54results about How to "Promote intestinal absorption" patented technology

A composition for oral delivery of a poorly absorbed drug is disclosed. The composition includes the drug, an enhancer for increasing absorption of the drug through the intestinal mucosa, a promoter, which alone does not increase absorption of the drug through the intestinal mucosa, but which further increases the absorption of the drug in the presence of the enhancer, and optionally a protector for protecting the drug from physical or chemical decomposition or inactivation in the gastrointestinal tract. Illustrative enhancers include sucrose fatty acid esters, and illustrative promoters include aminosugars and amino acid derivatives, such as poly(amino acids). Illustrative protectors include methylcellulose, poly(vinyl alcohol), and poly(vinyl pyrrolidone).

The invention relates to relates to a method for preparing a composition containing 1,3-di-unsaturated fatty acyl-2-saturated fatty acyl glyceryl ester, particularly containing 1,3-di-oleoyl-2-palmitoyl glyceryl ester (OPO), which comprises the steps of: carrying out random ester exchange on an ester rich in saturated fatty acid residue and an ester rich in unsaturated fatty acid residue serving as reaction substrates, and carrying out enzymatic oriented ester exchange on the reaction mixture and unsaturated fatty acid or unsaturated fatty acid ester. The invention also provides application of the composition to preparing formula milk powder for infant and preparing synthetic food for infant, and the formula milk powder for infant and the synthetic food for infant containing the composition.

A method including administering a beverage composition suitable for human consumption including effective amounts of the following solubilized components, a calcium compound, an organic acid in an amount up to the equivalent amount of a calcium of the calcium compound, an isoflavone, and inulin wherein the effective amounts are sufficient to reduce the risk of bone density loss and are solubilized by a stabilizing agent including one or more of maltol, carrageenan and maltodextrin, and xanthan gum.

The present invention relates to a new composition, use and method for oral administration to a human or an animal of a physiologically active agent comprising neutralizing agents to increase pH in the digestive system to prevent denaturation, inhibitors of digestive enzymes to substantially prevent enzymatic digestion, and at least uptake increasing agents which increases intestinal absorption of a physiologically active agent, a drug and / or a nutrient.

A metformin-cysteine prodrug. It is believed that the prodrug of the present invention will transport in the LAT1 and LAT2 transporter system. Because the LAT1 and LAT2 transporters are important and effective transporters of amino acids in both the small intestine and colon, it is believed that the LAT-transportable prodrugs of the present invention will be effectively absorbed both in small intestine and in the colon. The increased absorption window provided by the present invention should result in highly sustained plasma concentrations of metformin, thereby increasing the effectiveness of the medication and allowing for a single daily dose.

A composition and a method for administering an improved supplement to prevent bone density loss. The composition combines a calcium compound with inulin, and optionally magnesium, Vitamin D3, Vitamin K, Vitamin C, and may combine a soy isoflavone, all in a dietary acceptable form in a beverage, a beverage preparation, a paste, a bar, or a cookie.

An immunogenic complex, essentially consisting of neisserial outer membrane protein proteosomes hydrophobically complexed to native purified bacterial lipopolysaccharide and formulated in accordance with the current invention for mucosal delivery such as via the oral or intranasal route is used as a vaccine. Specifically, a vaccine using shigella lipopolysaccharides complexed to proteosomes for such mucosal administration induces IgG and IgA antibodies in sera and in respiratory and intestinal fluids. Furthermore, such antibodies are associated with protection against shigella infection and these vaccines are herein demonstrated to protect against mucosal infection with shigella.

The present invention provides a solid composition for oral administration comprising: (i) a drug compound; (ii) chitosan or a derivative thereof or a salt of chitosan or salt of a derivative of chitosan; and (iii) an organic acid. Preferably the drug compound is a polar molecule having a molecular weight of 1 KDa or less, a peptide, a protein or a polysaccharide. The compositions of the invention provide enhance absorption of the drug compound.

The present invention provides a biodegradable “precision polymer system” (poly system) and methods for preparing pharmaceutically effective “precision polymer nanosystems” (polymer nanosystem) for delivery and / or targeting of drugs or drug like compounds.

