Non-operative adhesive agent

A sticking and surgical technology, which is applied in the field of medical materials, can solve the problems of too late for doctors to operate, the polymer is hard and brittle, and does not develop, and achieves the effects of good physiological environment compatibility, low material cost, and small side effects

Inactive Publication Date: 2010-10-06
北京百利康生化有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the limited technical level at that time, the actual operation was inconvenient, clinically proved that the doctor was too late to operate, the polymer was hard and brittle, the monomer viscosity was small, easy to flow, and no development, etc., and it was not widely used.
[0004] In the mid-to-late 1990s, my country carried out research on adipine sterilization suppositories. Although this suppository is simple to administer, it lacks a standardized method of use. The specific operation is arbitrary, causing a large number of side effects, and serious complications. ectopic pregnancy occurred after the operation, so the application development was stopped because the potential long-term risk of the drug was not effectively evaluated

Method used

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  • Non-operative adhesive agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] ①Choose 50 grams of chitosan, 12 grams of hyaluronic acid, and 12 grams of gelatin, react at 50-220 ° C for 4-7 hours, freeze-dry and then aseptically package, which is the finished rod;

[0024] ②Choose 58 grams of chitosan, 9 grams of glycerin, and 12 grams of polylactic acid, and react for 1.5 to 3 hours at 50-180 ° C to obtain an absorbable medical film;

[0025] ③ Inject 5-15 ul of α-cyanopropene n-octyl ester into the chitosan membrane material, and package the membrane material and the rod together to obtain the plugging agent.

Embodiment 2

[0027] ①Choose 45 grams of chitosan, 5 grams of hyaluronic acid, 10 grams of polylactic acid, and 12 grams of gelatin, react at 50-220 °C for 5-7.5 hours, freeze-dry and aseptically package, that is, the finished rod;

[0028] ②Choose 55 grams of chitosan, 10 grams of hyaluronic acid, 6 grams of glycerin, and 8 grams of polylactic acid, and react for 2 to 4 hours at 50-180 ° C to obtain an absorbable medical film;

[0029] ③ Inject 5-25 ul of α-cyanopropene n-octyl ester into the chitosan membrane material, and package the membrane material and the rod together to obtain the plugging agent.

Embodiment 3

[0030] Embodiment 3: the pharmacological effect of medical new non-surgical sticky plugging agent

[0031] ① Model making: 20 clean-grade big-eared rabbits, all female, with a body weight of 2.5-3kg. In order to eliminate the influence of individual differences in rabbits on the therapeutic effect, the left oviduct of each rabbit was designed as the oviduct of the experimental group, The right fallopian tube was designed as the control fallopian tube. The animals were fixed in a supine position, and all animals were anesthetized by ear vein injection of 1% thiopental sodium (6 mg / kg body weight), and a medical plugging agent was placed in the left fallopian tube. Routine feeding after operation. After 2 weeks, 10 rabbits were randomly selected and classified into group A. They were killed by air embolism, laparotomy was performed, the uterus and bilateral fallopian tubes were dissected, and melanolone was performed at the same time, and melanin solution was injected into the ...

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Abstract

The invention discloses a non-operative adhesive agent. A blocking material of the adhesive agent adopts a chitosan medical rod-shaped material and a wrapping material of the adhesive agent adopts a chitosan medical film material to wrap an alpha-cyanoacrylate adhesive; the chitosan medical rod-shaped material is a copolymer of the following raw materials in part by weight: 10 to 75 parts of chitosan, 1 to 45 parts of hyaluronic acid, 0 to 45 parts of polylactic acid and 0 to 20 parts of gelatin; and the chitosan medical film material is a copolymer of the following raw materials in part by weight: 10 to 50 parts of chitosan, 1 to 60 parts of hyaluronic acid, 0 to 35 parts of glycerol and 0 to 45 parts of polylactic acid. The invention also discloses a preparation method of the non-operative adhesive agent. The adhesive agent is a purely natural extract, has low cost and rich source and cannot generate any toxic or side effects when in use. The application of the adhesive to implementation of contraception has the advantages of no operation, little pain and small side effect and cannot influence work and life.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular, the invention is a non-surgical plugging agent. Background technique [0002] At present, surgical sterilization is the main method of female sterilization. However, in terms of acceptability, when choosing between non-surgical ligation and surgical ligation, most women are willing to accept non-surgical ligation because it is less painful than surgical sterilization. Short rest time and no surgical operation are required, which means that the risk of infection, trauma and death is less; secondly, the operation process of non-surgical methods is relatively simple, and after training, medical staff at all levels can operate, so there is an urgent need A safe and highly effective non-surgical sterilization product. [0003] As early as the 1970s, my country carried out scientific and technological research on male and female sterilization adhesives. The medical α-cyanoprop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/14A61L31/04
Inventor 王国强施波
Owner 北京百利康生化有限公司
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