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Preparation method of synergistic tylosin tartrate soluble powder compound medicine

A technology of tylosin tartrate and compound prescription is applied in the field of compound medicine preparation of synergistic tylosin tartrate soluble powder, which can solve the problems of incomplete curative effect and the like, and achieves long drug effect maintenance time, fast onset of effect, and storage. long term effect

Inactive Publication Date: 2013-11-27
四川联美生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dosage of the injection is accurate and the effect is reliable, unlike the oral medicine that may be affected by digestive juices, food, etc., so that the dose taken cannot fully produce the curative effect

Method used

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  • Preparation method of synergistic tylosin tartrate soluble powder compound medicine
  • Preparation method of synergistic tylosin tartrate soluble powder compound medicine
  • Preparation method of synergistic tylosin tartrate soluble powder compound medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Tylosin tartrate 1g, kanamycin sulfate 1g, trimethoprim 0.2g, citric acid 0.2g, procaine hydrochloride 0.05g.

[0033] Preparation:

[0034] Respectively take trimethoprim and citric acid of the prescribed amount, mix them and pulverize them through a flow energy mill, pass through a 120 mesh sieve, and then deliver them in equal amounts with tylosin tartrate, kanamycin sulfate, and procaine hydrochloride. Addition, mixing evenly, inspection of semi-finished products, packaging, packaging, inspection of finished products, that is to say.

Embodiment 2

[0036] Tylosin tartrate 1g, kanamycin sulfate 1g, trimethoprim 0.2g, succinic acid 0.2g, procaine hydrochloride 0.05g.

[0037] Preparation:

[0038] Weigh respectively the prescribed amount of trimethoprim and succinic acid, mix them and pulverize them through a flow energy mill, pass through a 120-mesh sieve, and then add them with tylosin tartrate, kanamycin sulfate, and pain relieving agents in equal amounts. Mix evenly, inspect the semi-finished product, subpackage, pack, inspect the finished product, and put it into storage.

Embodiment 3

[0040] Tylosin tartrate 1g, kanamycin sulfate 1g, trimethoprim 0.2g, citric acid 0.2g, lidocaine hydrochloride 0.05g.

[0041] Preparation:

[0042] Respectively weigh trimethoprim and citric acid in the prescribed amount, mix them, pass through a flow energy mill, pass through a 150-mesh sieve, and then mix them with tylosin tartrate, kanamycin sulfate, and pain relieving agents in equal increments Uniformity, inspection of semi-finished products, sub-packaging, packaging, inspection of finished products, warehousing, and ready to go.

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Abstract

The invention aims at providing a preparation method of a synergistic tylosin tartrate soluble powder compound medicine. The synergistic tylosin tartrate soluble powder compound medicine has a rapid and definite curative effect on respiratory system infections and complications of livestock and poultry. The preparation method comprises the following steps of: mixing 0.2 part of trimethoprim and 0.2 part of cosolvent, then crushing, and sieving by using a 120 meshes sieve or a finer sieve; and then uniformly mixing with 1 part of tylosin tartrate, 1 part of kanamycin sulfate and 0.05-0.1 part of pain alleviant by an equivalently successive increase method, thus obtaining the synergistic tylosin tartrate soluble powder compound medicine. The cosolvent is citric acid or succinic acid or the mixture of citric acid and succinic acid and the pain alleviant is procaine hydrochloride or lidocaine hydrochloride or the mixture of procaine hydrochloride and lidocaine hydrochloride. The animal synergistic tylosin tartrate soluble powder compound medicine for injection contains three medical components which are tylosin tartrate, kanamycin sulfate and trimethoprim, can be used for solving the problems that the secondary infection cannot be controlled very well during the treatment of mycoplasma infection due to the narrow antibacterial spectrum of the tylosin tartrate, and the trimethoprim is insoluble in water, has a synergistic effect on tylosin tartrate and kanamycin sulfate and has an obvious medicine curative effect.

Description

[0001] This application is a divisional application of the invention patent with the application number: 201210277080.6 and the patent name: "Preparation method of compound synergistic tylosin tartrate for veterinary injection". The original filing date: August 6, 2012. technical field [0002] The invention relates to compound synergistic tylosin tartrate for veterinary injection, or a compound drug called synergistic tylosin tartrate soluble powder. Background technique [0003] Judging from the current development of my country's animal husbandry industry, the current high incidence of respiratory infections in livestock and poultry, serious complications, and great harm to livestock and poultry. Also do not have comparatively desirable therapeutic drug treating both symptoms and root causes on the market now. Through investigation and research on the domestic and international markets, it is found that the market is in urgent need of a drug that has a stable drug effect,...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/14A61P31/04A61P29/00A61P11/00A61K31/7036A61K31/505A61K31/167A61K31/245
Inventor 陈益德胡学全周可刚何丽花刘亚
Owner 四川联美生物药业有限公司
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