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Method for producing compound procaine hydrochloride capsules

A technology of procaine hydrochloride and production method, which is applied in the field of production of compound procaine hydrochloride capsules, can solve the problems of low drug dissolution rate and poor particle fluidity, and achieve good dissolution rate, low cost and stable production process Effect

Active Publication Date: 2015-12-16
CHENGDU TONGDE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is a pungent and unpleasant smell in the traditional preparation method, and the particle fluidity is poor during the filling process, and the dissolution rate of the drug is also low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: a kind of production method of compound procaine hydrochloride capsule, described compound procaine hydrochloride capsule is made of procaine hydrochloride, vitamin B6, inositol, glutamic acid, starch, benzoic acid, diphosphate Potassium hydrogen, potassium metasulfite and talc, it includes the following steps:

[0020] S1. Weighing: Weigh each raw material according to the formula ratio, and set aside; the formula ratio is as follows: 0.1 parts by weight of potassium dihydrogen phosphate, 50 parts by weight of procaine hydrochloride, 15 parts by weight of vitamin B6, 8 parts by weight of inositol, gluten 10 parts by weight of amino acid, 30 parts by weight of starch, 2 parts by weight of benzoic acid, 1 part by weight of potassium metasulfite, 2 parts by weight of talcum powder;

[0021] S2. Pulverization: Stir and mix procaine hydrochloride, glutamic acid and starch evenly, pulverize the mixture into fine powder with a pulverizer and pass through a 60-me...

Embodiment 2

[0027] Embodiment 2: a kind of production method of compound procaine hydrochloride capsule, described compound procaine hydrochloride capsule is made of procaine hydrochloride, vitamin B6, inositol, glutamic acid, starch, benzoic acid, diphosphate Potassium hydrogen, potassium metasulfite and talc, it includes the following steps:

[0028] S1. Weighing: Weigh each raw material according to the formula ratio, and set aside; the formula ratio is as follows: 0.5 parts by weight of potassium dihydrogen phosphate, 70 parts by weight of procaine hydrochloride, 25 parts by weight of vitamin B6, 15 parts by weight of inositol, gluten 25 parts by weight of amino acid, 40 parts by weight of starch, 7 parts by weight of benzoic acid, 5 parts by weight of potassium metasulfite, 10 parts by weight of talcum powder;

[0029] S2. Pulverization: Stir and mix procaine hydrochloride, glutamic acid and starch evenly, pulverize the mixture into fine powder with a pulverizer and pass through a 10...

Embodiment 3

[0035] Embodiment 3: a kind of production method of compound procaine hydrochloride capsule, described compound procaine hydrochloride capsule is made of procaine hydrochloride, vitamin B6, inositol, glutamic acid, starch, benzoic acid, diphosphate Potassium hydrogen, potassium metasulfite and talc, it includes the following steps:

[0036] S1. Weighing: Weigh each raw material according to the formula ratio, and set aside; the formula ratio is as follows: 0.2 parts by weight of potassium dihydrogen phosphate, 55 parts by weight of procaine hydrochloride, 22 parts by weight of vitamin B6, 13 parts by weight of inositol, gluten 15 parts by weight of amino acid, 37 parts by weight of starch, 6 parts by weight of benzoic acid, 2 parts by weight of potassium metasulfite, 8 parts by weight of talcum powder;

[0037] S2. Pulverization: Stir and mix procaine hydrochloride, glutamic acid and starch evenly, pulverize the mixture into fine powder with a pulverizer and pass through an 80...

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PUM

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Abstract

The invention discloses a method for producing compound procaine hydrochloride capsules. According to the method, procaine hydrochloride, glutamic acid and starch are premixed and then smashed and screened, and potassium metbisulphite, talcum powder and benzoic acid are premixed and then smashed and screened; monopotassium phosphate is dissolved in purified water to serve as a bonding agent, then a soft material is made with an efficient wet granulation machine by means of procaine hydrochloride, vitamin B6, inositol, glutamic acid and starch, granulation is conducted with a swing type granulation machine, drying is conducted, and the potassium metbisulphite, the benzoic acid and the talcum powder are added during total blending. By the adoption of the method, the problem of traditional methods that a large amount of irritating odor is generated during production is solved, prepared granules are high in mobility and dissolution rate, filling is smooth, and the manufacturing technique is more stable. Operation is easy, preparation is convenient, cost is low, and the method is suitable for industrial large-scale production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a production method of compound procaine hydrochloride capsules. Background technique [0002] Procaine hydrochloride, a local anesthetic, is one of the clinical drugs widely used at home and abroad, and has been included in the pharmacopoeias of China, the United States, Britain, Japan, Germany, France, Italy, and Switzerland. [0003] Procaine hydrochloride is an ester local anesthetic, which can temporarily block the conduction of nerve fibers and has an anesthetic effect. This product has weak penetrating power to the skin and mucous membranes, so it is not suitable for topical anesthesia. This product has poor diffusion and permeability, and its hydrochloride combined form releases free base in the tissue to exert local anesthetic effect. This product has constant inhibition and excessive excitement on the central nervous system. It first causes sedation, dizzine...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/245A61K47/02A61K47/36A61P15/12A61P9/10A61P25/00A61P25/20A61P25/22A61K31/047A61K31/198A61K31/4415
Inventor 梁星范伟川
Owner CHENGDU TONGDE PHARMA
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