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32results about How to "Reduce the injection dose" patented technology
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Preparation method for iron sucrose bulk drug and injection thereof
InactiveCN101671373AImprove stabilityGood water solubilityOrganic active ingredientsSugar derivativesAcetic acidIron salts
The invention relates to a preparation method for an iron sucrose bulk drug. The method comprises the following steps: (1) crystallization: the pH value of sucrose solution is adjusted to 1-4 with acetic acid, iron salt solution is added to the sucrose solution to form mixed liquor, the pH value of the mixed liquor is adjusted to 1-3 with Na2CO3 solution, then the mixed liquor is stirred and is continued to be added with the Na2CO3 solution until turbidity appears in the mixed liquor, the pH value of the mixed liquor is adjusted to 4-7, and then the mixed liquor is filtered and added with water to obtain iron cake solution; (2) complexing: the sucrose solution is heated and added with alkaline liquor for alkalization, and then the alkalized sucrose solution is added with the iron cake solution and stands for the night to obtain complexing solution; and (3) refining: the complexing solution after standing for the night is filtered, and the filtrate precipitates with 2-3 times of 95 percent of ethanol and is filtered to obtain the iron sucrose bulk drug. The invention has the advantages of simple process steps, easy control of the reaction processes, good product quality, high yieldand lower production cost and is a high-novelty preparation method for the iron sucrose bulk drug and the injection thereof.
Owner:TIANJIN ZHONGAO BIOTECH
Polysaccharide macromolecular paramagnetic metal complex and synthesis method and application thereof
InactiveCN101619106AIncreased toxicityShort retention timeIn-vivo testing preparationsLymphatic vesselSynthesis methods
The invention relates to a polysaccharide macromolecular paramagnetic metal complex and a synthesis method and an application thereof. Polysaccharide macromolecules are used as carriers, and a ligand compound, the side chains of which contain open-chain or annular polyamino polycarboxylic compounds, acts with paramagnetic metal ions to form the paramagnetic metal complex, wherein the paramagnetic metal ions are positive divalent or trivalent ions of metal elements, the atomic numbers of which are 21-29, 42 and 44 or 57-71. The polysaccharide macromolecular paramagnetic metal complex can be used as a magnetic resonance imaging contrast agent for lymphatic organs, lymphatic vessels, lymphatic systems and cardiovascular systems of people or other mammals.
Owner:WUHAN INSTITUTE OF TECHNOLOGY
Enrofloxacin suspension and its prepn process
InactiveCN1706386ASlow absorptionGood curative effectAntibacterial agentsOrganic active ingredientsBlood drug concentrationPropanediol
The present invention is enroloxacin suspension and its preparation process and belongs to veterinary medicine technology. The enroloxacin suspension includes enroloxacin 8-12 wt%, butyl oleate 3-8 wt%, polysorbate 3-8 wt% and propylene glycol 30-50 wt% except water. The enroloxacin suspension is prepared through D phase emulsifying process, and is white and ropy. The enroloxacin suspension has slow release of the effective medicine component, high bioavailability, enhanced medicinal effect, long effective blood medicine concentration maintaining period up to 48 hr, low cost and other advantages.
Owner:史同瑞
Long-acting recombinant human chorionic gonadotrophin-Fc fusion protein
ActiveCN103897064AImprove biological activityProlong half-life in vivoPeptide/protein ingredientsPeptide preparation methodsProtein compositionHalf-life
The invention discloses a recombinant human chorionic gonadotrophin-Fc fusion protein (HCG-Fc for short) and a preparation method thereof. The HCG-Fc protein is a dimerized fusion protein, and the amino acid sequence of the fusion protein sequentially comprises an HCG beta subunit, an HCG alpha subunit, a flexible peptide joint and a human IgG Fc mutant from an N end to a C end. Compared with the existing chorionic gonadotrophin, the fusion protein has longer in-vivo half life, higher bioavailability and lower side effect. The invention also relates to an application of a recombinant HCG-Fc fusion protein composition in preparation of medicaments for treating and / or preventing infertility.