The present invention relates to a method of promoting immunoglobulin A secretion in the mucosal membranes of non-human animals. The method comprises administering a foodstuff comprising glutamine to the non-human animal.

The invention relates to relates to a method for preparing a composition containing 1,3-di-unsaturated fatty acyl-2-saturated fatty acyl glyceryl ester, particularly containing 1,3-di-oleoyl-2-palmitoyl glyceryl ester (OPO), which comprises the steps of: carrying out random ester exchange on an ester rich in saturated fatty acid residue and an ester rich in unsaturated fatty acid residue serving as reaction substrates, and carrying out enzymatic oriented ester exchange on the reaction mixture and unsaturated fatty acid or unsaturated fatty acid ester. The invention also provides application of the composition to preparing formula milk powder for infant and preparing synthetic food for infant, and the formula milk powder for infant and the synthetic food for infant containing the composition.

The invention relates to preparation of a novel lysozyme oral preparation, wherein the preparation is prepared by the following steps: synthesizing lysozyme dimer proteins; preparing lysozyme dimer sodium alginate microspheres by utilizing the lysozyme dimer proteins; mixing with rice sprouts or a decoction or an adsorbent thereof. The preparation remarkably promotes the intestinal absorption efficiency of lysozyme proteins. As a novel feed additive, the preparation can replace antibiotics to enhance the production performance and nonspecific immune function of mammalian bred animals such as hogs.

The invention discloses a micro-ecology preparation for pig feed, and a preparation method thereof, and belongs to the technical field of the micro-ecology preparation. The micro-ecology preparation comprises the following raw materials in parts by weight: 0.5-1 part of enterococcus faecalis, 0.2-1.2 parts of lactobacillus johnsonii, 0.5-1.0 part of bacillus subtilis, 0.2-0.5 part of bacillus licheniformis, 1-1.5 parts of clostridium butyricum, 0.5-1.5 parts of lactobacillus acidophilus and 1.5-2.0 parts of clostridium butyricum. The micro-ecology preparation disclosed by the invention can obviously lower the incidence rate of live pig intestinal diseases, improves a piglet growth rate, reduces feed consumption and drug expenditure, and greatly lowers culture cost.

The invention belongs to the technical field of feed additives, particularly relates to a method for preparing a feed additive containing antibacterial peptides, and provides the following scheme aiming at the problems proposed in the background technology: the method comprises the following steps: S1, taking materials; s2, crushing and stirring; s3, aerobic fermentation; s4, rejuvenating the strains; s5, strain fermentation; s6, pretreatment of fermentation liquor; s7, antibacterial peptide extraction; and S8, compounding the antibacterial peptide with a feed additive. Probiotic microorganisms are added in the strain fermentation process in the step S5, and a stabilizer is added in the fermentation liquor pretreatment in the step S6 to stabilize the fermentation liquor, so that the fermentation liquor is prevented from being decomposed, the activity is improved, and the content is increased; and finally, the prepared feed additive is combined, so that the prepared feed additive containing the antibacterial peptide is high in nutrient content, beneficial to improving the growth rate of animals, beneficial to promoting intestinal absorption of the animals and beneficial to enhancing physique and immunity.

The invention discloses an application of berbamine in preparation of a medicine for treating Alzheimer's disease. The invention specifically relates to an application of berbamine hydrochloride in treatment of Alzheimer's disease. It is indicated that the berbamine hydrochloride significantly improves the pathological characteristics of mice with the Alzheimer's disease, improves the learning and memory ability of the mice with the Alzheimer's disease, and has a certain treatment effect on the Alzheimer's disease.

Described are fusion proteins of GLP-2 with an Fc region of immunoglobulin. The GLP-2 and Fc regions are separated by a linker comprised of amino acids. The fusion proteins persist and remain active in the body for longer periods of time than GLP-2 itself. Methods are disclosed of using the fusion proteins to treat and prevent enterocutaneous fistulae, radiation damage to the gastrointestinal tract, obstructive jaundice, and short bowel syndrome.

