54results about How to "Promote intestinal absorption" patented technology

A composition for oral delivery of a poorly absorbed drug is disclosed. The composition includes the drug, an enhancer for increasing absorption of the drug through the intestinal mucosa, a promoter, which alone does not increase absorption of the drug through the intestinal mucosa, but which further increases the absorption of the drug in the presence of the enhancer, and optionally a protector for protecting the drug from physical or chemical decomposition or inactivation in the gastrointestinal tract. Illustrative enhancers include sucrose fatty acid esters, and illustrative promoters include aminosugars and amino acid derivatives, such as poly(amino acids). Illustrative protectors include methylcellulose, poly(vinyl alcohol), and poly(vinyl pyrrolidone).

A metformin-cysteine prodrug. It is believed that the prodrug of the present invention will transport in the LAT1 and LAT2 transporter system. Because the LAT1 and LAT2 transporters are important and effective transporters of amino acids in both the small intestine and colon, it is believed that the LAT-transportable prodrugs of the present invention will be effectively absorbed both in small intestine and in the colon. The increased absorption window provided by the present invention should result in highly sustained plasma concentrations of metformin, thereby increasing the effectiveness of the medication and allowing for a single daily dose.

The present invention provides a solid composition for oral administration comprising: (i) a drug compound; (ii) chitosan or a derivative thereof or a salt of chitosan or salt of a derivative of chitosan; and (iii) an organic acid. Preferably the drug compound is a polar molecule having a molecular weight of 1 KDa or less, a peptide, a protein or a polysaccharide. The compositions of the invention provide enhance absorption of the drug compound.

The present invention relates to a method of promoting immunoglobulin A secretion in the mucosal membranes of non-human animals. The method comprises administering a foodstuff comprising glutamine to the non-human animal.

The invention discloses a micro-ecology preparation for pig feed, and a preparation method thereof, and belongs to the technical field of the micro-ecology preparation. The micro-ecology preparation comprises the following raw materials in parts by weight: 0.5-1 part of enterococcus faecalis, 0.2-1.2 parts of lactobacillus johnsonii, 0.5-1.0 part of bacillus subtilis, 0.2-0.5 part of bacillus licheniformis, 1-1.5 parts of clostridium butyricum, 0.5-1.5 parts of lactobacillus acidophilus and 1.5-2.0 parts of clostridium butyricum. The micro-ecology preparation disclosed by the invention can obviously lower the incidence rate of live pig intestinal diseases, improves a piglet growth rate, reduces feed consumption and drug expenditure, and greatly lowers culture cost.

Described are fusion proteins of GLP-2 with an Fc region of immunoglobulin. The GLP-2 and Fc regions are separated by a linker comprised of amino acids. The fusion proteins persist and remain active in the body for longer periods of time than GLP-2 itself. Methods are disclosed of using the fusion proteins to treat and prevent enterocutaneous fistulae, radiation damage to the gastrointestinal tract, obstructive jaundice, and short bowel syndrome.

The invention discloses a preparation method of a biological feed from insect protein, which comprises the following steps: S1, selecting the following first raw materials according to a weight ratio: a strain stock solution containing a biological enzyme, first brown sugar, immune polysaccharide, Chinese herbs, composite vitamins and edible salt; S2, adding all the raw materials into water with the weight being 5-15 times that of the raw materials to form a mixed solution, and propagating the mixed solution in the environment with the temperature of 28-30 DEG C and the air humidity of 65-75% for 3-7 days; S3, selecting the following second raw materials according to the weight ratio: tenebrio molitor, hermetia illucens and barley pest, respectively collecting and separating the second raw materials, then sterilizing at high temperature, respectively grinding into pulp, and finally mixing into insect pulp; and S4, wrapping the insect pulp with a gauze bag, putting the wrapped insect pulp into the mixed solution in the step S2, adding second brown sugar, and performing fermentation in an environment with the temperature of 28-30 DEG C and the air humidity of 65-75% for 3-5 days. The preparation method of a biological feed from insect protein is applied to the technical field of biological feed.

