30results about How to "Non-genotoxic" patented technology

The invention relates to a traditional Chinese medicine composition for relieving fatigue and improving anoxia endurance, and a preparation method thereof. The traditional Chinese medicine composition is prepared from rhodiola root, milk vetch and safflower. The traditional Chinese medicine composition for relieving fatigue and improving anoxia endurance regulates qi and blood weakness of a human body and dysfunction of the viscera by invigorating qi, promoting blood circulation and strengthening the body surface resistance, thereby achieving the effects on relieving physical fatigue and improving anoxia endurance. The traditional Chinese medicine composition provided by the invention does not have genetic toxicity and has better prevention and treatment effects.

The invention discloses a traditional Chinese medicine health care food for relieving physical fatigue and a preparation method thereof. The health care food is prepared by five pure traditional Chinese medicine raw materials including flatstem milkvetch seed, semen cuscutae, herba epimedii, rhizoma polygonati and American ginseng. The raw materials are as follows in parts by weight: 20-50 parts of flatstem milkvetch seed, 20-40 parts of semen cuscutae, 5-20 parts of herba epimedii, 5-20 parts of rhizoma polygonati and 1-6 parts of American ginseng. The raw materials are orderly treated by preparation methods such as pretreatment, alcohol extraction, water extraction, thick paste mixing, spray-drying, crushing, mixing, filling, polishing, packing and the like so as to obtain an oral capsule preparation. The traditional Chinese medicine health care food disclosed by the invention has reasonable components and balanced effect, plays an overall regulation advantage and regulates the function of each visceral organ in the whole body, so the traditional Chinese medicine health care food is a good pure traditional Chinese medicine health care food that is helpful to relieve physical fatigue, also causes no untoward effects, has high safety even being taken for a long time, and causes no dependency. The preparation method related to the invention is simple, low in cost and capable of realizing industrial production.

The artificial carbon humeral prosthesis consists of carbon humeral ball and carbon humeral handle, the humeral ball has fixing slot in its bottom and the humeral handle comprises fixing column and humeral handle rod. The fixing column is embedded into the fixing slot, and the axis of the humeral ball joint surface and the axis of the humeral handle rod form one angle of 135-145 deg. The humeral carbon ball of the present invention has high mechanical strength and high chemical stability, no cell toxicity, no irritability, no genetic toxicity, good biocompatibility, elastic modulus near that of bone, osteoplastic activity and lubricating property. The humeral handle has high mechanical strength, high corrosion resistance and good biocompatibility. The present invention is suitable for use in case of replacing humerus.

The invention discloses a medicinal absorbable and degradable biological anti-adhering material. The main component of the biological anti-adhering material is chitosan and the chitosan is a pure natural extract, so the biological anti-adhering material has low cost and rich source and does not produce any toxic or side effect during use. The anti-adhering material is a copolymer of the following raw materials in part by weight: 10 to 75 percent of chitosan, 0 to 60 parts of hyaluronic acid, 0 to 30 parts of polyethylene glycol and 1 to 45 parts of polylactic acid. The biological anti-adhering material placed in vivo for 7 to 30 days can be fully degraded and absorbed and does not coagulate into bulk foreign matters. Because of high safety and effectiveness compared with the traditional material, most patients are willing to accept the medicinal anti-adhering material of the invention; and the operating process is simpler, and the medicinal personnel of each level can operate and accurately use the medicinal anti-adhering material after training.

The invention discloses a medical absorbable polysaccharide composite material and application thereof. According to the medical absorbable polysaccharide composite material, starch with poor water absorbability is used as one material in the polysaccharide composite material; furthermore, a polysaccharide material with good water absorbability is added; the composite polysaccharide material is obtained through directly mixing, or through adding water, uniformly mixing and then carrying out freeze drying, without the need of cross-linking reaction. The material has the advantages of high waterabsorption rate, rapid water absorption speed, higher gel strength, good biocompatibility and the like, and can be directly used on wound surfaces with blood and for stopping bleeding of body surfaces, tissue organs in inner parts of bodies and in body cavities; the material can be used for rapidly stopping bleeding, can be absorbed by human bodies and has a sticky plugging effect. The material also can be further used as a post-operative anti-adhering material, a tissue healing promoting material, a surgical sealant, a wound suture-free tissue adhesive, a tissue filling material and a tissuedebridement material.