The invention discloses a preparation method of a biological feed from insect protein, which comprises the following steps: S1, selecting the following first raw materials according to a weight ratio: a strain stock solution containing a biological enzyme, first brown sugar, immune polysaccharide, Chinese herbs, composite vitamins and edible salt; S2, adding all the raw materials into water with the weight being 5-15 times that of the raw materials to form a mixed solution, and propagating the mixed solution in the environment with the temperature of 28-30 DEG C and the air humidity of 65-75% for 3-7 days; S3, selecting the following second raw materials according to the weight ratio: tenebrio molitor, hermetia illucens and barley pest, respectively collecting and separating the second raw materials, then sterilizing at high temperature, respectively grinding into pulp, and finally mixing into insect pulp; and S4, wrapping the insect pulp with a gauze bag, putting the wrapped insect pulp into the mixed solution in the step S2, adding second brown sugar, and performing fermentation in an environment with the temperature of 28-30 DEG C and the air humidity of 65-75% for 3-5 days. The preparation method of a biological feed from insect protein is applied to the technical field of biological feed.

The invention relates to a nutritional composition for infants, and in particular, relates to a nutritional composition for improving intestinal health of the infants and / or improving intestinal tolerance of the infants and / or reducing eczema of the infants, and an infant formula food. The infant nutritional composition comprises galactooligosaccharide, 1,3-dioleic acid-2-palmitic acid triglyceride, whey protein hydrolysate and other nutritional ingredients.

The present invention relates to the technical field of health-care products and particularly relates to herba dendrobii yogurt. During the preparation, the dry herba dendrobii is beat into superfine powder, the powder is mixed evenly with honey to obtain an initial material, the initial material is frozen and thawed for three times to obtain a freezing-thawing material, the freezing-thawing material and fresh milk are mixed, the mixture is poured into an empty bottle, yogurt is poured into the bottle, the yogurt is stirred rapidly until the yogurt is fully merged, the stirred yogurt is fermented, the fermented yogurt is clotted, the clotted yogurt is transferred into a refrigerator to be frozen, the frozen yogurt is inspected to be qualified, and the qualified yogurt is filled to be the herba dendrobii yogurt. The treatment method can maximally retain the active components in the herba dendrobii and the obtained herba dendrobii yogurt is stable in quality, sweet and sour, and tasty.

An object of the present invention is to provide a pharmaceutical composition that improves intestinal absorption of a compound having a structure represented by the general formula [1]. The composition containing a compound represented by the general formula [1] or a salt thereof and (b) a lipophilic substance improves intestinal absorption of the compound. In the formula, A represents —(NR4)—, —(CR5R6)— or the like; B represents an alkylene group or an alkenylene group; R1 represents an alkyl group, an alkenyl group or the like; R2 represents an adamantylalkyl group or the like; R3 represents an unsaturated heterocyclic ring; R4, R5 and R6 each represent a hydrogen atom or the like; and X represents an oxygen atom or the like.

Provided is nano-sized kimchi lactic acid bacteria, and more particularly, to Lactobacillus plantarum (L. plantarum) isolated from kimchi. The nano-sized kimchi lactic acid bacteria has an effect of inhibiting intestinal putrefactive bacteria and improving an intestinal environment through activation of an immune function, and an excellent effect of preventing and treating colorectal diseases including colitis and colorectal cancer. The nano-sized kimchi lactic acid bacteria consist of uniform particles to facilitate intestinal absorption, and an effect of improving an intestinal environment is proportionally increased according to a concentration. In addition, the nano-sized kimchi lactic acid bacteria is a food additive, which provides effects of the lactic acid bacteria without damage to natural taste and flavor of a food, and although the nano-sized kimchi lactic acid bacteria are added to a food to be heated, due to high thermal resistance, the effects are maintained.

