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A kind of pancreatic cancer dual-targeting polymer magnetic nanoparticles and its preparation method and application

A magnetic nanoparticle and polymer technology, applied in the field of biomedicine, can solve the problems of poor tumor selectivity, weak specificity and imaging ability, and large injection volume of contrast agent in pancreatic cancer, and achieve good biological safety and degradation , reduce toxic and side effects, and highly specific effects

Active Publication Date: 2021-08-17
贵州中医药大学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0016] 2. The hyaluronic acid-vitamin E succinate polymer micelles in the prior art have not been modified by polypeptides, and have the following defects when used in magnetic resonance imaging: 1) The injection volume of the contrast agent is relatively large, which is potentially toxic to the human body Side effects; 2) Poor tumor selectivity for pancreatic cancer; 3) Weak specificity and imaging ability

Method used

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  • A kind of pancreatic cancer dual-targeting polymer magnetic nanoparticles and its preparation method and application
  • A kind of pancreatic cancer dual-targeting polymer magnetic nanoparticles and its preparation method and application
  • A kind of pancreatic cancer dual-targeting polymer magnetic nanoparticles and its preparation method and application

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Embodiment 1

[0091] Dual-targeting polymeric magnetic nanoparticles for pancreatic cancer

[0092] Ingredients: CKAAKN-hyaluronic acid-vitamin E succinate polymer micelles, iron ferric oxide magnetic nanoparticle solution, deionized water.

[0093] Preparation:

[0094] Weigh CKAAKN-hyaluronic acid-vitamin E succinate polymer micelles and dissolve them in deionized water, add oil-soluble ferric iron tetroxide magnetic nanoparticle solution under ultrasonic stirring, stir for 15-25min under ultrasonic, after 45 Rotary evaporation in a water bath at -65°C to obtain targeted polymer magnetic nanoparticles: CKAAKN-hyaluronic acid-vitamin E succinate@USPIO.

Embodiment 2

[0096] Dual-targeting polymeric magnetic nanoparticles for pancreatic cancer

[0097] Ingredients: 40 mg of CKAAKN-hyaluronic acid-vitamin E succinate polymer micelles, 50 μL of ferroferric oxide magnetic nanoparticle solution, and 16 ml of deionized water.

[0098] Preparation:

[0099] Weigh CKAAKN-hyaluronic acid-vitamin E succinate polymer micelles and dissolve them in deionized water, add oil-soluble ferroferric oxide magnetic nanoparticle solution under ultrasonic stirring, stir for 15 minutes under ultrasonic, and place in a water bath at 45°C Rotary evaporation to obtain targeted polymer magnetic nanoparticles: CKAAKN-hyaluronic acid-vitamin E succinate@USPIO.

Embodiment 3

[0101] Dual-targeting polymeric magnetic nanoparticles for pancreatic cancer

[0102] Ingredients: 60 mg of CKAAKN-hyaluronic acid-vitamin E succinate polymer micelles, 150 μL of ferroferric oxide magnetic nanoparticle solution, and 24 ml of deionized water.

[0103] Preparation:

[0104] Weigh CKAAKN-hyaluronic acid-vitamin E succinate polymer micelles and dissolve them in deionized water, add oil-soluble ferric iron tetroxide magnetic nanoparticle solution under ultrasonic stirring, stir under ultrasonic for 25min, and place in a 65°C water bath Rotary evaporation to obtain targeted polymer magnetic nanoparticles: CKAAKN-hyaluronic acid-vitamin E succinate@USPIO.

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Abstract

A dual-targeting polymer magnetic nanoparticle for pancreatic cancer, the magnetic nanoparticle is made of the following components and methods: CKAAKN-hyaluronic acid-vitamin E succinate polymer micelles, ferroferric oxide magnetic nanoparticle solution , deionized water, hyaluronic acid-tocopherol succinate copolymer modified by CKAAKN polypeptide is encapsulated with ultra-small paramagnetic Fe 3 o 4 Made of magnetic nanoparticles, the present invention designs polymer magnetic nanoparticles modified by CKAAKN polypeptides to mimic Wnt protein to specifically bind to pancreatic cancer cell membrane receptors through the Wnt signaling pathway, and at the same time, the surface of tumor cells can also highly express hyaluronic acid Acid receptors——CD44 and hyaluronic acid-mediated automaticity receptors (RHAMM), so they can specifically target pancreatic cancer cells in the early diagnosis of pancreatic cancer, thus providing a specific and imaging method for early diagnosis of pancreatic cancer Dual-targeting MRI contrast agents with enhanced capabilities.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a pancreatic cancer double-targeting polymer magnetic nanoparticle and a preparation method and application thereof. Background technique [0002] At present, the diagnosis of pancreatic cancer is mainly through imaging diagnosis and detection of serum tumor markers. Carbohydrate antigen CA19-9 is still the most widely used serum tumor marker for pancreatic cancer diagnosis and recurrence monitoring in clinical practice, and has a high diagnostic value for pancreatic cancer. Highly expressed and thus lack sufficient specificity. The commonly used imaging detection methods for pancreatic cancer include body surface ultrasound, magnetic resonance imaging (MRI), computed tomography (CT) and positron emission computed tomography (PET), etc. Often helpless, unable to make an accurate diagnosis. Therefore, in order to improve the diagnostic rate and diagnostic level of early pancreatic ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/14A61K49/12A61K49/18A61K47/42A61K47/36
CPCA61K49/12A61K49/14A61K49/1863A61K49/1866
Inventor 汪祖华周英姜成菊宋信莉缪艳燕张永萍陈晓兰朱修良
Owner 贵州中医药大学
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