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Injectable composition containing tilmicosin and sulfonamides, and preparation process

A technology of sulfonamide drugs and tilmicosin, applied in the field of drugs, can solve the problems of inappropriate and unstable sulfonamide, and achieve the effects of reducing animal pain, low cost, reducing adverse reactions and other safety accidents

Inactive Publication Date: 2014-03-26
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such a large proportion of organic solvents is not suitable for sulfonamides. Most sulfonamides are soluble in water, and high temperature sterilization is very unstable for tilmicosin containing water.

Method used

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  • Injectable composition containing tilmicosin and sulfonamides, and preparation process
  • Injectable composition containing tilmicosin and sulfonamides, and preparation process
  • Injectable composition containing tilmicosin and sulfonamides, and preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Component

[0031]

[0032] The preparation process is:

[0033] (1) First dissolve disodium edetate, sodium citrate and sodium benzoate in 20ml water for injection in sequence, and filter with 0.45μm microporous membrane to obtain solution A.

[0034] (2) Take 10ml of water for injection, dissolve in sodium carboxymethylcellulose and heat to dissolve, then add anhydrous sodium sulfite and Tween-80, stir to dissolve completely, filter with 0.45μm microporous membrane to obtain solution B.

[0035] (3) Pour solution B into solution A, stir and mix well, add sulfamethazine sodium and tilmicosin, and dilute to 100% (V / V) with water for injection to obtain mixed solution C.

[0036] (4) The mixture C is filtered and sterilized through a 0.22 μm microporous membrane, and filled aseptically to obtain Tilmicosin and Sulfamonomethazine Sodium Injection.

Embodiment 2

[0038] Component

[0039]

[0040]

[0041] The preparation process is:

[0042] (1) First dissolve disodium ethylenediaminetetraacetic acid, sodium citrate, potassium dihydrogen phosphate, and sodium formaldehyde sulfoxylate in 20ml water for injection, and filter with 0.45μm microporous membrane to obtain solution A.

[0043] (2) Take 10ml of water for injection, add anhydrous sodium sulfite to dissolve it, leave it at room temperature, add 50ml of water for injection, dissolve in sodium carboxymethyl cellulose and stir evenly, filter with 0.45μm microporous membrane to obtain solution B .

[0044] (3) Pour solution B into solution A, stir and mix well, add sulfamethazine sodium and tilmicosin, and dilute to 100% (V / V) with water for injection to obtain mixed solution C.

[0045] (4) The mixture C is filtered and sterilized through a 0.22 μm microporous membrane, and filled aseptically to obtain Tilmicosin and Sulfamethazine Sodium Injection.

Embodiment 3

[0047] Component

[0048]

[0049] The preparation process is:

[0050] (1) First dissolve disodium edetate, sodium citrate, potassium dihydrogen phosphate and sodium formaldehyde sulfoxylate in 20ml of water for injection, and filter with 0.45μm microporous membrane to obtain solution A.

[0051] (2) Take 10ml of water for injection, add sodium benzoate; then add 50ml of water for injection, dissolve sodium carboxymethyl cellulose and add Tween-80, after stirring, filter with 0.45μm microporous membrane to obtain solution B .

[0052] (3) Pour solution B into solution A, stir and mix well, add sulfamethazine and tilmicosin, and dilute to 100% (V / V) with water for injection to obtain mixed solution C.

[0053] (4) The mixture C is filtered and sterilized through a 0.22 μm microporous membrane, and filled aseptically to obtain Tilmicosin and Sulfamethazine injections.

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Abstract

The invention relates to an injectable composition containing tilmicosin and sulfonamides, and a preparation process thereof. The composition comprises 4.0%-30.0% (W / V) of sulfonamides, 4.0%-20.0% (W / V) of tilmicosin, 0.05%-0.40% (W / V) of antioxidant, 0.01-15% (W / V) of cosolvent, 1.0%-10.0% (W / V) of pH value buffer salt, 0.01%-0.5% (W / V) of preservative and 0.01%-0.04% (W / V) of complexing agent. The injectable composition containing tilmicosin and sulfonamides provided by the invention has the advantages of high drug ingredient content, low usage volume, the alleviation of pain and the reduction of irritation of animals, the reduction of adverse effect and safety accidents caused by an organic solvent, low manufacture cost, simple production and the like. The injectable composition containing tilmicosin and sulfonamides can be used for preventing and treating bacterial mixed infection diseases.

Description

Technical field [0001] The invention relates to an injectable suspension combination containing tilmicosin and sulfa drugs and a preparation process thereof, which are used for preventing and treating bacterial diseases of livestock and poultry, belonging to the technical field of medicines. Background technique [0002] Bacterial diseases of livestock and poultry are a common and frequently-occurring disease in large-scale farms and farmers' breeding processes, and have become a major factor that harms the livestock and poultry breeding industry. Due to the limitations of the application of bacterial vaccines, drug therapy has become an important measure to control bacterial diseases. During the treatment process, due to the abuse and unreasonable use of drugs, bacterial resistance, especially multi-drug resistance, has become increasingly serious. At the same time, a large number of antibacterial drugs remain in livestock and poultry products, which seriously affects the qualit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/706A61K9/10A61P31/04A61K31/635
Inventor 刘桂兰王品一谢玲玲
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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