The invention relates to a traditional Chinese medicine composition and application of the traditional Chinese medicine composition to preparing medicines or healthcare products in the aspects of assistance in reducing blood lipid and improving memory. The traditional Chinese medicine composition comprises folium ginkgo or extract of the folium ginkgo, radix puerariae or extract of the radix puerariae, fructus crataegi or extract of the fructus crataegi, grape seeds or extract of the grape seeds, rhizoma zingiberis recens or extract of the rhizoma zingiberis recens and green tea or extract ofthe green tea. A weight ratio of the folium ginkgo or the extract of the folium ginkgo to the radix puerariae or the extract of the radix puerariae to the fructus crataegi or the extract of the fructus crataegi to the grape seeds or the extract of the grape seeds to the rhizoma zingiberis recens or the extract of the rhizoma zingiberis recens to the green tea or the extract of the green tea is 0.5-8.0:0.8-4.8:0.9-4.8:0.3-3.5:0.5-2.5:1. The traditional Chinese medicine composition and the application have the advantages that the traditional Chinese medicine composition comprises reasonable components, has functions of reducing the blood lipid and improving the memory, is free of genetic toxicity and can be effectively applied to preparing the medicines or the healthcare products in the aspects of assistance in reducing the blood lipid and improving the memory, and obvious effects can be realized by the traditional Chinese medicine composition.

The invention discloses medical silver-loaded gauze. Modified polyamide complexing silver is loaded in the gauze. The modified polyamide complexing silver is mainly formed by complexing silver ions and amino groups of modified polyamide, and the amino groups of the modified polyamide only exist in the molecular structure of the modified polyamide. The silver ions are wrapped in the modified polyamide and are further tightly combined with the gauze without falling off, so that the silver ions can be fixedly released in a trace manner, and the release is stable; the release duration of silver ions is 8 days or more, and the release is lasting; the antibacterial performance is excellent; and the non-nano silver is adopted, so that no stimulation, no sensitization, no acute and chronic systemic toxicity and no genetic toxicity are realized, and good biocompatibility is realized. The invention further discloses a preparation method of the medical silver-loaded gauze. The preparation method is easy to operate, low in cost, environmentally friendly and high in safety performance, and new impurity elements cannot be introduced.

The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for relieving physical fatigue and / or improving anoxia endurance, and a preparing method thereof. The traditional Chinese medicine composition for relieving physical fatigue and / or improving anoxia endurance is prepared from fresh ginger or extract thereof, herba rhodiolae or extract thereof and radix astragali or extract thereof based on the mass ratio of (1.5-4.5):(0.5-2.5):1. The traditional Chinese medicine composition has the healthcare functions of relieving physical fatigue, improving anoxia endurance and relieving chronic fatigue syndrome, and is reasonable in composition, remarkable in effect and free of genotoxicity.

The invention discloses pure traditional Chinese medicine health food assisting in reducing blood sugar and a preparation method of the pure traditional Chinese medicine health food. The health food is prepared by the following pure traditional Chinese medicine raw materials in parts by weight: 10-15 parts of radix puerariae, 6-14 parts of cortex lycii radicis, 6-14 parts of mulberry leaf, 4-10 parts of acanthopanax and 4-10 parts of fenugreek. The preparation method comprises the steps of raw material pretreatment, alcohol extraction, water extraction, thick paste mixing, vacuum drying, grinding, filling, polishing and packaging sequentially to prepare an oral capsule preparation. According to the food and the method, the composition is reasonable, the effect is balanced, the entire adjustment advantage is exerted, the functions of internal organs all over a body are adjusted, and the pure traditional Chinese medicine health food can well assist in reducing the blood sugar. The food has no adverse effect, is good in safety after long-term use, and cannot generate dependence. The preparation technology is simple, the cost is lower, and industrial production can be realized.

