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A traditional Chinese medicine enema for treating non-alcoholic steatohepatitis and its preparation method and application method

A steatohepatitis, non-alcoholic technology, used in pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc. The effect of relieving clinical symptoms and signs, improving liver function and preventing liver fibrosis

Active Publication Date: 2021-10-26
黑龙江省医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although in the prior art, Chinese patents (patent publication numbers CN 105833179A and CN 110339252A) all disclose traditional Chinese medicines for the treatment of nonalcoholic steatohepatitis, most of the existing Chinese medicine compounds for the treatment of nonalcoholic steatohepatitis are oral preparations. Although there is a certain curative effect, due to the gastrointestinal congestion, endotoxin stimulation, intestinal flora imbalance and gastrointestinal dysfunction in patients with liver disease, they usually show more digestive tract symptoms. Intestinal irritation is great, and some patients will aggravate gastrointestinal symptoms after taking the medicine, making it difficult to adhere to treatment
Moreover, the oral preparations are destroyed by gastric acid and digestive juice, the blood drug concentration decreases, and the amount of drug entering the liver through systemic circulation is limited, resulting in low drug utilization.

Method used

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  • A traditional Chinese medicine enema for treating non-alcoholic steatohepatitis and its preparation method and application method
  • A traditional Chinese medicine enema for treating non-alcoholic steatohepatitis and its preparation method and application method

Examples

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Effect test

specific Embodiment approach 1

[0027] The traditional Chinese medicine enema composition used in the prevention and treatment of non-alcoholic steatohepatitis in this example is made of the following Chinese medicine raw materials with the following mass ratio: capillary wormwood 20g, red peony root 15g, salvia miltiorrhiza 15g, safflower 10g, peach kernel 10g, chai Hu 20g, Paeoniae Alba 20g, Rhubarb 10g, Scutellaria baicalensis 15g, Astragalus 30g, Poria cocos 15g, Stir-fried Atractylodes macrocephala 15g, Corydalis 10g, Toosendan 10g.

[0028] The specific preparation method is as follows:

[0029] (1) Weigh the crude drug according to the above ratio, put it into a casserole, add clear water to cover the medicine surface, and soak for 20 minutes;

[0030] (2) Boil the crude drug soaked in clear water in a casserole for 10 minutes with strong fire, then decoct with slow fire for 25 minutes, filter to get the decoction, and set aside;

[0031] (3) Add the remaining filter residue filtered in step 2 into c...

specific Embodiment approach 2

[0033] The traditional Chinese medicine enema composition used in the prevention and treatment of non-alcoholic steatohepatitis in this example is made of the following Chinese medicine raw materials with the following mass ratio: capillary root 30g, red peony root 20g, salvia miltiorrhiza 20g, safflower 10g, peach kernel 10g, chai Hu 30g, Baishao 25g, Rhubarb 10g, Scutellaria baicalensis 20g, Astragalus 40g, Poria cocos 20g, fried Atractylodes macrocephala 20g, Corydalis 10g, Toosendan 10g.

[0034] The specific preparation method is as follows:

[0035] (1) Weigh the crude drug according to the above ratio, put it into a casserole, add water to cover the surface of the medicine, and soak for 25 minutes;

[0036] (2) Boil the crude drug soaked in clear water in a casserole for 10 minutes with strong fire, then decoct with slow fire for 30 minutes, filter to get the decoction, and set aside;

[0037] (3) Add the remaining filter residue filtered in step 2 into clear water wit...

specific Embodiment approach 3

[0039] The traditional Chinese medicine enema composition used in the prevention and treatment of non-alcoholic steatohepatitis in this example is made of the following Chinese medicine raw materials with the following mass ratio: capillary root 25g, red peony root 15g, salvia miltiorrhiza 20g, safflower 5g, peach kernel 5g, chai Hu 30g, white peony 20g, rhubarb 5g, baicalin 15g, astragalus 25g, poria cocos 15g, fried Atractylodes macrocephala 15g, corydalis 10g, toosendan 10g.

[0040] The specific preparation method is as follows:

[0041] (1) Weigh the crude drug according to the above ratio, put it into a casserole, add clear water to cover the medicine surface, and soak for 20 minutes;

[0042] (2) Boil the crude drug soaked in clear water in a casserole for 10 minutes with strong fire, then decoct with slow fire for 20 minutes, filter to get the decoction, and set aside;

[0043] (3) Add the remaining filter residue filtered in step 2 into clear water and cover the nood...

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Abstract

The invention discloses a traditional Chinese medicine enema for treating non-alcoholic steatohepatitis and its preparation method and application method. . Based on the theory of "gut-liver axis", the present invention adopts the method of retention enema to make the drug directly absorbed through the intestinal mucosa, reduce the damage to the drug by gastric acid and digestive juice, and increase the utilization rate of the drug; it can also directly remove the intestinal cavity and intestinal mucosa Toxic metabolites and toxins in the body, adjust the intestinal flora, and prevent toxic substances from entering the liver through the enterohepatic circulation, which can effectively relieve the clinical symptoms and signs of patients, reduce liver function and blood lipid indicators, improve intestinal flora, and effectively prevent and treat non-alcoholic Steatohepatitis. In addition, the traditional Chinese medicine enema of the present invention can be used alone or in combination with other medicines and treatment methods.

Description

technical field [0001] The invention relates to a traditional Chinese medicine enema for treating non-alcoholic steatohepatitis and its preparation method and application method, in particular to a traditional Chinese medicine enema for preventing and treating non-alcoholic steatohepatitis and non-alcoholic liver fibrosis combination agent. Background technique [0002] Nonalcoholic fatty liver disease (NAFLD) is a metabolic stress-induced liver injury closely associated with insulin resistance and genetic susceptibility, including nonalcoholic hepatic steatosis, nonalcoholic steatohepatitis (NASH), cirrhosis and Hepatocellular carcinoma (HCC). With the improvement of living standards and changes in dietary structure, NAFLD has gradually become the chronic liver disease with the highest incidence in my country. NASH is an intermediate stage of simple fatty liver progressing to liver cirrhosis and HCC, and it is difficult to recover on its own. In NASH patients, the liver f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/736A61K9/00A61P1/16
CPCA61K9/0031A61K36/076A61K36/233A61K36/282A61K36/284A61K36/286A61K36/481A61K36/537A61K36/539A61K36/58A61K36/65A61K36/66A61K36/708A61K36/71A61K36/736A61K2236/331A61K2236/51A61P1/16A61K2300/00
Inventor 张晓星杨川刘延东
Owner 黑龙江省医院
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