30results about How to "Non-genotoxic" patented technology

The artificial carbon humeral prosthesis consists of carbon humeral ball and carbon humeral handle, the humeral ball has fixing slot in its bottom and the humeral handle comprises fixing column and humeral handle rod. The fixing column is embedded into the fixing slot, and the axis of the humeral ball joint surface and the axis of the humeral handle rod form one angle of 135-145 deg. The humeral carbon ball of the present invention has high mechanical strength and high chemical stability, no cell toxicity, no irritability, no genetic toxicity, good biocompatibility, elastic modulus near that of bone, osteoplastic activity and lubricating property. The humeral handle has high mechanical strength, high corrosion resistance and good biocompatibility. The present invention is suitable for use in case of replacing humerus.

The invention discloses a medicinal absorbable and degradable biological anti-adhering material. The main component of the biological anti-adhering material is chitosan and the chitosan is a pure natural extract, so the biological anti-adhering material has low cost and rich source and does not produce any toxic or side effect during use. The anti-adhering material is a copolymer of the followingraw materials in part by weight: 10 to 75 percent of chitosan, 0 to 60 parts of hyaluronic acid, 0 to 30 parts of polyethylene glycol and 1 to 45 parts of polylactic acid. The biological anti-adhering material placed in vivo for 7 to 30 days can be fully degraded and absorbed and does not coagulate into bulk foreign matters. Because of high safety and effectiveness compared with the traditional material, most patients are willing to accept the medicinal anti-adhering material of the invention; and the operating process is simpler, and the medicinal personnel of each level can operate and accurately use the medicinal anti-adhering material after training.

The invention discloses a post-operation absorbable anti-adhesion material for cardiac surgery and a film prepared from the material. The material is prepared from the following ingredients in parts by weight: 45 to 85 parts of chitosan, 5 to 25 parts of gelatin, 5 to 15 parts of glycerol, 5 to 20 parts of collagen and 5 to 20 parts of silk fibroin. A preparation method of an isolation film comprises the following steps of preparing 90 kg of 15-weight-percent chitosan mixed solution; preparing 50 kg of silk fibroin stock solution with the concentration being 10 to 25 percent; mixing the mixedsolution and the silk fibroin stock solution to the concentration being 10 to 20 weight percent by an acetic acid solution with the concentration being 2 to 15 weight percent; performing filtering; performing still standing for 5 to 24 hours; performing defoaming; after the defoaming, putting the materials into a baking oven being 40 to 70 DEG C for drying, thus obtaining the film. The anti-adhesion film prepared by the method is used for the cardiac surgery, has good biocompatibility, is absorbable and degradable, and can prevent the heart and peripheral tissue adhesion after the surgery, protect the heart function, and avoid secondary thoracotomy difficulty increase and occurrence of complications such as hemorrhea caused by adhesion.

The invention discloses pure traditional Chinese medicine health food assisting in reducing blood sugar and a preparation method of the pure traditional Chinese medicine health food. The health food is prepared by the following pure traditional Chinese medicine raw materials in parts by weight: 10-15 parts of radix puerariae, 6-14 parts of cortex lycii radicis, 6-14 parts of mulberry leaf, 4-10 parts of acanthopanax and 4-10 parts of fenugreek. The preparation method comprises the steps of raw material pretreatment, alcohol extraction, water extraction, thick paste mixing, vacuum drying, grinding, filling, polishing and packaging sequentially to prepare an oral capsule preparation. According to the food and the method, the composition is reasonable, the effect is balanced, the entire adjustment advantage is exerted, the functions of internal organs all over a body are adjusted, and the pure traditional Chinese medicine health food can well assist in reducing the blood sugar. The food has no adverse effect, is good in safety after long-term use, and cannot generate dependence. The preparation technology is simple, the cost is lower, and industrial production can be realized.