The invention discloses a preparation method of high-purity sugammadex sodium. The high-purity sugammadex sodium is prepared from inositol phosphate and derivatives thereof. The specific process comprises the following steps of adding a specific type of protective agent into a crude sugammadex sodium product, and performing recrystallizing under the protection of inert gas to obtain a pure sugammadex sodium product, wherein the protective agent is selected from the inositol phosphate and the derivatives thereof, such as inositol hexaphosphate and salts or esters thereof, partial degradation products of the inositol hexaphosphate, such as inositol pentaphosphate, inositol tetraphosphate, inositol triphosphate, inositol diphosphate and inositol monophosphate, and one or a mixture of two or more of the above-mentioned substances and salts or esters thereof in any proportion. The method is simple and convenient to operate, high in product purity, good in safety, few in anaphylactic reaction, good in economical efficiency and more suitable for industrial production.

The invention discloses a medical antibacterial wound dressing which is prepared by copolymerizing the following raw materials in parts by weight: 10-55 parts of chitosan, 1-60 parts of hyaluronic acid, 5-10 parts of sodium carboxymethylcellulose, 1-35 parts of gelatin, 1-20 parts of polyethylene glycol, 1-30 parts of glycerin and 1-20 parts of polyoxyethane. When in use, the wound dressing is fixed by a semipermeable thermoplastic polyurethane elastomer (TPU) waterproof backing. The prepared wound dressing is simple in preparation process, diversified in shape, convenient, practical, good in moisture penetrability, moisture absorptivity and biocompatibility, low in replacement frequency and suitable for wound protection of burn injury, scald injury and traumatic wounds.

The invention discloses a non-operative adhesive agent. A blocking material of the adhesive agent adopts a chitosan medical rod-shaped material and a wrapping material of the adhesive agent adopts a chitosan medical film material to wrap an alpha-cyanoacrylate adhesive; the chitosan medical rod-shaped material is a copolymer of the following raw materials in part by weight: 10 to 75 parts of chitosan, 1 to 45 parts of hyaluronic acid, 0 to 45 parts of polylactic acid and 0 to 20 parts of gelatin; and the chitosan medical film material is a copolymer of the following raw materials in part by weight: 10 to 50 parts of chitosan, 1 to 60 parts of hyaluronic acid, 0 to 35 parts of glycerol and 0 to 45 parts of polylactic acid. The invention also discloses a preparation method of the non-operative adhesive agent. The adhesive agent is a purely natural extract, has low cost and rich source and cannot generate any toxic or side effects when in use. The application of the adhesive to implementation of contraception has the advantages of no operation, little pain and small side effect and cannot influence work and life.

The invention discloses a medicinal absorbable and degradable biological anti-adhering material. The main component of the biological anti-adhering material is chitosan and the chitosan is a pure natural extract, so the biological anti-adhering material has low cost and rich source and does not produce any toxic or side effect during use. The anti-adhering material is a copolymer of the followingraw materials in part by weight: 10 to 75 percent of chitosan, 0 to 60 parts of hyaluronic acid, 0 to 30 parts of polyethylene glycol and 1 to 45 parts of polylactic acid. The biological anti-adhering material placed in vivo for 7 to 30 days can be fully degraded and absorbed and does not coagulate into bulk foreign matters. Because of high safety and effectiveness compared with the traditional material, most patients are willing to accept the medicinal anti-adhering material of the invention; and the operating process is simpler, and the medicinal personnel of each level can operate and accurately use the medicinal anti-adhering material after training.

The invention belongs to the technical field of a degradable high molecular medical material, and particularly relates to a medical degradable high molecular antibacterial composite material. The medical degradable high molecular antibacterial composite material is prepared from the following raw materials of polypropylene glycol glutarate with the intrinsic viscosity being 1.138dL / g, dimethylchlorosilane, 3-(2-pyridine disulfide) propanoic acid N-hydroxysuccinimide eater, hydroxyl compound, royal jelly acid, toughening agents and biomass extracting materials. Compared with the prior art, themedical degradable high molecular antibacterial composite material has the following advantages that through the addition of an extraction material A, the cooperated effect can be achieved with royaljelly; the antibacterial performance of the composite material can be improved; certain temperature resistance is ensured; through the reasonable matching with other raw materials, the stretching resistant performance with the composite material is ensured; the royal jelly can improve the toughness of the composite materials; the use performance of medical tablecloth is further ensured; meanwhile,the effective degradation can be realized; the environment pollution is avoided; the obtained polyester polymer materials are sterile and do not have heating sources; the hemolysis ratio is smaller than 5 percent; no anaphylactic reaction exists; no genetic toxicity exists; the safe use is realized.