Owner:UNICOHEALTH CO LTD
siRNA-IR sequence for sex reversal of male macrobrachium rosenbergii and application of siRNA-IR sequence
ActiveCN110714009AReduce immune stress responseImprove survival rateAnimal husbandryDNA/RNA fragmentationPhysiologySexual differentiation
The invention discloses a siRNA-IR sequence for sex reversal of male macrobrachium rosenbergii and application of the siRNA-IR sequence. Expression of an IR gene is inhibited by a siRNA interference technology to promote sex reversal of the male macrobrachium rosenbergii to obtain neo-females. IR gene fragments of macrobrachium rosenbergii are screened and obtained from macrobrachium rosenbergii transcriptome, and the siRNA is designed and synthesized according to a macrobrachium rosenbergii IR gene sequence, named siRNA-IR. The siRNA-IR is transformed into macrobrachium rosenbergii by a microscopic injection method before a sex differentiation stage to interfere and inhibit expression of the IR gene in the macrobrachium rosenbergii and promote sex interversal of the macrobrachium rosenbergii. Compared with a dsRNA interference technology, the siRNA technology has smaller injection dosage, and can reduce the cost, effectively reduce immunological stress reactions of post-larvae of themacrobrachium rosenbergii and increase the survival rate of neo-females.
Owner:HUAZHONG AGRI UNIV
Image processing method and device and computer readable storage medium
ActiveCN111340904AImproved loss functionSave resourcesImage enhancementReconstruction from projectionImaging processingImaging quality
The embodiment of the invention provides an image processing method and device and a computer readable storage medium. The method comprises the steps that an image processing request of a client is received, the image processing request comprises projection data to be processed, and the image processing request is used for requesting to reconstruct an image according to the projection data to be processed; domain transformation processing is carried out on the to-be-processed projection data to obtain image data; an image processing model is called to perform image reconstruction processing onthe image data to obtain an image result, the image processing model being obtained by training the image processing model according to the image sample data and the target sample data; and image results are sent to a client. By adopting the embodiment of the invention, the imaging quality of positron emission tomography is improved while the injection dosage of the tracer agent is reduced and the radiation is reduced, and the diagnosis and screening of diseases are facilitated.
Owner:SHENZHEN INST OF ADVANCED TECH
Method of inducing antitumor immunity and its application in preparing medicine
InactiveCN1887296AGrowth inhibitionGrowth Prevention and InhibitionPowder deliveryMammal material medical ingredientsAntitumor immunityFreeze-drying
The present invention discloses method of inducing antitumor immunity and its application in preparing medicine. The method is to induce antitumor immunity with live myeloma FO cell, freeze dried powder of GM-CSF transfected myeloma FO cell, primary human umbilical vein vessel endothelial cell, or the extract of tumor vessel endothelial cell membrane surface protein. The method may be used in preparing antitumor medicine and has simple operation and high antitumor immunity inducing effect.
Owner:南京大学生物制药工程研究中心
Perfluocarbon silicon plastid as well as preparation method and application thereof
ActiveCN112546062AImprove stabilityGuaranteed stabilityOrganic active ingredientsInorganic active ingredientsHigh-intensity focused ultrasoundDrug release
The invention discloses a silicon plastid-entrapped perfluocarbon preparation as well as a preparation method and application thereof. The prepared preparation can be used as an oxygen and drug delivery system to synchronously deliver oxygen and drugs to tumors in a targeted manner, and under the stimulation of high-intensity focused ultrasound, oxygen and drugs can be quickly released at tumor parts, the hypoxic microenvironment of tumors is improved, and the drug effect of the drugs is improved. A silicate network structure on the surface of the silicon plastid enables the preparation to have good structural stability and drug loading stability, early leakage of drugs in a blood circulation system can be reduced, and toxic and side effects of the drugs are reduced. The preparation can also enhance the effect of ultrasonic imaging and realize drug delivery and drug release under image monitoring.
Owner:INSITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES +1
Long-acting recombinant human chorionic gonadotropin fusion protein
ActiveCN103897064BProlong half-life in vivoImprove bioavailabilityPeptide/protein ingredientsPeptide preparation methodsProtein compositionHalf-life
Owner:UNICOHEALTH CO LTD
Hepatitis B virus vaccine synergistic protein and its gene
InactiveCN1948493AImproving immunogenicityImprove immunityBacteriaPeptide/protein ingredientsSequence analysisHepatitis B immunization
This invention relates to a hepatitis B virus vaccine synergic protein and its genes, and utilizes gene engineering principle to express the method and application of the protein. CDNA of the protein is gained by screening from human liver CDNA expression bank, after sequence analysis ,using the way of gene engineering to clone to prokaryotic cell, eukaryotic cell(animals, plants) to express protein by coding of the CDNA ,for instance ,cloning CDNA to prokaryotic expression vector and gaining recombination protein by expression depuration in Bacterium coli. Combination of the protein and hepatitis B virus vaccine can improve vaccine immune effectiveness, reinforcing the immunity of hepatitis B virus infectors, increasing antibody titer. Protein of this invention can be used as adjuvant to hepatitis B vaccine.