The invention relates to 11,20-dicarbonyl Jiyuan oridonin and its L-amino acid-14-ester trifluoroacetate and its preparation method and use, belonging to the field of pharmaceutical compounds. Its preparation method: take Jiyuan Rubescensine A as raw material, and oxidize it with Jones reagent to obtain 11,20-dicarbonyl Jiyuan Rubescensin A, and its structure is as follows: then combine it with N-BOC-L- Amino acid undergoes 14-position esterification reaction to obtain N-BOC-L-amino acid-11,20-dicarbonyl Jiyuan Rubescensin ester (III), and then removes the BOC protecting group in trifluoroacetic acid to form a salt to obtain L‑amino acid‑14‑(11,20‑dicarbonyl oridonin) ester trifluoroacetate. It has the following general formula: this type of compound has good stability and anti-tumor activity. and other anticancer drugs provide the basis.

The invention discloses a medical silver-carrying gauze. The modified polyamide complex silver is loaded in the gauze; the modified polyamide complex silver is mainly composed of silver ions and the amino group of the modified polyamide complexed. The amino group of an amide exists only in the interior of its molecular structure. The silver ions are wrapped in the modified polyamide, and then tightly combined with the gauze, so that the silver ions can be fixed and released in a small amount, and the release is stable; the release time of silver ions is more than 8 days, and the release is lasting; the antibacterial performance is excellent; It is non-nano-silver, non-irritating, non-sensitizing, non-acute and chronic systemic toxicity, non-genotoxic, and has good biocompatibility. The invention also discloses the preparation method of the medical silver-carrying gauze, which has the advantages of simple operation, low cost, environmental friendliness, high safety performance, and no new impurity elements are introduced.

The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for relieving physical fatigue and / or improving anoxia endurance, and a preparing method thereof. The traditional Chinese medicine composition for relieving physical fatigue and / or improving anoxia endurance is prepared from fresh ginger or extract thereof, herba rhodiolae or extract thereof and radix astragali or extract thereof based on the mass ratio of (1.5-4.5):(0.5-2.5):1. The traditional Chinese medicine composition has the healthcare functions of relieving physical fatigue, improving anoxia endurance and relieving chronic fatigue syndrome, and is reasonable in composition, remarkable in effect and free of genotoxicity.

The invention discloses an epidural-subcutaneous buried type analgesia pump with an anti-infection function. The epidural-subcutaneous buried type analgesia pump comprises a base (2). The base (2) is internally provided with a cavity. The cavity is composed of a large circular cavity body (21) and a small circular cavity body (22). The large circular cavity body (21) is located over the small circular cavity body (22). The lower end of a silica gel cover assembly (4) is connected with the large circular cavity body (21) in a seamless mode. The small circular cavity body (22) is internally provided with a barrel-shaped antibacterial coating inner container (3). A guide pipe assembly (1) is only communicated with the small circular cavity body (22). The antibacterial coating inner container (3) is manufactured by the following steps that raw materials are obtained by mixing clay powder and medical paraffin according to the mass ratio of 100:5-20; the raw materials are made into the required barrel shape through a die, pressureless sintering at 1600 DEG C to 1700 DEG C is conducted for 2 to 4 hours, and the inner container is obtained; the surface of the inner container is loaded with an antibacterial coating.

The invention discloses a purification method for reducing the protein content in sodium hyaluronate and its derivatives. The specific preparation process includes the following process steps: adding a specific type of protein complexing agent to the crude product solution of sodium hyaluronate and its derivatives, filtering The insoluble matter is removed, and pure sodium hyaluronate and its derivatives are obtained by alcohol precipitation. The present invention has a good effect on removing the protein in sodium hyaluronate and its derivative products through the function of protein complexing agent, and can reduce the protein content in sodium hyaluronate and its derivative products to below 0.015%, thus significantly It reduces the risk of allergic reactions caused by heterologous proteins to sodium hyaluronate and its derivative preparations, and has extremely high clinical application value; the method of the invention has simple process, low cost, easy operation, good economy, and is more suitable for industrialization Production; the sodium hyaluronate and its derivatives obtained in the present invention have high purity, good safety, less allergic reactions, and bring maximum benefits to patients.