The invention relates to the technical field of biomedical materials, and particularly discloses anti-adhesion gel for a postoperative uterine cavity as well as a preparation method and application ofthe anti-adhesion gel. The anti-adhesion gel for the postoperative uterine cavity is prepared from the following components in percentage by weight of 0.1-1.0 percent of gellan gum, 0.2-2 percent offunctional auxiliary materials, 2-6 percent of osmotic pressure regulator and the balance of water for injection. The anti-adhesion gel for the postoperative uterine cavity is ionic phase-change gellan gum, and when the anti-adhesion gel is injected into the uterine cavity of a body, the viscosity is relatively low, the fluidity and the adhesiveness are good, and coating is uniform and rapid. After contact with uterine cavity liquid and ion phase change occurs, curing time is short, relatively high strength, elasticity and toughness are achieved, in-vivo adhesion can be maintained for 14 daysor longer, a good anti-adhesion effect is achieved in the recovery period, and the gel is gradually and safely degraded after 14 days and is absorbed or discharged by the human body.

The invention discloses pure traditional Chinese medicine health food assisting in reducing blood sugar and a preparation method of the pure traditional Chinese medicine health food. The health food is prepared by the following pure traditional Chinese medicine raw materials in parts by weight: 10-15 parts of radix puerariae, 6-14 parts of cortex lycii radicis, 6-14 parts of mulberry leaf, 4-10 parts of acanthopanax and 4-10 parts of fenugreek. The preparation method comprises the steps of raw material pretreatment, alcohol extraction, water extraction, thick paste mixing, vacuum drying, grinding, filling, polishing and packaging sequentially to prepare an oral capsule preparation. According to the food and the method, the composition is reasonable, the effect is balanced, the entire adjustment advantage is exerted, the functions of internal organs all over a body are adjusted, and the pure traditional Chinese medicine health food can well assist in reducing the blood sugar. The food has no adverse effect, is good in safety after long-term use, and cannot generate dependence. The preparation technology is simple, the cost is lower, and industrial production can be realized.

The invention discloses a medical silver-carrying gauze. The modified polyamide complex silver is loaded in the gauze; the modified polyamide complex silver is mainly composed of silver ions and the amino group of the modified polyamide complexed. The amino group of an amide exists only in the interior of its molecular structure. The silver ions are wrapped in the modified polyamide, and then tightly combined with the gauze, so that the silver ions can be fixed and released in a small amount, and the release is stable; the release time of silver ions is more than 8 days, and the release is lasting; the antibacterial performance is excellent; It is non-nano-silver, non-irritating, non-sensitizing, non-acute and chronic systemic toxicity, non-genotoxic, and has good biocompatibility. The invention also discloses the preparation method of the medical silver-carrying gauze, which has the advantages of simple operation, low cost, environmental friendliness, high safety performance, and no new impurity elements are introduced.

The invention discloses a purification method for reducing the protein content in sodium hyaluronate and derivatives thereof. The specific preparation process comprises the following process steps of adding a specific type of protein complexing agent into a sodium hyaluronate and derivative crude product solution, filtering to remove insoluble substances, and carrying out alcohol precipitation to obtain pure products of sodium hyaluronate and derivatives thereof. Under the action of the protein complexing agent, the method has a very good effect of removing proteins in sodium hyaluronate and derivative products thereof, and the content of the proteins in the sodium hyaluronate and the derivatives thereof can be reduced to 0.015% or below, so that the risk of anaphylactic reaction of sodium hyaluronate and derivative preparations thereof caused by heterologous proteins is remarkably reduced; the clinical application value is extremely high; the method disclosed by the invention is simple in technological process, low in cost, easy to operate, good in economical efficiency and more suitable for industrial production; the sodium hyaluronate and the derivative thereof obtained by the invention are high in purity, good in safety and less in anaphylactic reaction, and bring maximum benefits to patients.