Owner:FUDAN UNIV
Medical inflation and curing bone-forming agent for strengthening vertebral body
The invention discloses a medical inflation and curing bone-forming agent for strengthening a vertebral body, which is prepared by mixing the following components in percentage by weight: 10 to 20 percent of expanding agent, 30 to 40 percent of curing agent, 30 to 40 percent of bone-forming agent and the balance of water, wherein the total weight percentage of the expanding agent, the curing agent, the bone-forming agent and the distilled water is 100 percent. The whole strengthening degree of the vertebral body can be obviously enhanced under an osteoporosis condition; the stability of the vertebral body is improved; the leakage of a filled material is reduced; the distribution uniformity of the filled material in the vertebral body is improved; new bones are promoted to be formed in the vertebral body at the same time; an osteoporosis state is improved; and the clinical treatment effect is effectively improved. The medical inflation and curing bone-forming agent is a vertebral body strengthening material, which is obvious in expansion effect and good in mechanical property and bone-forming effect.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY
Nuclear magnetism-optical dual-mode imaging biconical DNA nanoprobe, and preparation method and application thereof
ActiveCN110257374AHigh resolutionImaging effectGeneral/multifunctional contrast agentsDNA/RNA fragmentationDual modeA-DNA
The invention provides a nuclear magnetism-optical dual-mode imaging biconical DNA nanoprobe, and a preparation method and an application thereof. The dual-mode imaging DNA probe is prepared from a DNA nanostructure, a nucleic acid aptamer, a chemical fluorescent molecule and a nuclear magnetism resonance imaging contrast agent. The DNA probe provided by the invention improves the stability of the nuclear magnetism resonance imaging contrast agent and the chemical fluorescent molecule in body circulation, reduces the potential biological toxicity of gadolinium ions, and improves the targeting ability of tumors by using the nucleic acid adapter, and maintains the T1 relaxation efficiency equivalent to that of a clinical nuclear magnetism resonance contrast agent when the gadolinium content is only 1 / 20 of the clinical dose. With the synergistic effect of magnetic resonance imaging and fluorescence imaging, the DNA probe achieves higher resolution ratio and sensitivity of tumor imaging, and provides powerful technical means for early diagnosis of tumors.
Owner:THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
Mixed liquor for labeling and labeling method for animals
InactiveCN101497779AReduce the injection doseStrong concealmentOther chemical processesClimate change adaptationSimple componentNon magnetic
The invention relates to mixture indicator and an animal indicating method, belongs to an indicating method, and provides mixture indicator and an animal indicating method adopting the mixture indicator. Raw materials of the mixture indicator comprise magnetic particle and edible oil, wherein the magnetic particle at least contains iron and carbon. The mixture indicator is injected into an object to be indicated, a detector determines whether the object is indicated or not, and the indicated object is replaced after the indication is completed. Because the raw materials of the mixture indicator have simple component, stable chemical property, easy obtaining of the raw materials, low cost and easy preparation, the injection quantity of the mixture indicator is little, the indicating speed is very high, and the indicating cost is very low. The invention not only influences the indicated object little, but also has higher safety to a human body, has wide range of application, especially the application to living microbe, such as the cultivation of bionts of rabbit fish, amphioxus, loach, bird, and the like, and can be also used as an indicator of a nonmagnetic product (the product without influencing magnetic lines).
Owner:罗士柱
Tree shape Macro molecule paramagnetic metal complex and synthetic method and use
InactiveCN1944437AIncreased toxicityShort retention timeGroup 1/11 element organic compoundsGroup 8/9/10/18 element organic compoundsHuman bodyMammal
The present invention relates to one kind of tree-shaped macromolecular paramagnetic metal complex and its synthesis process and use. The paramagnetic metal complex consists of tree-shaped macromolecular with 1, 4, 7, 10-tetraazacyclo dodeane nucleus as carrier, polycarboxylic acid with opened or ring side chain as the ligand and paramagnetic metal +2 or +3 ion of element with atomic number of 21-29, 42, 44 or 57-71. The paramagnetic metal complex may be used in magnetic resonant imaging analysis, X-ray CT, ultrasonic imaging diagnosis of the lymphatic system and cardiovascular system of human body and other mammal.
