The invention relates to a slow-release formulation containing
sarafloxacin as antibiotic, which is slow-released injection or slow-released
implant; the injection is composed of a slow-released
microsphere and dissolvent; the slow-released
microsphere contains a slow-released
adjuvant and the antibiotic; the dissolvent is a special dissolvent containing suspending agent such as
sodium carboxymethylcellulose, etc. and the
viscosity of the dissolvent is 100cp-3000cp (at the temperature of 20 DEG C-30 DEC C); the slow-released
adjuvant is selected from EVAc, polifeprosan, PLA,
PLGA,
sebacic acid copolymer, albumen glue,
gelatin, etc.; the slow-released
implant is prepared with the slow-released
microsphere or by other methods. The slow-released
implant can be partially placed or injected in a bacterial focus to release
medicine on a partial
disease focus for more than 10 days slowly; valid
medicine concentration on the partial focus is obtained and maintained effectively, at the same time
toxicity of an entire body is remarkably reduced. The slow-release formulation containing the
sarafloxacin as the antibiotic has remarkable and special
treatment effect on infection caused by
staphylococcus,
streptococcus,
peptostreptococcus,
propionibacterium acnes,
enterobacter,
tubercle bacillus, gonococci and meningococcus, etc., and particularly the partial focus such as
chronic osteomyelitis, severe bedsore,
refractory skin ulcer,
diabetic foot,
femoral head necrosis and various abscesses, etc..