The invention discloses an epidural-subcutaneous buried type analgesia pump with an anti-infection function. The epidural-subcutaneous buried type analgesia pump comprises a base (2). The base (2) is internally provided with a cavity. The cavity is composed of a large circular cavity body (21) and a small circular cavity body (22). The large circular cavity body (21) is located over the small circular cavity body (22). The lower end of a silica gel cover assembly (4) is connected with the large circular cavity body (21) in a seamless mode. The small circular cavity body (22) is internally provided with a barrel-shaped antibacterial coating inner container (3). A guide pipe assembly (1) is only communicated with the small circular cavity body (22). The antibacterial coating inner container (3) is manufactured by the following steps that raw materials are obtained by mixing clay powder and medical paraffin according to the mass ratio of 100:5-20; the raw materials are made into the required barrel shape through a die, pressureless sintering at 1600 DEG C to 1700 DEG C is conducted for 2 to 4 hours, and the inner container is obtained; the surface of the inner container is loaded with an antibacterial coating.

The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for relieving physical fatigue and / or improving anoxia endurance, and a preparing method thereof. The traditional Chinese medicine composition for relieving physical fatigue and / or improving anoxia endurance is prepared from fresh ginger or extract thereof, herba rhodiolae or extract thereof and radix astragali or extract thereof based on the mass ratio of (1.5-4.5):(0.5-2.5):1. The traditional Chinese medicine composition has the healthcare functions of relieving physical fatigue, improving anoxia endurance and relieving chronic fatigue syndrome, and is reasonable in composition, remarkable in effect and free of genotoxicity.

The invention discloses an epidural-subcutaneous buried type analgesia pump with an anti-infection function. The epidural-subcutaneous buried type analgesia pump comprises a base (2). The base (2) is internally provided with a cavity. The cavity is composed of a large circular cavity body (21) and a small circular cavity body (22). The large circular cavity body (21) is located over the small circular cavity body (22). The lower end of a silica gel cover assembly (4) is connected with the large circular cavity body (21) in a seamless mode. The small circular cavity body (22) is internally provided with a barrel-shaped antibacterial coating inner container (3). A guide pipe assembly (1) is only communicated with the small circular cavity body (22). The antibacterial coating inner container (3) is manufactured by the following steps that raw materials are obtained by mixing clay powder and medical paraffin according to the mass ratio of 100:5-20; the raw materials are made into the required barrel shape through a die, pressureless sintering at 1600 DEG C to 1700 DEG C is conducted for 2 to 4 hours, and the inner container is obtained; the surface of the inner container is loaded with an antibacterial coating.

The invention discloses a purification method for reducing the protein content in sodium hyaluronate and its derivatives. The specific preparation process includes the following process steps: adding a specific type of protein complexing agent to the crude product solution of sodium hyaluronate and its derivatives, filtering The insoluble matter is removed, and pure sodium hyaluronate and its derivatives are obtained by alcohol precipitation. The present invention has a good effect on removing the protein in sodium hyaluronate and its derivative products through the function of protein complexing agent, and can reduce the protein content in sodium hyaluronate and its derivative products to below 0.015%, thus significantly It reduces the risk of allergic reactions caused by heterologous proteins to sodium hyaluronate and its derivative preparations, and has extremely high clinical application value; the method of the invention has simple process, low cost, easy operation, good economy, and is more suitable for industrialization Production; the sodium hyaluronate and its derivatives obtained in the present invention have high purity, good safety, less allergic reactions, and bring maximum benefits to patients.

