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Gastrodin injection and preparation process thereof

A technology of gastrodin injection and gastrodin, which can be applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, cardiovascular system diseases, etc., and can solve problems such as adverse reactions, increased risks, and granulation formation. To achieve the effect of stable gastrodin content and high clarity

Active Publication Date: 2015-07-01
JIANGXI GUOYAO PHARMA LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the unstable gastrodin aqueous solution, after the gastrodin injection produced is sterilized, a large number of white spots and white lumps will be precipitated during storage, and will continue to increase during the storage process. Gastrodin is clinically used as When the injection is used, the existing routes of administration are intramuscular injection or intravenous infusion, and the visible foreign matter is the focus of the small-volume injection inspection. If the foreign matter is small and small, it will bring pain to the patient when injected into the patient’s body. Some may even form granulation and various adverse reactions, increasing the risk of clinical use

Method used

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  • Gastrodin injection and preparation process thereof
  • Gastrodin injection and preparation process thereof

Examples

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Effect test

Embodiment 1

[0014] Example 1: A gastrodin injection comprising the following raw materials in weight ratio: gastrodin 100g, lactose 0.8g, procaine hydrochloride 1.6g, sodium thiosulfate 0.5g, nicotinamide 2.6g, glycine 0.7g, 2000ml water for injection;

[0015] The preparation process of the present invention is as follows:

[0016] 1) Weigh the dosage of gastrodin, add 80% of the total amount of water for injection, dissolve the drug in an ultrasonic dissolver, stir evenly, take sodium hydroxide, adjust the PH value of the drug solution to 6.0, and then add lactose to obtain solution A;

[0017] 2) Take 15% of the total amount of water for injection, add procaine hydrochloride, sodium thiosulfate, nicotinamide and glycine in sequence, stir evenly to obtain solution B;

[0018] 3) Mix solution A and solution B, stir well, and then add water for injection to a sufficient amount; take samples and send for inspection, determine pH and content, after passing the drug solution through 0.22μm micropore...

Embodiment 2

[0019] Example 2: A gastrodin injection including the following raw materials in weight ratio: gastrodin 100g, lactose 0.2g, procaine hydrochloride 0.9g, sodium thiosulfate 0.1g, nicotinamide 2.2g, and glycine 0.4 g. 2000ml water for injection;

[0020] The preparation process of the present invention is as follows:

[0021] 1) Weigh the dosage of gastrodin, add 80% of the total amount of water for injection, dissolve the drug in an ultrasonic dissolver, stir evenly, take sodium hydroxide, adjust the PH value of the drug solution to 5.0, and then add lactose to obtain solution A;

[0022] 2) Take 15% of the total amount of water for injection, add procaine hydrochloride, sodium thiosulfate, nicotinamide and glycine in sequence, stir evenly to obtain solution B;

[0023] 3) Mix solution A and solution B, stir well, and then add water for injection to a sufficient amount; take samples and send for inspection, determine pH and content, after passing the drug solution through 0.22μm micro...

Embodiment 3

[0024] Example 3: A gastrodin injection comprising the following raw materials in weight ratio: gastrodin 100g, lactose 1.3g, procaine hydrochloride 2.1g, sodium thiosulfate 0.8g, nicotinamide 3.1g, glycine 1.1g, 2000ml water for injection;

[0025] The preparation process of the present invention is as follows:

[0026] 1) Weigh the dosage of gastrodin, add 80% of the total amount of water for injection, dissolve the drug in an ultrasonic dissolver, stir evenly, take sodium hydroxide, adjust the pH of the drug solution to 7.0, and then add lactose to obtain solution A;

[0027] 2) Take 15% of the total amount of water for injection, add procaine hydrochloride, sodium thiosulfate, nicotinamide and glycine in sequence, stir evenly to obtain solution B;

[0028] 3) Mix solution A and solution B, stir well, and then add water for injection to a sufficient amount; take samples and send for inspection, determine pH and content, after passing the drug solution through 0.22μm micropores, the...

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Abstract

The invention provides a gastrodin injection and a preparation process thereof, and the gastrodin injection can be used for reducing white spots and white blocks occurring during storage, improving the clarity, guaranteeing the safety of medication and meanwhile guaranteeing better stability. According to the gastrodin injection and the preparation process thereof, lactose, procaine hydrochloride, sodium hyposulfite, niacinamide and glycine are used as auxiliary materials; the white spots and the white blocks occurring during storage can be reduced, the clarity can be improved and the safety of medication can be guaranteed after proportioning; but meanwhile, we found that the gastrodine content is obviously reduced after the gastrodin injection is stored for a period of time after the auxiliary materials are added; after the addition sequence of the auxiliary material is adjusted by using the special technology, the content of the gastrodine in the gastrodin injection is still stable after long-time storage, so that the validity of the clinical medication is guaranteed.

Description

Technical field [0001] The invention relates to an injection and a preparation process thereof, in particular to a gastrodin injection and a preparation process thereof. Background technique [0002] Gastrodin is extracted from the dried roots of the orchid plant Gastrodia. Modern pharmacological studies have shown that gastrodin has sedative, analgesic, and sleeping effects. It can also resist convulsions, anti-anxiety, increase cerebral blood flow, reduce cerebrovascular resistance, improve blood supply to the vertebral basilar artery, and has neuroprotective effects. Research shows that gastrodia Gastrodin also has nootropic and anti-aging effects. Foreign studies have shown that gastrodin is an effective anti-anxiety drug. [0003] As the aqueous solution of gastrodin is unstable, after sterilization of the gastrodin injection produced, a large number of white spots and lumps will often precipitate during storage, and will continue to increase during the placement process. Gas...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/7034A61K47/26A61P25/20A61P29/00A61P25/22A61P25/00A61P9/10A61P39/00
Inventor 钟承赞左飞鸿李进进饶建平欧阳琳曹艳林张鑫涂传平李平张宏艳陈冲邓愍民
Owner JIANGXI GUOYAO PHARMA LLC
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