Owner:WUHAN INSTITUTE OF TECHNOLOGY
Pancreatic cancer double-targeted polymer magnetic nanoparticles and preparation method and application thereof
ActiveCN109395102AImprove tumor targetingReduce the injection doseEmulsion deliveryMacromolecular non-active ingredientsMotilityMagnetite Nanoparticles
The invention discloses pancreatic cancer double-targeted polymer magnetic nanoparticles. The pancreatic cancer double-targeted polymer magnetic nanoparticles are prepared from the following components: CKAAKN-hyaluronan-vitamin E succinate polymer micelle, a ferroferric oxide magnetic nanoparticle solution and deionized water through a following method that a hyaluronan-vitamin E succinate copolymer modified by CKAAKN polypeptides is wrapped with ultra-small paramagnetic Fe3O4 magnetic nanoparticles. According to the pancreatic cancer double-targeted polymer magnetic nanoparticles, the polymer magnetic nanoparticles subjected to targeted modifying by the CKAAKN polypeptides can simulate a Wnt protein to be specifically bound with a pancreatic cancer cell membrane receptor through a Wnt signaling pathway, meanwhile, a hyaluronan receptor CD44 and a receptor for hyaluronan-mediated motility (RHAMM) can also be highly expressed on the surfaces of tumor cells, therefore, pancreatic cancercells can be subjected to specific targeting in early diagnosis of pancreatic cancer, and accordingly, a double-targeted magnetic resonance contrast agent with higher specificity and imaging abilityis provided for early diagnosis of the pancreatic cancer.
Owner:贵州中医药大学
Tumor targeting poly-asparagine free radical compounds and synthesizing method and use
InactiveCN101259281AShort retention timeFast metabolismPharmaceutical non-active ingredientsIn-vivo testing preparationsTumor targetSide chain
The invention relates to a tumor targeting poly-asparagine radical compound and a synthetic method and uses thereof. The poly-asparagine radical compound consists of a carrier of poly-asparagine macromolecule and a side chain which has a tumor targeting group and a stable radical compound. The compound can be used for electron paramagnetic resonance imaging analysis and magnetic resonance imaging analysis of various tumors or cancer pathological changes in human bodies or other mammal bodies, X-ray CT and ultrasonic image medicinal imaging diagnosis.
Owner:WUHAN INSTITUTE OF TECHNOLOGY
siRNA-IR sequence and application of male Macrobrachium rosenbergii sex transition
ActiveCN110714009BReduce immune stress responseImprove survival rateAnimal husbandryDNA/RNA fragmentationShrimpPhysiology
The invention discloses a siRNA-IR sequence of male Macrobrachium rosenbergii sex transition and its application; it uses siRNA interference technology to inhibit the expression of IR gene, promotes the sex transition of male Macrobrachium rosenbergii, and obtains pseudo-female shrimp; The IR gene fragment of Macrobrachium rosenbergii was screened and obtained from the transcriptome of Macrobrachium rosenbergii, and siRNA was designed and synthesized according to the IR gene sequence of Macrobrachium rosenbergii, named siRNA‑IR. Before the sex differentiation period, it was introduced into Macrobrachium rosenbergii by microinjection method, interfered and inhibited the expression of IR gene in Macrobrachium rosenbergii, and promoted the sex transition of Macrobrachium rosenbergii. Compared with dsRNA interference technology, siRNA interference technology has a smaller injection dose, can reduce costs, can effectively reduce the immune stress response of postlarvae of Macrobrachium rosenbergii, and improve the survival rate of pseudo female shrimp.