The invention relates to a health food with auxiliary blood sugar and blood lipid lowering functions. The health food is characterized in that: each 1000 granules of capsules comprise 90-110g of purified konjak powder, 72-88g of extracts from acanthopanax, 54-66g of extracts from gynostemma pentaphylla, and 54-66g of extracts from green tea. The weight of contents in each granule of the capsule is 0.3g, and each 100g of the contents comprises 33.67-40.33g of glucomannan, 10.01-11.99g of tea polyphenol, and 3.01-3.59g of total saponins. The health food which is an oral capsule preparation and has the advantages of accurate efficacy, rapid action, safety and reliability, and small taking dosage is convenient for carrying and long-term taking; and the health food which simultaneously has dual auxiliary blood sugar and blood lipid lowering functions is helpful for rehabilitation of patients who only have hyperglycemia or hyperlipidemia, or simultaneously have hyperglycemia and hyperlipidemia, and also allows concurrent cardiovascular and cerebrovascular diseases and the like of diabetes and hyperlipidemia to be prevented. The health food of the invention is different from simple blood sugar and blood lipid products in the recent market.

The invention discloses an absorbable suture line. The absorbable suture line comprises a suture line body, wherein one end of the suture line body is connected with a needle, and a plurality of firstturnedodge structures and second turnedodge structures are alternately arranged on the side wall of the suture line body in the length direction of the suture line body; the absorbable suture line further comprises a pressing piece which is arranged on the suture line body in a penetrating mode and can be limited by the first turnedodge structures or the second turnedodge structures in a turnedodge state; and the turnedodge directions of the first turnedodge structures and the second turnedodge structures are opposite. According to the absorbable suture line, the suture line body can be effectively prevented from sliding relative to threading openings in the two sides of a wound, the pain feeling is reduced, the healing speed is increased, and the surface is flat after the wound is healed.

The invention discloses a medical oviduct stent device, which comprises a stent and an accessory, wherein the accessory comprises a guide tube and a guide wire; the tail end of the guide tube is provided with a stent prepared from chitosan and glycerol. A preparation method of the stent comprises the following steps of preparing 20 weight percent of chitosan acetic acid solution by an acetic acidsolution with the concentration being 10 to 30 weight percent; after the glycerol adding, performing mixing and filtering; performing still standing for 24 hours for defoaming; injecting the materialsinto a mod; putting the materials into a baking oven being 40 to 70 DEG C; performing drying, to obtain the stent. The guide tube has the length being 40 to 45 cm, the outer diameter being 1.5 to 3 mm, and the inner diameter being about 0.5 to 2 mm; the tail end 1 to 3 cm is in a cone shape; the guide wire has the length of 45 to 50 cm, and the diameter is 0.6 to 0.8 mm. By using the technical scheme provided by the invention, the preparation process is simple; the forms are various; convenience and practicability are realized; the stent has the characteristics that good biocompatibility andabsorbable degradation performance are realized; the device is favorable for wound surface restoration; the operation is simple and convenient, and the like. The oviduct recurrent obstruction is avoided; the postoperative intrauterine pregnancy rate is improved.

The invention provides a biodegradable material for preventing postoperative adhesion. A method for preparing the biodegradable material comprises the steps of adding a cross-linker into a 0.5-2.5% sodium hyaluronate solution, carrying out cross-linking reaction at the temperature of 0-80 DEG C, dialyzing a mixed solution in water after the reaction is ended, and drying the dialyzed solution, thereby obtaining the biodegradable material. The degradable biological material prepared by the method has good physical and chemical properties and biocompatibility, and can be used for effectively preventing the occurrence of postoperative adhesion.

The invention discloses a preparation method of high-purity sugammadex sodium, which is prepared by using phosphoinositol esters and derivatives thereof. The specific process is as follows: adding a specific type of protective agent to the crude product of sugammadex sodium; Under protection, the pure product of sugammadex sodium was obtained by recrystallization. Wherein, the protective agent is selected from inositol phosphate and derivatives thereof, such as inositol hexaphosphate and its salt or ester; partial degradation products of inositol hexaphosphate such as inositol pentaphosphate and inositol tetraphosphate , inositol triphosphate, inositol diphosphate, inositol monophosphate and one or more of the aforementioned substances and their salts or esters, or a mixture of two or more in any proportion. The method is easy to operate, high in product purity, good in safety, less in allergic reactions, good in economy, and more suitable for industrialized production.