Preparation method of granules for diminishing inflammation, relieving pain and promoting gastric mucosa repair

Abstract

The invention relates to a preparation method of granules for diminishing inflammation, relieving pain and promoting gastric mucosa repair. The preparation method comprises the following steps of: crushing procaine hydrochloride and cane sugar till the particle sizes of the two components can be 80 meshes; dosing and weighing, wherein gelatin is taken, and the weight ratio of gentamycin sulfate (calculated by anhydride) to procaine hydrochloride (calculated by anhydride) to vitamin B12 to the cane sugar is 20mg: 0.1g: 0.02mg: 4.81g; preparing a binding agent; granulating, wherein the procaine hydrochloride and the cane sugar are sequentially poured into a fluidized bed drying granulator, solution of the gentamycin sulfate and the vitamin B12 is sprayed into the mixture after the procaine hydrochloride and the cane sugar are fully mixed for 15 minutes, then aqueous solution of the gelatin is taken as the binding agent for spraying fluidized granulation, the granulation temperature is controlled in a range of 50+ / -5 DEG C, the drying temperature is controlled in a range of 65+ / -5 DEG C, the drying lasts for 20 minutes and stops after the granules are formed and then the granules are obtained; granulating; and totally mixing the granules. The preparation method has the advantage of obtaining the granules with good quality.

Description

technical field [0001] The invention relates to a preparation method of granules, in particular to a preparation method of anti-inflammatory, pain-relieving and gastric mucosa repair-promoting granules. Background technique [0002] At present, there are a large number of gentamicin, procaine and vitamin B for sale in the market 12 Granules (Gentamycin Sulfatc, procaine Hydrochloride and Vitamin B 12 Granules), however a different brand of gentamicin procaine vitamin B 12 The medical effects of granules are very different. On the one hand, there are differences in the ratio, and on the other hand, there are differences in the production process. The invention provides a kind of gentamicin procaine vitamin B with better production quality 12 The production method of granules, gentamicin procaine vitamin B 12 The granules can reduce inflammation, relieve pain, and promote the repair of gastric mucosa. They are mainly used for chronic and superficial gastritis, and are als...

AI Technical Summary

Problems solved by technology

[0002] At present, there are a large number of gentamicin, procaine and vitamin B for sale in the market 12 Granules (Gentamycin Sulfatc, procaine Hydrochloride and Vitamin B 12 Granules), however a different brand of gentamicin procaine vitamin B 12 The medical effects of granules are very different. On the one hand, there are differences in the ratio, and on the other hand, there are differences in the production process.

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