Owner:HUAZHONG AGRI UNIV
Medical inflation and curing bone-forming agent for strengthening vertebral body
The invention discloses a medical inflation and curing bone-forming agent for strengthening a vertebral body, which is prepared by mixing the following components in percentage by weight: 10 to 20 percent of expanding agent, 30 to 40 percent of curing agent, 30 to 40 percent of bone-forming agent and the balance of water, wherein the total weight percentage of the expanding agent, the curing agent, the bone-forming agent and the distilled water is 100 percent. The whole strengthening degree of the vertebral body can be obviously enhanced under an osteoporosis condition; the stability of the vertebral body is improved; the leakage of a filled material is reduced; the distribution uniformity of the filled material in the vertebral body is improved; new bones are promoted to be formed in the vertebral body at the same time; an osteoporosis state is improved; and the clinical treatment effect is effectively improved. The medical inflation and curing bone-forming agent is a vertebral body strengthening material, which is obvious in expansion effect and good in mechanical property and bone-forming effect.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY
Antibody labeled porphyrin iso-indole free radical compound and synthetic method thereof
InactiveCN103483451BImprove imaging effectIncreased sensitivityImmunoglobulins against cell receptors/antigens/surface-determinantsTumor targetDiagnostic agent
The invention particularly relates to a kind of antibody labeled porphyrin iso-indole free radical compound, which has the structural formula as shown in the formula I, and further relates to a synthetic method of the antibody labeled porphyrin iso-indole free radical compound and the application of the antibody labeled porphyrin iso-indole free radical compound used as an electron paramagnetic resonance diagnostic agent. A porphyrin iso-indole free radical compound and a tumor-targeting group GPC3-mAb monoclonal antibody are connected through a covalent bond so as to form a compound; the compound forms the electron paramagnetic resonance diagnostic agent with a medicinal vector or a forming body. The diagnostic agent can be selectively absorbed by hepatoma cells, the targeted imaging can be achieved, the contrast degree and definition of imaging can be improved, the imaging effect is good, the using amount is low, and the toxicity is less.
Owner:WUHAN INSTITUTE OF TECHNOLOGY
A kind of pancreatic cancer dual-targeting polymer magnetic nanoparticles and its preparation method and application
ActiveCN109395102BImprove tumor targetingReduce the injection doseEmulsion deliveryMacromolecular non-active ingredientsPancreas CancersCD44
A dual-targeting polymer magnetic nanoparticle for pancreatic cancer, the magnetic nanoparticle is made of the following components and methods: CKAAKN-hyaluronic acid-vitamin E succinate polymer micelles, ferroferric oxide magnetic nanoparticle solution , deionized water, hyaluronic acid-tocopherol succinate copolymer modified by CKAAKN polypeptide is encapsulated with ultra-small paramagnetic Fe 3 o 4 Made of magnetic nanoparticles, the present invention designs polymer magnetic nanoparticles modified by CKAAKN polypeptides to mimic Wnt protein to specifically bind to pancreatic cancer cell membrane receptors through the Wnt signaling pathway, and at the same time, the surface of tumor cells can also highly express hyaluronic acid Acid receptors——CD44 and hyaluronic acid-mediated automaticity receptors (RHAMM), so they can specifically target pancreatic cancer cells in the early diagnosis of pancreatic cancer, thus providing a specific and imaging method for early diagnosis of pancreatic cancer Dual-targeting MRI contrast agents with enhanced capabilities.
Owner:贵州中医药大学
Method for preparing Gd3<+> magnetic resonance imaging contrast agent with graphene oxide serving as carrier
InactiveCN103330950BGood water dispersion stabilityHigh longitudinal relaxation efficiencyNMR/MRI constrast preparationsDispersion stabilityChloroacetic acids
Owner:XI AN JIAOTONG UNIV
Enrofloxacin suspension and its prepn process
InactiveCN1277540CSlow absorptionGood curative effectAntibacterial agentsOrganic active ingredientsCurative effectBioavailability
The present invention is enroloxacin suspension and its preparation process and belongs to veterinary medicine technology. The enroloxacin suspension includes enroloxacin 8-12 wt%, butyl oleate 3-8 wt%, polysorbate 3-8 wt% and propylene glycol 30-50 wt% except water. The enroloxacin suspension is prepared through D phase emulsifying process, and is white and ropy. The enroloxacin suspension has slow release of the effective medicine component, high bioavailability, enhanced medicinal effect, long effective blood medicine concentration maintaining period up to 48 hr, low cost and other advantages.
