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Compound tablet for treating gastritis and preparation thereof

A compound tablet, gastritis technology, applied in the field of gentamicin procaine vitamin B12 tablets and preparation, can solve the problems of unfavorable gastric mucosa repair patients taking, affecting drug release speed, affecting anti-inflammatory and pain relief, etc. The effect of spasm of external smooth muscle, rapid release, strong killing effect

Inactive Publication Date: 2005-10-12
海南康福中正发展有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, similar marketed products mainly include capsules and granules, but the capsule shell can contain up to 15% of water, and gentamicin is very easy to absorb moisture, which will affect the quality of the drug, and the capsule shell will affect the quality of the drug to a certain extent. The release speed affects the anti-inflammatory and analgesic effects; the granules contain more sugar, which is not conducive to the repair of gastric mucosa and some patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] (1) Prescription

[0012] Gentamicin Sulfate 10 million units

[0013] Procaine Hydrochloride 50g

[0014] Vitamin B 12 0.01g

[0015] Lactose 55g

[0016] Microcrystalline Cellulose 65g

[0017] Hypromellose 12g

[0018] Micronized silica gel 2.5g

[0019] Talc powder 1.5g

[0020] 1000 pieces

[0021] (2) Process

[0022] The main drug is finely ground and passed through a 100-mesh sieve, and the auxiliary materials are passed through a 80-mesh sieve. The gentamycin sulfate, procaine hydrochloride, lactose, microcrystalline cellulose and 50% hydroxypropyl cellulose of prescription quantity are fully mixed with equal increasing method, and passed through a 60-mesh sieve. The soft material is made of ethanol, passed through a 40-mesh sieve, dried below 80°C, and granulated through a 30-mesh sieve. Another prescribed amount of B vitamins 12 1. The remaining hydroxypropyl cellulose is fully mixed with the method of equal increase, and then mixed w...

Embodiment 2

[0024] (1) Prescription

[0025] Gentamicin Sulfate 10 million units

[0026] Procaine Hydrochloride 50g

[0027] Vitamin B 12 0.01g

[0028] Lactose 58g

[0029] Microcrystalline Cellulose 70g

[0030] Hypromellose 20g

[0031] Micronized silica gel 2.5g

[0032] Talc powder 1.5g

[0033] 1000 pieces

[0034] (2) Process

[0035] The main drug is finely ground and passed through a 100-mesh sieve, and the auxiliary materials are passed through a 80-mesh sieve. The gentamycin sulfate, procaine hydrochloride, lactose, microcrystalline cellulose and 50% hydroxypropyl cellulose of prescription quantity are fully mixed with equal increasing method, and passed through a 60-mesh sieve. The soft material is made of ethanol, passed through a 40-mesh sieve, dried below 80°C, and granulated through a 30-mesh sieve. Another prescribed amount of B vitamins 12 1. The remaining hydroxypropyl cellulose is fully mixed with the method of equal increase, and then mixed w...

Embodiment 3

[0037] (1) Prescription

[0038] Gentamicin Sulfate 10 million units

[0039] Procaine Hydrochloride 50g

[0040] Vitamin B 12 0.01g

[0041] Lactose 75g

[0042] Microcrystalline Cellulose 90g

[0043] Hypromellose 60g

[0044] Micronized silica gel 2.5g

[0045] Talc powder 1.5g

[0046] 1000 pieces

[0047] (2) Process

[0048] The main drug is finely ground and passed through a 100-mesh sieve, and the auxiliary materials are passed through a 80-mesh sieve. The gentamycin sulfate, procaine hydrochloride, lactose, microcrystalline cellulose and 50% hydroxypropyl cellulose of prescription quantity are fully mixed with equal increasing method, and passed through a 60-mesh sieve. The soft material is made of ethanol, passed through a 40-mesh sieve, dried below 80°C, and granulated through a 30-mesh sieve. Another prescribed amount of B vitamins 12 1. The remaining hydroxypropyl cellulose is fully mixed with the method of equal increase, and then mixed w...

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PUM

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Abstract

A compound medicine in the form of tablet for treating gastritis contains proportionally gentamycin sulfate, procaine hydrochloride, VB12 and medicinal additives.

Description

technical field [0001] The invention belongs to pharmaceutical preparations and relates to the technical field of medicine, specifically a kind of gentamicin procaine vitamin B used for the treatment of gastritis 12 Tablets and methods of preparation. Background technique [0002] Gentamicin sulfate is an aminoglycoside antibiotic, which has a strong inhibitory effect on Hp and can effectively cut off the source of the disease. Procaine hydrochloride can seal the nerve endings on the surface of the damaged mucosa, block the stimulation of the lesion to the central nervous system, and relieve pain quickly; at the same time, it has a vasodilator effect, which can dilate the blood vessels of the gastric mucosa and improve microcirculation. The blood volume increases, the repair function is enhanced, and inflammation subsides; another study proves that procaine hydrochloride still has a certain effect of promoting gastrointestinal motility, and can relieve the symptoms of delay...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/166A61K31/7036A61K31/714A61P1/04
Inventor 汤小东汤旭东
Owner 海南康福中正发展有限公司
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