-chip is described herein that mimics the structure and at least one function of specific areas of the gastrointestinal system in vivo. In particular, a multicellular, layered, microfluidic culture is described, allowing for interactions between lamina propria-derived cells and gastrointestinal epithelial cells and endothelial cells. This in vitro microfluidic system can be used for modeling inflammatory gastrointestinal tissue, e.g., Crohn's disease, colitis and other inflammatory gastrointestinal disorders. These multicellular, layered microfluidic gut-on-chip further allow for comparisons between types of gastrointestinal tissues, e.g., small intestinal deuodejeum, small intestinal ileium, large intestinal colon, etc., and between disease states of gastrointestinal tissue, i.e. healthy, pre-disease and diseased areas. Additionally, these microfluidic gut-on-chips allow identification of cells and cellular derived factors driving disease states and drug testing for reducing inflammation.
Owner:EMULATE INC

Physiology and pathophysiology of human gut: intestine-on-chip

An in vitro microfluidic intestine on-chip is described herein that mimics the structure and at least one function of specific areas of the gastrointestinal system in vivo. In particular, a multicellular, layered, microfluidic intestinal cell culture, which is some embodiments is derived from patient's enteroids-derived cells, is described comprising L cells, allowing for interactions between L cells and gastrointestinal epithelial cells, endothelial cells and immune cells. This in vitro microfluidic system can be used for modeling inflammatory gastrointestinal autoimmune tissue, e.g., diabetes, obesity, intestinal insufficiency and other inflammatory gastrointestinal disorders. These multicellular-layered microfluidic intestine on-chips further allow for comparisons between types of gastrointestinal tissues, e.g., small intestinal duodenum, small intestinal jejunum, small intestinal ileum, large intestinal colon, etc., and between disease states of gastrointestinal tissue, i.e. healthy, pre-disease and diseased areas. Additionally, these microfluidic gut-on-chips allow identification of cells and cellular derived factors driving disease states and drug testing for reducing inflammation.
Owner:EMULATE INC

Application of Chinese medicine composition in preparation of medicament for treating overhigh level of urine cell factor or receptor thereof and Escherichia coli infection

The invention relates to application of a Chinese medicine composition in preparation of a medicament for treating the overhigh level of a urine cell factor or a receptor thereof and Escherichia coli infection. The cell factor or receptor thereof is sIL-2R, IL-6 and IL-8. The Chinese medicine composition is prepared from the following raw materials in percentage by weight: 14-20 percent of cherokee rose root, 6-10 percent of chinaroot greenbrier, 7-10 percent of akebia trifoliata koidz, 3.0-6.5 percent of Japanese climbing fern and 3.2-6.8 percent of centella. The Chinese medicine composition has obvious curative effect on urinary tract infection with overhigh level of urinary sIL-2R, urinary IL-6 and urinary IL-8 and urinary tract infection and lower respiratory tract infection with Escherichia coli as a main pathogenic bacterium.
Owner:GUILIN SANJIN PHARMACEUTICALS CO LTD

Fructus-sophorae Radix et Rhizoma sanguisorbae preparation and new preparing method

The present invention relates to a Chinese medicine composition for curing hematochezia, large-intestinal heat-accumulating and hemorrhoid swelling pain. It can be made into dripping pills and soft capsule preparation.
Owner:FUKANGREN BIO PHARMA

Lactic acid bacteria and their cellular components inducing immunoregulatory function, and method of obtaining the same

To provide a microorganism and an ingredient thereof that contribute to prevention and treatment of immune diseases including allergy, autoimmune diseases and inflammatory bowel diseases (e.g., large-intestinal ulcer), a method of effectively selecting the microorganism, and a method of efficiently inducing immunoregulatory cells that play an important role on maintaining immunological homeostasis using the microorganism or the ingredient thereof. The present invention provides a Lactococcus and an ingredient thereof which induce production of IL-10 from mammalian dendritic or spleen cells, a method of obtaining the microorganism or the ingredient thereof by co-culturing a microorganism such as Lactococcus strains with mammalian dendritic or spleen cells to select a microbial cell having a high IL-10 production ability, a method of selecting the microorganism or the ingredient thereof by co-culturing an intestinal epithelial cell with a microorganism such as the lactic acid bacteria and selecting the cells on the basis of a caspase-1 activity and the ability of inducing the production of IL-18, and a food product or material and an animal feeding stuff or medical and pharmaceutical products which contain the lactic acid bacteria as an effective ingredient.
Owner:NAT INST OF AGROBIOLOGICAL SCI +1

White traditional Chinese medicine bag for treating lung disease and large intestinal disease

The invention discloses a white traditional Chinese medicine bag for treating a lung disease and a large intestinal disease, and belongs to the technical field of traditional Chinese medicines. The white traditional Chinese medicine bag is prepared from the following raw materials in parts by weight: 100 parts of folium artemisiae argyi, 5-10 parts of semen lepidii, 5-10 parts of rheum officinale, 5-10 parts of peony, 3-10 parts of liquorice (preparata), 3-10 parts of radix scutellariae, 3-10 parts of rhizoma zingiberis, 3-10 parts of radices ophiopogonis, 3-10 parts of schisandra chinesis, 3-10 parts of inula britannica chinensis, 9-10 parts of wild ginger, 6-10 parts of rehmannia glutinosa, 6-10 parts of bamboo leaves and 6-10 parts of liquorice, and the raw materials are subjected to gigging or ground into powder, mixed, fermented and pressed to form a dished medicine cake. When in use, the white traditional Chinese medicine bag is put in a traditional Chinese medicine biophysical moxibustion apparatus for moxibustion therapy on a human body; a lung system can be balanced; various diseases or symptoms resulting from a deficiency syndrome of the lung or an excess syndrome of the lung can be treated; the treatment effect is significant; no toxic or side effect exists; and the defects that insufficient burning, fire falling, ash falling, heavy smoke and a sharp taste exist in the common moxibustion therapy are overcome.
Owner:刘瑜

Application of drug composition product

The invention relates to application of drug composition product in curing diseases of the respiratory system. The effect of the drug composition product on curing the respiratory system diseases caused by infection of escherichia coli and klebsiella pneumoniae is better than the effect of the drug composition product on curing urinary system diseases caused by infection of the escherichia coli and the klebsiella pneumoniae.
Owner:麦丽芳

Acf detection method

Provided is a method for detecting aberrant crypt foci (ACF) by analyzing a region of interest in large intestinal tissue at a molecular level. That is, provided are: a method for detecting ACF using at least one molecule, the expression level of which is elevated specifically to ACF, as an ACF detection marker, and detecting the ACF detection marker in a region of interest in large intestinal tissue, wherein the at least one molecule is selected from the group consisting of Met, Cdh1, Ctnnb1 and GSTp; an ACF detection marker which is a marker for detecting ACF in human-originated large intestinal tissue and is Met, Cdh1, Ctnnb1 or GSTp; and a method for evaluating the risk of colorectal cancer and colorectal adenoma in a human body, which comprises detecting ACF in a region of interest in large intestinal tissue from a subject using the aforementioned ACF detection method and evaluating the risk of colorectal cancer and colorectal adenoma in the subject on the basis of the results of the detection.
Owner:OLYMPUS CORP
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