Owner:史同瑞
NMR-optical dual mode imaging biconical DNA nanoprobe and its preparation method and application
ActiveCN110257374BHigh resolutionImaging effectGeneral/multifunctional contrast agentsDNA/RNA fragmentationAptamerA-DNA
The invention provides a nuclear magnetism-optical dual-mode imaging biconical DNA nanoprobe, and a preparation method and an application thereof. The dual-mode imaging DNA probe is prepared from a DNA nanostructure, a nucleic acid aptamer, a chemical fluorescent molecule and a nuclear magnetism resonance imaging contrast agent. The DNA probe provided by the invention improves the stability of the nuclear magnetism resonance imaging contrast agent and the chemical fluorescent molecule in body circulation, reduces the potential biological toxicity of gadolinium ions, and improves the targeting ability of tumors by using the nucleic acid adapter, and maintains the T1 relaxation efficiency equivalent to that of a clinical nuclear magnetism resonance contrast agent when the gadolinium content is only 1 / 20 of the clinical dose. With the synergistic effect of magnetic resonance imaging and fluorescence imaging, the DNA probe achieves higher resolution ratio and sensitivity of tumor imaging, and provides powerful technical means for early diagnosis of tumors.
Owner:THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
Injectable composition containing tilmicosin and sulfonamides, and preparation process
InactiveCN103655594ARelieve painLess irritatingAntibacterial agentsOrganic active ingredientsSulfur drugDisease
The invention relates to an injectable composition containing tilmicosin and sulfonamides, and a preparation process thereof. The composition comprises 4.0%-30.0% (W / V) of sulfonamides, 4.0%-20.0% (W / V) of tilmicosin, 0.05%-0.40% (W / V) of antioxidant, 0.01-15% (W / V) of cosolvent, 1.0%-10.0% (W / V) of pH value buffer salt, 0.01%-0.5% (W / V) of preservative and 0.01%-0.04% (W / V) of complexing agent. The injectable composition containing tilmicosin and sulfonamides provided by the invention has the advantages of high drug ingredient content, low usage volume, the alleviation of pain and the reduction of irritation of animals, the reduction of adverse effect and safety accidents caused by an organic solvent, low manufacture cost, simple production and the like. The injectable composition containing tilmicosin and sulfonamides can be used for preventing and treating bacterial mixed infection diseases.
Owner:RINGPU TIANJIN BIOLOGICAL PHARMA
Corpus antiseptic and its preparation method
InactiveCN101305710BImprove permeabilityPreserve immune activityDead animal preservationBenzoic acidSodium acetate
The invention discloses a corpse conserving agent and a preparation method thereof. The corpse conserving agent comprises the following raw materials with the following volume content: 150 to 400 parts of formaldehyde, 60 to 200 parts of benzoic acid-ethyl alcohol solution, 20 to 100 parts of sodium acetate solution, 10 to 120 parts of acetone, 3 to 80 parts of glacial acetic acid and 0.5 to 1.5 parts of perfume. The benzoic acid-ethyl alcohol solution is formed by benzoic acid dissolved in 95 percent ethyl alcohol, and the sodium acetate solution is formed by sodium acetate dissolved in distilled water. The preparation method comprises the following steps: (1) taking the benzoic acid to dissolve in the 95 percent ethyl alcohol so as to form the benzoic acid-ethyl alcohol solution and then shaking evenly; (2) taking the sodium acetate solution to dissolve in the distilled water so as to form the sodium acetate solution and then mixing uniformly; and (3) mixing and shaking the formaldehyde, the acetone, the benzoic acid-ethyl alcohol solution, the sodium acetate solution and the glacial acetic acid, and finally dropping the perfume. By using the corpse conserving agent of the invention, only individual positions of the corpse are required to be injected, without corpse immersion, therefore, the purposes of short-term corpse corrosion protection and preservation can be achieved,the toxic action of formaldehyde can be reduced, and the corpse conserving agent has the advantages of mold prevention, security and corrosion protection, stable performance and no pollution to the surrounding environment.