The invention relates to a health food with auxiliary blood sugar and blood lipid lowering functions. The health food is characterized in that: each 1000 granules of capsules comprise 90-110g of purified konjak powder, 72-88g of extracts from acanthopanax, 54-66g of extracts from gynostemma pentaphylla, and 54-66g of extracts from green tea. The weight of contents in each granule of the capsule is 0.3g, and each 100g of the contents comprises 33.67-40.33g of glucomannan, 10.01-11.99g of tea polyphenol, and 3.01-3.59g of total saponins. The health food which is an oral capsule preparation and has the advantages of accurate efficacy, rapid action, safety and reliability, and small taking dosage is convenient for carrying and long-term taking; and the health food which simultaneously has dual auxiliary blood sugar and blood lipid lowering functions is helpful for rehabilitation of patients who only have hyperglycemia or hyperlipidemia, or simultaneously have hyperglycemia and hyperlipidemia, and also allows concurrent cardiovascular and cerebrovascular diseases and the like of diabetes and hyperlipidemia to be prevented. The health food of the invention is different from simple blood sugar and blood lipid products in the recent market.

The invention discloses a medical oviduct stent device, which comprises a stent and an accessory, wherein the accessory comprises a guide tube and a guide wire; the tail end of the guide tube is provided with a stent prepared from chitosan and glycerol. A preparation method of the stent comprises the following steps of preparing 20 weight percent of chitosan acetic acid solution by an acetic acidsolution with the concentration being 10 to 30 weight percent; after the glycerol adding, performing mixing and filtering; performing still standing for 24 hours for defoaming; injecting the materialsinto a mod; putting the materials into a baking oven being 40 to 70 DEG C; performing drying, to obtain the stent. The guide tube has the length being 40 to 45 cm, the outer diameter being 1.5 to 3 mm, and the inner diameter being about 0.5 to 2 mm; the tail end 1 to 3 cm is in a cone shape; the guide wire has the length of 45 to 50 cm, and the diameter is 0.6 to 0.8 mm. By using the technical scheme provided by the invention, the preparation process is simple; the forms are various; convenience and practicability are realized; the stent has the characteristics that good biocompatibility andabsorbable degradation performance are realized; the device is favorable for wound surface restoration; the operation is simple and convenient, and the like. The oviduct recurrent obstruction is avoided; the postoperative intrauterine pregnancy rate is improved.

The invention provides a biodegradable material for preventing postoperative adhesion. A method for preparing the biodegradable material comprises the steps of adding a cross-linker into a 0.5-2.5% sodium hyaluronate solution, carrying out cross-linking reaction at the temperature of 0-80 DEG C, dialyzing a mixed solution in water after the reaction is ended, and drying the dialyzed solution, thereby obtaining the biodegradable material. The degradable biological material prepared by the method has good physical and chemical properties and biocompatibility, and can be used for effectively preventing the occurrence of postoperative adhesion.

The invention discloses a preparation method of high-purity sugammadex sodium, which is prepared by using phosphoinositol esters and derivatives thereof. The specific process is as follows: adding a specific type of protective agent to the crude product of sugammadex sodium; Under protection, the pure product of sugammadex sodium was obtained by recrystallization. Wherein, the protective agent is selected from inositol phosphate and derivatives thereof, such as inositol hexaphosphate and its salt or ester; partial degradation products of inositol hexaphosphate such as inositol pentaphosphate and inositol tetraphosphate , inositol triphosphate, inositol diphosphate, inositol monophosphate and one or more of the aforementioned substances and their salts or esters, or a mixture of two or more in any proportion. The method is easy to operate, high in product purity, good in safety, less in allergic reactions, good in economy, and more suitable for industrialized production.