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Medical inflation and curing bone-forming agent for strengthening vertebral body

A technology of expanding agent and curing agent, applied in the direction of prosthesis, medical science, etc., can solve the problems affecting the long-term stability of vertebral body reinforcement, insufficient bone cement dosage, poor biocompatibility, etc., achieve good bone conduction performance, prevent vertebral Body Collapse, Reduced Likelihood Effects

Inactive Publication Date: 2012-05-02
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the volume of the cavity in BKP is too small, the amount of bone cement injected is insufficient, and the bone cement is limitedly filled in the cavity and cannot form sufficient contact with the surrounding bone, resulting in a significant decrease in the fixation strength.
[0005] 3. PMMA has good mechanical strength as a filler and curing agent, but due to its poor biocompatibility, it does not biocombine with the surrounding bone in the body and is difficult to degrade, resulting in slow formation of new bone in the vertebral body and osteogenesis. Problems such as the limited amount of new bone and the formation of the interface between the new bone and the material seriously affect the long-term stability of the overall strengthening of the vertebral body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The consumption of expansion agent is 10%, the consumption of curing agent is 40%, the consumption of bone forming agent is 30%, and the consumption of distilled water is 20%.

Embodiment 2

[0019] The consumption of expansion agent is 15%, the consumption of curing agent is 35%, the consumption of bone forming agent is 30%, and the consumption of distilled water is 20%.

Embodiment 3

[0021] The consumption of expansion agent is 20%, the consumption of curing agent is 35%, the consumption of bone forming agent is 30%, and the consumption of distilled water is 15%.

[0022] In the foregoing embodiments, the expansion agent is composed of the following raw materials in parts by weight:

[0023] Take calcium sulfoaluminate powder: 600 parts, calcium sulfate powder: 1100 parts, calcium oxide powder: 350 parts and mix them evenly for use; choose calcium phosphate bone cement or calcium sulfate bone cement as the curing agent; choose hydroxyapatite as the bone forming agent.

[0024] The vertebral body strengthening medical expansion and solidification bone forming agent made in this embodiment will form ettringite, that is, calcium sulfoaluminate hydrate, after the expansion agent is mixed with water, and produce volume expansion, and its reaction is as follows:

[0025] C 4 A 3 S+8CaSO 4 +6CaO+96H 2 O→3C 3 A·3CaSO 4 32H 2 o

[0026] The volume change of...

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PUM

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Abstract

The invention discloses a medical inflation and curing bone-forming agent for strengthening a vertebral body, which is prepared by mixing the following components in percentage by weight: 10 to 20 percent of expanding agent, 30 to 40 percent of curing agent, 30 to 40 percent of bone-forming agent and the balance of water, wherein the total weight percentage of the expanding agent, the curing agent, the bone-forming agent and the distilled water is 100 percent. The whole strengthening degree of the vertebral body can be obviously enhanced under an osteoporosis condition; the stability of the vertebral body is improved; the leakage of a filled material is reduced; the distribution uniformity of the filled material in the vertebral body is improved; new bones are promoted to be formed in the vertebral body at the same time; an osteoporosis state is improved; and the clinical treatment effect is effectively improved. The medical inflation and curing bone-forming agent is a vertebral body strengthening material, which is obvious in expansion effect and good in mechanical property and bone-forming effect.

Description

technical field [0001] The invention relates to a medical expansion and curing bone forming agent, in particular to a medical expansion and curing bone forming agent for vertebral body reinforcement used in spinal vertebroplasty, which is mainly used to improve the overall strength of the vertebral body under the condition of osteoporosis. Background technique [0002] With the aging of the population in our country, the incidence of osteoporosis in the population is increasing year by year. Osteoporotic vertebral compression fracture (OVCF) is a common and serious complication of osteoporosis, often causing low back pain, decreased mobility, and even death due to cardiopulmonary dysfunction caused by severe deformation of the thoracolumbar spine. The family brings a heavy financial and spiritual burden. In view of the above problems, scholars at home and abroad have studied and designed a treatment measure for the overall strengthening of the vertebral body and improving t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/02A61L27/50
Inventor 雷伟冯亚非
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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