Owner:陈庆明
Method for improving life quality of diabetic patients by applying stem cell therapy
InactiveCN111035656AImprove the quality of lifeLower fasting blood sugarMetabolism disorderAntinoxious agentsRegimenStromal cell
The invention discloses a method for improving life quality of diabetic patients by applying stem cell therapy. The method comprises the following steps: extracting adipose tissue-derived stromal cells of diabetic patients, and carrying out cold chain transportation of the adipose tissue-derived stromal cells to a GMP laboratory to carry out treatment culture and amplification; three weeks later,when the mesenchymal stem cells are cultured to be mature, transporting back to a hospital through cold chain transportation; carrying out back transfusion of the mesenchymal stem cells to diabetic patients in the hospital, wherein the quantity of the mesenchymal stem cells injected into a diabetic patient each time is 20,000-30,000 units / kg, the mesenchymal stem cells are injected once every halfa month, one treatment course comprises 7-12 times of continuous injection, and the mesenchymal stem cells are continuously used for 3-4 treatment courses according to the illness degree of the diabetic patients. The method provided by the invention can safely and effectively improve diabetes mellitus, significantly improve the life quality of diabetic patients, make it possible to reverse diabetes mellitus, also can well control blood glucose, and can significantly reduce fasting blood glucose and HbA1c of diabetic patients.
Owner:卡替(上海)生物技术有限公司
ND4 gene recombinant adenovirus associated virus vector and preparation method and application thereof
InactiveCN112111515ARandom combinationHigh expressionPolypeptide with localisation/targeting motifSenses disorderOptic nerveGene vector
The invention discloses a recombinant adenovirus associated virus vector containing an ND4 gene expression cassette. A skeleton of the recombinant adenovirus associated virus vector is pAAV9, and theND4 gene expression cassette contains a human ND4 gene or an optimized human ND4 gene. The invention also discloses a preparation method and application of the recombinant adenovirus associated virusvector. According to the preparation method, pAAV9 is used as a gene vector of ND4, and when ND4 is transduced into eyes of a patient, the expression amount on the retina is higher while the safety isensured, the higher transduction efficiency and efficient expression capability are achieved, and the optic nerve cell infection capability is stronger. When the recombinant adenovirus associated virus vector is prepared into a vitreous cavity injection medicine, the effect of the gene in Leber's gene therapy can be enhanced, the injection dosage can be reduced, and the healing time can be shortened.
Owner:WUHAN NEUROPHTH BIOTECHNOLOGY LTD CO
Mixed liquor for labeling and labeling method for animals
InactiveCN101497779BReduce the injection doseStrong concealmentOther chemical processesClimate change adaptationSimple componentNon magnetic
The invention relates to mixture indicator and an animal indicating method, belongs to an indicating method, and provides mixture indicator and an animal indicating method adopting the mixture indicator. Raw materials of the mixture indicator comprise magnetic particle and edible oil, wherein the magnetic particle at least contains iron and carbon. The mixture indicator is injected into an objectto be indicated, a detector determines whether the object is indicated or not, and the indicated object is replaced after the indication is completed. Because the raw materials of the mixture indicator have simple component, stable chemical property, easy obtaining of the raw materials, low cost and easy preparation, the injection quantity of the mixture indicator is little, the indicating speed is very high, and the indicating cost is very low. The invention not only influences the indicated object little, but also has higher safety to a human body, has wide range of application, especially the application to living microbe, such as the cultivation of bionts of rabbit fish, amphioxus, loach, bird, and the like, and can be also used as an indicator of a nonmagnetic product (the product without influencing magnetic lines).
Owner:罗士柱
ND4 gene recombinant adenovirus associated virus vector and preparation method and application thereof
InactiveCN112111519AReduce the injection doseShort healing timeSenses disorderPeptide/protein ingredientsOptic nerveGene vector
The invention discloses a recombinant adenovirus associated virus vector containing an ND4 gene expression cassette. A skeleton of the recombinant adenovirus associated virus vector is pAAV8, and theND4 gene expression cassette contains a human ND4 gene or an optimized human ND4 gene. The invention also discloses a preparation method and application of the recombinant adenovirus associated virusvector. According to the preparation method, pAAV8 is used as a gene vector of ND4, and when ND4 is transduced into eyes of a patient, the expression amount on the retina is higher while the safety isensured, the higher transduction efficiency and efficient expression capability are achieved, and the optic nerve cell infection capability is stronger. When the recombinant adenovirus associated virus vector is prepared into a vitreous cavity injection medicine, the effect of the gene in Leber's gene therapy can be enhanced, the injection dosage can be reduced, and the healing time can be shortened.
Owner:WUHAN NEUROPHTH BIOTECHNOLOGY LTD CO
Polysaccharide macromolecular paramagnetic metal complex and synthesis method and application thereof
InactiveCN101619106BIncreased toxicityShort retention timeIn-vivo testing preparationsLymphatic vesselSide chain
Owner:WUHAN INSTITUTE OF TECHNOLOGY
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