The invention relates to a nutritional composition for infants, and in particular, relates to a nutritional composition for improving intestinal health of the infants and/or improving intestinal tolerance of the infants and/or reducing eczema of the infants, and an infant formula food. The infant nutritional composition comprises galactooligosaccharide, 1,3-dioleic acid-2-palmitic acid triglyceride, whey protein hydrolysate and other nutritional ingredients.

The present invention relates to the technical field of health-care products and particularly relates to herba dendrobii yogurt. During the preparation, the dry herba dendrobii is beat into superfine powder, the powder is mixed evenly with honey to obtain an initial material, the initial material is frozen and thawed for three times to obtain a freezing-thawing material, the freezing-thawing material and fresh milk are mixed, the mixture is poured into an empty bottle, yogurt is poured into the bottle, the yogurt is stirred rapidly until the yogurt is fully merged, the stirred yogurt is fermented, the fermented yogurt is clotted, the clotted yogurt is transferred into a refrigerator to be frozen, the frozen yogurt is inspected to be qualified, and the qualified yogurt is filled to be the herba dendrobii yogurt. The treatment method can maximally retain the active components in the herba dendrobii and the obtained herba dendrobii yogurt is stable in quality, sweet and sour, and tasty.

An object of the present invention is to provide a pharmaceutical composition that improves intestinal absorption of a compound having a structure represented by the general formula [1]. The composition containing a compound represented by the general formula [1] or a salt thereof and (b) a lipophilic substance improves intestinal absorption of the compound. In the formula, A represents —(NR⁴)—, —(CR⁵R⁶)— or the like; B represents an alkylene group or an alkenylene group; R¹ represents an alkyl group, an alkenyl group or the like; R² represents an adamantylalkyl group or the like; R³ represents an unsaturated heterocyclic ring; R⁴, R⁵ and R⁶ each represent a hydrogen atom or the like; and X represents an oxygen atom or the like.

Provided is nano-sized kimchi lactic acid bacteria, and more particularly, to Lactobacillus plantarum (L. plantarum) isolated from kimchi. The nano-sized kimchi lactic acid bacteria has an effect of inhibiting intestinal putrefactive bacteria and improving an intestinal environment through activation of an immune function, and an excellent effect of preventing and treating colorectal diseases including colitis and colorectal cancer. The nano-sized kimchi lactic acid bacteria consist of uniform particles to facilitate intestinal absorption, and an effect of improving an intestinal environment is proportionally increased according to a concentration. In addition, the nano-sized kimchi lactic acid bacteria is a food additive, which provides effects of the lactic acid bacteria without damage to natural taste and flavor of a food, and although the nano-sized kimchi lactic acid bacteria are added to a food to be heated, due to high thermal resistance, the effects are maintained.

The invention relates to a feed formula and a production technology of the feed formula, in particular to a formula of piglet feed and a production technology. The formula comprises 45-55kg corn, 45-55kg wheat, 4-6kg rice bran, 8-12kg bean cake, 0.8-1.3kg fish meal, 0.8-1.2kg bone meal, 0.3-0.5kg table salt, 0.4-0.6kg stone powder, 0.1-0.3kg copper sulfate, 0.1-0.2kg potassium sulfate, 0.01-0.03kg potassium iodate, 5000 international units of vitamin A, 500 international units of vitamin D, 20 international units of vitamin E, 10mg vitamin K, 15mg vitamin B and 10mg vitamin B2. According to the formula of the piglet feed and the production technology, the body immunity of a piglet can be improved; disease prevention and health care effects are better; an appetite of the piglet can be improved; intestinal tract absorption of the piglet is facilitated; the growth of the piglet is significantly promoted; the slaughtering weight is increased; the meat quality of a livestock product meets a pollution-free requirement; an export standard of the livestock product is met; and physical health of people is effectively ensured.