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Gastrodin injection and preparation process thereof

A technology for gastrodin injection and gastrodin, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, cardiovascular system diseases, etc., and can solve adverse reactions, increase risks, and instability of gastrodin aqueous solution. and other problems, to achieve the effect of stable gastrodin content and high clarity

Active Publication Date: 2014-01-22
JIANGXI GUOYAO PHARMA LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the unstable gastrodin aqueous solution, after the gastrodin injection produced is sterilized, a large number of white spots and white lumps will be precipitated during storage, and will continue to increase during the storage process. Gastrodin is clinically used as When the injection is used, the existing routes of administration are intramuscular injection or intravenous infusion, and the visible foreign matter is the focus of the small-volume injection inspection. If the foreign matter is small and small, it will bring pain to the patient when injected into the patient’s body. Some may even form granulation and various adverse reactions, increasing the risk of clinical use

Method used

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  • Gastrodin injection and preparation process thereof

Examples

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Embodiment 1

[0014] Embodiment 1: a kind of gastrodin injection, comprises the raw material of following weight ratio: gastrodin 100g, lactose 0.8g, procaine hydrochloride 1.6g, sodium thiosulfate 0.5g, nicotinamide 2.6g, glycine 0.7g, water for injection 2000ml;

[0015] The preparation process of the present invention is as follows:

[0016] 1) Weigh the amount of gastrodin, add 80% of the total amount of water for injection, dissolve the drug in an ultrasonic dissolver, stir evenly, take sodium hydroxide, adjust the pH value of the liquid to 6.0, and then add lactose to obtain solution A;

[0017] 2) Take 15% of the total amount of water for injection, add procaine hydrochloride, sodium thiosulfate, nicotinamide and glycine in sequence, stir well to obtain solution B;

[0018] 3) Mix solution A and solution B, stir evenly, and then add water for injection to a sufficient amount; take a sample for inspection, measure pH and content, after passing the test, the drug solution is reduced b...

Embodiment 2

[0019] Embodiment 2: A kind of gastrodin injection comprises the following raw and auxiliary materials of weight ratio: gastrodin 100g, lactose 0.2g, procaine hydrochloride 0.9g, sodium thiosulfate 0.1g, nicotinamide 2.2g, glycine 0.4 g. Water for injection 2000ml;

[0020] The preparation process of the present invention is as follows:

[0021] 1) Weigh the amount of gastrodin, add 80% of the total amount of water for injection, dissolve the drug in an ultrasonic dissolver, stir evenly, take sodium hydroxide, adjust the pH value of the liquid to 5.0, and then add lactose to obtain solution A;

[0022] 2) Take 15% of the total amount of water for injection, add procaine hydrochloride, sodium thiosulfate, nicotinamide and glycine in sequence, stir well to obtain solution B;

[0023] 3) Mix solution A and solution B, stir evenly, and then add water for injection to a sufficient amount; take a sample for inspection, measure pH and content, after passing the test, the drug soluti...

Embodiment 3

[0024] Embodiment 3: A kind of gastrodin injection, including the following raw materials and auxiliary materials in weight ratio: gastrodin 100g, lactose 1.3g, procaine hydrochloride 2.1g, sodium thiosulfate 0.8g, nicotinamide 3.1g, glycine 1.1g, water for injection 2000ml;

[0025] The preparation process of the present invention is as follows:

[0026] 1) Weigh the amount of gastrodin, add 80% of the total amount of water for injection, dissolve the drug in an ultrasonic dissolver, stir evenly, take sodium hydroxide, adjust the pH value of the liquid to 7.0, and then add lactose to obtain solution A;

[0027] 2) Take 15% of the total amount of water for injection, add procaine hydrochloride, sodium thiosulfate, nicotinamide and glycine in sequence, stir well to obtain solution B;

[0028] 3) Mix solution A and solution B, stir evenly, and then add water for injection to a sufficient amount; take a sample for inspection, measure pH and content, after passing the test, the d...

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Abstract

The invention provides a gastrodin injection and a preparation process thereof, and the gastrodin injection can be used for reducing white spots and white blocks occurring during storage, improving the clarity, guaranteeing the safety of medication and meanwhile guaranteeing better stability. According to the gastrodin injection and the preparation process thereof, lactose, procaine hydrochloride, sodium hyposulfite, niacinamide and glycine are used as auxiliary materials; the white spots and the white blocks occurring during storage can be reduced, the clarity can be improved and the safety of medication can be guaranteed after proportioning; but meanwhile, we found that the gastrodine content is obviously reduced after the gastrodin injection is stored for a period of time after the auxiliary materials are added; after the addition sequence of the auxiliary material is adjusted by using the special technology, the content of the gastrodine in the gastrodin injection is still stable after long-time storage, so that the validity of the clinical medication is guaranteed.

Description

technical field [0001] The invention relates to an injection and a preparation process thereof, in particular to a gastrodin injection and a preparation process thereof. Background technique [0002] Gastrodin is extracted from the dried root of the orchid plant Gastrodia elata. Modern pharmacological studies have shown that gastrodin has sedative, analgesic, and hypnotic effects, as well as anticonvulsant, anti-anxiety, can increase cerebral blood flow, reduce cerebrovascular resistance, improve vertebral-basilar artery insufficiency, and has neuroprotective effects. Studies have shown that Gastrodia elata Gastrodin also has a nootropic and anti-aging effect. Foreign studies have shown that gastrodin is an effective anti-anxiety drug. [0003] Because the gastrodin aqueous solution is unstable, the produced gastrodin injection will often precipitate a large number of white spots and lumps during storage after being sterilized, and it will continue to increase during the st...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/7034A61K47/26A61P25/20A61P29/00A61P25/22A61P25/00A61P9/10A61P39/00
Inventor 钟承赞左飞鸿李进进饶建平欧阳琳曹艳林张鑫涂传平李平张宏艳陈冲邓愍民
Owner JIANGXI GUOYAO PHARMA LLC
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