An object of the present invention is to provide a pharmaceutical composition that improves intestinal absorption of a compound having a structure represented by the general formula [1]. The composition containing a compound represented by the general formula [1] or a salt thereof and (b) a lipophilic substance improves intestinal absorption of the compound. In the formula, A represents —(NR4)—, —(CR5R6)— or the like; B represents an alkylene group or an alkenylene group; R1 represents an alkyl group, an alkenyl group or the like; R2 represents an adamantylalkyl group or the like; R3 represents an unsaturated heterocyclic ring; R4, R5 and R6 each represent a hydrogen atom or the like; and X represents an oxygen atom or the like.

The invention relates to a new application of traditional Chinese medicine fennel. Fennel can promote intestinal absorption of lysozyme protein in the orally-taken sodium alginate microspheres so as to increase the lysozyme blood concentration and remarkably improve the bioavailability of lysozyme.

The present invention provides a biodegradable “precision polymer system” (poly system) and methods for preparing pharmaceutically effective “precision polymer nanosystems” (polymer nanosystem) for delivery and / or targeting of drugs or drug like compounds.

The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition for increasing the intestinal absorption area of ​​patients with short bowel syndrome. The pharmaceutical composition is prepared from pharmaceutically acceptable excipients and Astragalus, Atractylodes Rhizome, Angelica, Tangerine Peel, Ginger, Tsaoguo, and Prunus chinensis. The active ingredients of peach grass are preferably volatile oil components. Its formulation is preferably an oral liquid formulation. The composition can significantly increase the intestinal absorption area and gland quantity of the short bowel syndrome rat model, and improve the intestinal absorption function of the model rat.

The invention discloses a brain polypeptide preparation process: (1) degreasing pretreatment of sheep brain; (2) strain activation; (3) anaerobic fermentation of Lactobacillus plantarum No. 3; (4) Bacillus subtilis sp. .nk1 aerobic fermentation; (5) high temperature inactivation.

The invention provides a piggy feeding feed rich in Chinese herbal medicines. The piggy feeding feed comprises a basic material, a regulating material and Chinese herbal medicine liquid, wherein the basic material comprises 30-40 parts of rice, 25-30 parts of corn, 20-25 parts of wheat bran, 10-15 parts of fish meal, 10-13 parts of shrimp shells, 15-18 parts of potatoes, 10-13 parts of sweet potato leaves, 9-12 parts of argy wormwood leaves, 8-13 parts of bone meal, 10-14 parts of broom corn millet, 11-15 parts of buckwheat, 7-9 parts of cowpeas, 6-10 parts of broad beans, 3-6 parts of water spinach, 4-7 parts of camellia, 2-5 parts of water lettuce and 6-8 parts of trifolium repens. The piggy feeding feed disclosed by the invention has the beneficial effects that the piggy feeding feed isprepared from purely natural crops and Chinese herbal medicines and is free form pigment additives or hormone medicines, so that fed piggies are high in quality, durable in meat quality and little infat precipitate, the absorption and digestion capacity of intestinal tracts of pigs can be strengthened, the disease resistance of the piggies can be strengthened, and the medication risk of the piggies can be reduced.

The invention relates to a feed formula and a production technology of the feed formula, in particular to a formula of piglet feed and a production technology. The formula comprises 45-55kg corn, 45-55kg wheat, 4-6kg rice bran, 8-12kg bean cake, 0.8-1.3kg fish meal, 0.8-1.2kg bone meal, 0.3-0.5kg table salt, 0.4-0.6kg stone powder, 0.1-0.3kg copper sulfate, 0.1-0.2kg potassium sulfate, 0.01-0.03kg potassium iodate, 5000 international units of vitamin A, 500 international units of vitamin D, 20 international units of vitamin E, 10mg vitamin K, 15mg vitamin B and 10mg vitamin B2. According to the formula of the piglet feed and the production technology, the body immunity of a piglet can be improved; disease prevention and health care effects are better; an appetite of the piglet can be improved; intestinal tract absorption of the piglet is facilitated; the growth of the piglet is significantly promoted; the slaughtering weight is increased; the meat quality of a livestock product meets a pollution-free requirement; an export standard of the livestock product is met; and physical health of people is effectively ensured.